ID D3UAS6_OVIVI Unreviewed; 56 AA. AC D3UAS6; DT 20-APR-2010, integrated into UniProtKB/TrEMBL. DT 20-APR-2010, sequence version 1. DT 29-MAY-2024, entry version 43. DE RecName: Full=Interleukin-4 {ECO:0000256|ARBA:ARBA00019467}; DE AltName: Full=B-cell stimulatory factor 1 {ECO:0000256|ARBA:ARBA00031287}; DE AltName: Full=Lymphocyte stimulatory factor 1 {ECO:0000256|ARBA:ARBA00030247}; DE Flags: Fragment; GN Name=IL4 {ECO:0000313|EMBL:ADD51451.1}; OS Ovis vignei (Urial sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Caprinae; Ovis. OX NCBI_TaxID=59896 {ECO:0000313|EMBL:ADD51451.1}; RN [1] {ECO:0000313|EMBL:ADD51451.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=OVNo2 {ECO:0000313|EMBL:ADD51451.1}, and OVNo6 RC {ECO:0000313|EMBL:ADD51452.1}; RX PubMed=19897045; DOI=10.1016/j.ympev.2009.10.037; RA Rezaei H.R., Naderi S., Chintauan-Marquier I.C., Taberlet P., Virk A.T., RA Naghash H.R., Rioux D., Kaboli M., Pompanon F.; RT "Evolution and taxonomy of the wild species of the genus Ovis (Mammalia, RT Artiodactyla, Bovidae)."; RL Mol. Phylogenet. Evol. 0:0-0(2009). CC -!- FUNCTION: Participates in at least several B-cell activation processes CC as well as of other cell types. It is a costimulator of DNA-synthesis. CC It induces the expression of class II MHC molecules on resting B-cells. CC It enhances both secretion and cell surface expression of IgE and IgG1. CC It also regulates the expression of the low affinity Fc receptor for CC IgE (CD23) on both lymphocytes and monocytes. Positively regulates CC IL31RA expression in macrophages. Stimulates autophagy in dendritic CC cells by interfering with mTORC1 signaling and through the induction of CC RUFY4. {ECO:0000256|ARBA:ARBA00003994}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FJ936373; ADD51451.1; -; Genomic_DNA. DR EMBL; FJ936374; ADD51452.1; -; Genomic_DNA. DR AlphaFoldDB; D3UAS6; -. DR SMR; D3UAS6; -. DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter. DR GO; GO:0005125; F:cytokine activity; IEA:TreeGrafter. DR GO; GO:0008083; F:growth factor activity; IEA:InterPro. DR GO; GO:0005136; F:interleukin-4 receptor binding; IEA:InterPro. DR GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW. DR GO; GO:0031296; P:B cell costimulation; IEA:TreeGrafter. DR GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:TreeGrafter. DR GO; GO:0002227; P:innate immune response in mucosa; IEA:TreeGrafter. DR GO; GO:0001774; P:microglial cell activation; IEA:TreeGrafter. DR GO; GO:0043011; P:myeloid dendritic cell differentiation; IEA:TreeGrafter. DR GO; GO:0002674; P:negative regulation of acute inflammatory response; IEA:TreeGrafter. DR GO; GO:0002677; P:negative regulation of chronic inflammatory response; IEA:TreeGrafter. DR GO; GO:1903660; P:negative regulation of complement-dependent cytotoxicity; IEA:TreeGrafter. DR GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; IEA:TreeGrafter. DR GO; GO:0010633; P:negative regulation of epithelial cell migration; IEA:TreeGrafter. DR GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IEA:TreeGrafter. DR GO; GO:0043031; P:negative regulation of macrophage activation; IEA:TreeGrafter. DR GO; GO:2000320; P:negative regulation of T-helper 17 cell differentiation; IEA:TreeGrafter. DR GO; GO:1900223; P:positive regulation of amyloid-beta clearance; IEA:TreeGrafter. DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:TreeGrafter. DR GO; GO:0002230; P:positive regulation of defense response to virus by host; IEA:TreeGrafter. DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:TreeGrafter. DR GO; GO:2000424; P:positive regulation of eosinophil chemotaxis; IEA:TreeGrafter. DR GO; GO:0032733; P:positive regulation of interleukin-10 production; IEA:TreeGrafter. DR GO; GO:0032736; P:positive regulation of interleukin-13 production; IEA:TreeGrafter. DR GO; GO:0048295; P:positive regulation of isotype switching to IgE isotypes; IEA:TreeGrafter. DR GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; IEA:TreeGrafter. DR GO; GO:0016239; P:positive regulation of macroautophagy; IEA:TreeGrafter. DR GO; GO:0043306; P:positive regulation of mast cell degranulation; IEA:TreeGrafter. DR GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; IEA:TreeGrafter. DR GO; GO:0071677; P:positive regulation of mononuclear cell migration; IEA:TreeGrafter. DR GO; GO:1901741; P:positive regulation of myoblast fusion; IEA:TreeGrafter. DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IEA:TreeGrafter. DR GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:TreeGrafter. DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:TreeGrafter. DR GO; GO:0045064; P:T-helper 2 cell differentiation; IEA:TreeGrafter. DR Gene3D; 1.20.1250.10; -; 1. DR InterPro; IPR009079; 4_helix_cytokine-like_core. DR InterPro; IPR002354; IL-4. DR InterPro; IPR001325; IL-4/IL-13. DR PANTHER; PTHR47401; INTERLEUKIN-4; 1. DR PANTHER; PTHR47401:SF1; INTERLEUKIN-4; 1. DR Pfam; PF00727; IL4; 1. DR SMART; SM00190; IL4_13; 1. DR SUPFAM; SSF47266; 4-helical cytokines; 1. PE 4: Predicted; KW B-cell activation {ECO:0000256|ARBA:ARBA00022936}; KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..27 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 28..56 FT /note="Interleukin-4" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5007651149" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:ADD51451.1" FT NON_TER 56 FT /evidence="ECO:0000313|EMBL:ADD51451.1" SQ SEQUENCE 56 AA; 6255 MW; BF1E9DCCDECBB4CC CRC64; YILMGLTSQL IPALVCLLVC TSHFVHGHKC DITLEEIIKT LNILTSRKNS CMELPV //