ID D3YZ94_MOUSE Unreviewed; 207 AA. AC D3YZ94; DT 20-APR-2010, integrated into UniProtKB/TrEMBL. DT 20-APR-2010, sequence version 1. DT 22-JUL-2015, entry version 43. DE SubName: Full=Homeobox protein OTX2 {ECO:0000313|Ensembl:ENSMUSP00000123454}; DE Flags: Fragment; GN Name=Otx2 {ECO:0000313|Ensembl:ENSMUSP00000123454, GN ECO:0000313|MGI:MGI:97451}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000123454, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000123454, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000123454, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000123454} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000123454}; RG Ensembl; RL Submitted (MAY-2011) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000682}. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000123454}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC166574; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; D3YZ94; -. DR SMR; D3YZ94; 39-106. DR STRING; 10090.ENSMUSP00000113690; -. DR Ensembl; ENSMUST00000152018; ENSMUSP00000123454; ENSMUSG00000021848. DR MGI; MGI:97451; Otx2. DR GeneTree; ENSGT00760000118908; -. DR HOGENOM; HOG000082677; -. DR ChiTaRS; Otx2; mouse. DR NextBio; 35549737; -. DR Proteomes; UP000000589; Chromosome 14. DR Bgee; D3YZ94; -. DR ExpressionAtlas; D3YZ94; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IDA:MGI. DR GO; GO:0030426; C:growth cone; ISO:MGI. DR GO; GO:0005634; C:nucleus; IDA:MGI. DR GO; GO:0043234; C:protein complex; ISO:MGI. DR GO; GO:0046982; F:protein heterodimerization activity; IPI:MGI. DR GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; ISO:MGI. DR GO; GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; ISO:MGI. DR GO; GO:0048856; P:anatomical structure development; IGI:MGI. DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI. DR GO; GO:0007411; P:axon guidance; ISO:MGI. DR GO; GO:0030154; P:cell differentiation; IMP:MGI. DR GO; GO:0045165; P:cell fate commitment; IMP:MGI. DR GO; GO:0001708; P:cell fate specification; IMP:MGI. DR GO; GO:0007417; P:central nervous system development; IMP:MGI. DR GO; GO:0048852; P:diencephalon morphogenesis; IGI:MGI. DR GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:MGI. DR GO; GO:0007492; P:endoderm development; IGI:MGI. DR GO; GO:0042706; P:eye photoreceptor cell fate commitment; IMP:MGI. DR GO; GO:0030900; P:forebrain development; IMP:MGI. DR GO; GO:0042472; P:inner ear morphogenesis; IGI:MGI. DR GO; GO:0022037; P:metencephalon development; IGI:MGI. DR GO; GO:0030901; P:midbrain development; IMP:MGI. DR GO; GO:0030182; P:neuron differentiation; IMP:MGI. DR GO; GO:0048663; P:neuron fate commitment; IMP:MGI. DR GO; GO:0048664; P:neuron fate determination; IMP:MGI. DR GO; GO:0009887; P:organ morphogenesis; IMP:MGI. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI. DR GO; GO:0090009; P:primitive streak formation; IMP:MGI. DR GO; GO:0006461; P:protein complex assembly; ISO:MGI. DR GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:MGI. DR GO; GO:0032525; P:somite rostral/caudal axis specification; IMP:MGI. DR GO; GO:0006366; P:transcription from RNA polymerase II promoter; ISO:GOC. DR Gene3D; 1.10.10.60; -; 1. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR009057; Homeodomain-like. DR InterPro; IPR003022; Otx2_TF. DR InterPro; IPR003025; Otx_TF. DR InterPro; IPR013851; Otx_TF_C. DR PANTHER; PTHR24329:SF131; PTHR24329:SF131; 1. DR Pfam; PF00046; Homeobox; 1. DR Pfam; PF03529; TF_Otx; 1. DR PRINTS; PR01257; OTX2HOMEOBOX. DR PRINTS; PR01255; OTXHOMEOBOX. DR SMART; SM00389; HOX; 1. DR SUPFAM; SSF46689; SSF46689; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW DNA-binding {ECO:0000256|RuleBase:RU000682}; KW Homeobox {ECO:0000256|RuleBase:RU000682}; KW Nucleus {ECO:0000256|RuleBase:RU000682}; KW Proteomics identification {ECO:0000213|PeptideAtlas:D3YZ94}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. FT NON_TER 207 207 {ECO:0000313|Ensembl:ENSMUSP00000123454}. SQ SEQUENCE 207 AA; 22742 MW; 937C55D8AD682141 CRC64; MMSYLKQPPY AVNGLSLTTS GMDLLHPSVG YPATPRKQRR ERTTFTRAQL DVLEALFAKT RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQQQ QNGGQNKVRP AKKKSSPARE VSSESGTSGQ FSPPSSTSVP TIASSSAPVS IWSPASISPL SDPLSTSSSC MQRSYPMTYT QASGYSQGYA GSTSYFGGMD CGSYLTP //