ID D3Y2F8_MOUSE Unreviewed; 644 AA. AC D3Y2F8; DT 20-APR-2010, integrated into UniProtKB/TrEMBL. DT 20-APR-2010, sequence version 1. DT 27-MAR-2024, entry version 62. DE RecName: Full=Metal transporter {ECO:0000256|RuleBase:RU369091}; GN Name=Cnnm4 {ECO:0000313|MGI:MGI:2151060}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:ADC80900.1}; RN [1] {ECO:0000313|EMBL:ADC80900.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Swiss Albino {ECO:0000313|EMBL:ADC80900.1}; RC TISSUE=Testis {ECO:0000313|EMBL:ADC80900.1}; RA Prasad V.S., Kumar P.G.; RL Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Metal transporter. {ECO:0000256|RuleBase:RU369091}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU369091}; CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU369091}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the ACDP family. {ECO:0000256|ARBA:ARBA00010484, CC ECO:0000256|RuleBase:RU369091}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GU390541; ADC80900.1; -; mRNA. DR AlphaFoldDB; D3Y2F8; -. DR PeptideAtlas; D3Y2F8; -. DR AGR; MGI:2151060; -. DR MGI; MGI:2151060; Cnnm4. DR ChiTaRS; Cnnm4; mouse. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule. DR GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro. DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1. DR Gene3D; 3.10.580.10; CBS-domain; 1. DR Gene3D; 2.60.120.10; Jelly Rolls; 1. DR InterPro; IPR045095; ACDP. DR InterPro; IPR000644; CBS_dom. DR InterPro; IPR046342; CBS_dom_sf. DR InterPro; IPR018490; cNMP-bd_dom_sf. DR InterPro; IPR002550; CNNM. DR InterPro; IPR044751; Ion_transp-like_CBS. DR InterPro; IPR014710; RmlC-like_jellyroll. DR PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1. DR PANTHER; PTHR12064:SF26; METAL TRANSPORTER CNNM4; 1. DR Pfam; PF00571; CBS; 1. DR Pfam; PF01595; CNNM; 1. DR SUPFAM; SSF51206; cAMP-binding domain-like; 1. DR SUPFAM; SSF54631; CBS-domain pair; 1. DR PROSITE; PS51371; CBS; 1. DR PROSITE; PS51846; CNNM; 1. PE 2: Evidence at transcript level; KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE- KW ProRule:PRU01193}; Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE- KW ProRule:PRU01193}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE- KW ProRule:PRU01193}. FT TRANSMEM 52..76 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU369091" FT TRANSMEM 110..131 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU369091" FT TRANSMEM 137..156 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU369091" FT TRANSMEM 168..188 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU369091" FT DOMAIN 48..228 FT /note="CNNM transmembrane" FT /evidence="ECO:0000259|PROSITE:PS51846" FT DOMAIN 315..381 FT /note="CBS" FT /evidence="ECO:0000259|PROSITE:PS51371" SQ SEQUENCE 644 AA; 73252 MW; 8B8F9E6431CA979B CRC64; MLVVITKFLR RSENTKLYAL CTRPRADGPW TRWTDKDSLL FMVEEHGRFL PLWLHILLVM VLLVLSGIFS GLNLGLMALD PMELRIVQSC GTEKERKYAR KIEPIRRKGN YLLCSLLLGN VLVNTSLTIL LDNLIGSGIM AVASSTIGIV IFGEILPQAL CSRHGLAVGA NTIVLTKVFM LLTFPLSFPI SKLLDFVLGQ EIRTVYNREK LMEMLKVTEP YNDLVKEELN MIQGALELRT KTVEDIMTQL HDCFMIRSDA ILDFNTMSEI MESGYTRIPV FEDEQSNIVD ILYVKDLAFV DPDDCTPLKT ITRFYNHPVH FVFHDTKLDA MLEEFKKGKS HLAIVQKVNN EGEGDPFYEV LGLVTLEDVI EEIIKSEILD ESDMYIDNRT LKRVSVKNKR DFSAFKDTDN ELKVKISPQL LLAAHRFLAT EVPQFSPSLM SEKILLRLLK YPDVIQELRF NEHNRYCVRH YLYTRNKPAD CFVLILQGKV EVEAGKENMK FETGAFSYYG TMALSVAPPD RSPALPTPLS RSASLSYPDR NTDLTSTSLA GSNQFGRCIL GQYVSDFSVR ALTDLQYIKI TRQQYQNGLM ASRIDNSPQP TFDGCATCSE NFMERPELPP VDETTTLLNE RNSLLHRASE EETI //