ID D3YTP0_MOUSE Unreviewed; 418 AA. AC D3YTP0; DT 20-APR-2010, integrated into UniProtKB/TrEMBL. DT 05-OCT-2016, sequence version 8. DT 12-OCT-2022, entry version 79. DE SubName: Full=Metalloreductase STEAP3 {ECO:0000313|Ensembl:ENSMUSP00000121046}; DE Flags: Fragment; GN Name=Steap3 {ECO:0000313|Ensembl:ENSMUSP00000121046, GN ECO:0000313|MGI:MGI:1915678}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000121046, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0007829|PubMed:17242355} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=17242355; DOI=10.1073/pnas.0609836104; RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; RT "Large-scale phosphorylation analysis of mouse liver."; RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). RN [2] {ECO:0007829|PubMed:19144319} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006; RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M., RA Thibault P.; RT "The phagosomal proteome in interferon-gamma-activated macrophages."; RL Immunity 30:143-154(2009). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000121046, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000121046, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [4] {ECO:0007829|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [5] {ECO:0000313|Ensembl:ENSMUSP00000121046} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000121046}; RG Ensembl; RL Submitted (MAY-2011) to UniProtKB. CC -!- COFACTOR: CC Name=FAD; Xref=ChEBI:CHEBI:57692; CC Evidence={ECO:0000256|ARBA:ARBA00001974}; CC -!- COFACTOR: CC Name=heme; Xref=ChEBI:CHEBI:30413; CC Evidence={ECO:0000256|ARBA:ARBA00001971}; CC -!- SUBCELLULAR LOCATION: Endosome membrane CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004337}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the STEAP family. CC {ECO:0000256|ARBA:ARBA00007729}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR SMR; D3YTP0; -. DR jPOST; D3YTP0; -. DR PeptideAtlas; D3YTP0; -. DR PRIDE; D3YTP0; -. DR ProteomicsDB; 314078; -. DR Antibodypedia; 18292; 294 antibodies from 33 providers. DR Ensembl; ENSMUST00000140490.8; ENSMUSP00000121046.2; ENSMUSG00000026389.17. DR MGI; MGI:1915678; Steap3. DR VEuPathDB; HostDB:ENSMUSG00000026389; -. DR GeneTree; ENSGT00390000008042; -. DR ChiTaRS; Steap3; mouse. DR Proteomes; UP000000589; Chromosome 1. DR Bgee; ENSMUSG00000026389; Expressed in lumbar dorsal root ganglion and 167 other tissues. DR ExpressionAtlas; D3YTP0; baseline and differential. DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW. DR InterPro; IPR013130; Fe3_Rdtase_TM_dom. DR InterPro; IPR036291; NAD(P)-bd_dom_sf. DR InterPro; IPR028939; P5C_Rdtase_cat_N. DR Pfam; PF03807; F420_oxidored; 1. DR Pfam; PF01794; Ferric_reduct; 1. DR SUPFAM; SSF51735; SSF51735; 1. PE 1: Evidence at protein level; KW Copper {ECO:0000256|ARBA:ARBA00023008}; KW Endosome {ECO:0000256|ARBA:ARBA00022753}; KW Ion transport {ECO:0000256|ARBA:ARBA00022496}; KW Iron {ECO:0000256|ARBA:ARBA00022496}; KW Iron transport {ECO:0000256|ARBA:ARBA00022496}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0007829|EPD:D3YTP0, KW ECO:0007829|MaxQB:D3YTP0}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022496}. FT TRANSMEM 214..232 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 252..280 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 305..326 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 359..379 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 391..412 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 30..117 FT /note="F420_oxidored" FT /evidence="ECO:0000259|Pfam:PF03807" FT DOMAIN 260..404 FT /note="Ferric oxidoreductase" FT /evidence="ECO:0000259|Pfam:PF01794" FT NON_TER 418 FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000121046" SQ SEQUENCE 418 AA; 46879 MW; B2905771733A9A96 CRC64; MSGEMDKPLI SRRLVDSDGS LAEVPKEAPK VGILGSGDFA RSLATRLVGS GFSVVVGSRN PKRTAGLFPS LAQVTFQEEA VSSPEVIFVA VFREHYSSLC SLADQLAGKI LVDVSNPTEK EHLQHRQSNA EYLASLFPAC TVVKAFNVIS AWALQAGPRD GNRQVLICSD QPEAKRTISE MARAMGFTPL DMGSLASARE VEAIPLRLLP SWKVPTLLAL GLFVCFYTYN FIRDVLQPYI RKDENKFYKM PLSVVNTTLP CVAYVLLSLV YLPGVLAAAL QLRRGTKYQR FPDWLDHWLQ HRKQIGLLSF FFAMLHALYS FCLPLRRSHR YDLVNLAVKQ VLANKSRLWA EEEVWRMEIY LSLGVLALGM LSLLAVTSLP SIANSLNWKE FSFVQQVFYL LRILSSPLYS FYTNLSKL //