ID D3YZ94_MOUSE Unreviewed; 207 AA. AC D3YZ94; DT 20-APR-2010, integrated into UniProtKB/TrEMBL. DT 20-APR-2010, sequence version 1. DT 12-OCT-2022, entry version 87. DE SubName: Full=Homeobox protein OTX2 {ECO:0000313|Ensembl:ENSMUSP00000123454}; DE Flags: Fragment; GN Name=Otx2 {ECO:0000313|Ensembl:ENSMUSP00000123454, GN ECO:0000313|MGI:MGI:97451}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000123454, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000123454, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000123454, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000123454} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000123454}; RG Ensembl; RL Submitted (MAY-2011) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}. CC -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily. CC {ECO:0000256|ARBA:ARBA00006503}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR SMR; D3YZ94; -. DR PeptideAtlas; D3YZ94; -. DR ProteomicsDB; 365505; -. DR Antibodypedia; 49; 437 antibodies from 37 providers. DR Ensembl; ENSMUST00000152018.8; ENSMUSP00000123454.2; ENSMUSG00000021848.17. DR MGI; MGI:97451; Otx2. DR VEuPathDB; HostDB:ENSMUSG00000021848; -. DR GeneTree; ENSGT00940000155014; -. DR HOGENOM; CLU_064370_2_1_1; -. DR OMA; KSPHYAM; -. DR ChiTaRS; Otx2; mouse. DR Proteomes; UP000000589; Chromosome 14. DR Bgee; ENSMUSG00000021848; Expressed in pineal body and 139 other tissues. DR ExpressionAtlas; D3YZ94; baseline and differential. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro. DR CDD; cd00086; homeodomain; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR003022; Otx2_TF. DR InterPro; IPR003025; Otx_TF. DR InterPro; IPR013851; Otx_TF_C. DR Pfam; PF00046; Homeodomain; 1. DR Pfam; PF03529; TF_Otx; 1. DR PRINTS; PR01257; OTX2HOMEOBOX. DR PRINTS; PR01255; OTXHOMEOBOX. DR SMART; SM00389; HOX; 1. DR SUPFAM; SSF46689; SSF46689; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. PE 1: Evidence at protein level; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE- KW ProRule:PRU00108}; KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE- KW ProRule:PRU00108}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE- KW ProRule:PRU00108}; KW Proteomics identification {ECO:0007829|MaxQB:D3YZ94, KW ECO:0007829|PeptideAtlas:D3YZ94}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. FT DOMAIN 36..96 FT /note="Homeobox" FT /evidence="ECO:0000259|PROSITE:PS50071" FT DNA_BIND 38..97 FT /note="Homeobox" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108" FT REGION 93..143 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 93..109 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 120..143 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 207 FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000123454" SQ SEQUENCE 207 AA; 22742 MW; 937C55D8AD682141 CRC64; MMSYLKQPPY AVNGLSLTTS GMDLLHPSVG YPATPRKQRR ERTTFTRAQL DVLEALFAKT RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQQQ QNGGQNKVRP AKKKSSPARE VSSESGTSGQ FSPPSSTSVP TIASSSAPVS IWSPASISPL SDPLSTSSSC MQRSYPMTYT QASGYSQGYA GSTSYFGGMD CGSYLTP //