ID D3UAS6_OVIVI Unreviewed; 56 AA. AC D3UAS6; DT 20-APR-2010, integrated into UniProtKB/TrEMBL. DT 20-APR-2010, sequence version 1. DT 12-OCT-2022, entry version 38. DE RecName: Full=Interleukin-4 {ECO:0000256|ARBA:ARBA00019467}; DE AltName: Full=B-cell stimulatory factor 1 {ECO:0000256|ARBA:ARBA00031287}; DE AltName: Full=Lymphocyte stimulatory factor 1 {ECO:0000256|ARBA:ARBA00030247}; DE Flags: Fragment; GN Name=IL4 {ECO:0000313|EMBL:ADD51451.1}; OS Ovis vignei (Urial sheep). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Caprinae; Ovis. OX NCBI_TaxID=59896 {ECO:0000313|EMBL:ADD51451.1}; RN [1] {ECO:0000313|EMBL:ADD51451.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=OVNo2 {ECO:0000313|EMBL:ADD51451.1}, and OVNo6 RC {ECO:0000313|EMBL:ADD51452.1}; RX PubMed=19897045; DOI=10.1016/j.ympev.2009.10.037; RA Rezaei H.R., Naderi S., Chintauan-Marquier I.C., Taberlet P., Virk A.T., RA Naghash H.R., Rioux D., Kaboli M., Pompanon F.; RT "Evolution and taxonomy of the wild species of the genus Ovis (Mammalia, RT Artiodactyla, Bovidae)."; RL Mol. Phylogenet. Evol. 0:0-0(2009). CC -!- FUNCTION: Participates in at least several B-cell activation processes CC as well as of other cell types. It is a costimulator of DNA-synthesis. CC It induces the expression of class II MHC molecules on resting B-cells. CC It enhances both secretion and cell surface expression of IgE and IgG1. CC It also regulates the expression of the low affinity Fc receptor for CC IgE (CD23) on both lymphocytes and monocytes. Positively regulates CC IL31RA expression in macrophages. Stimulates autophagy in dendritic CC cells by interfering with mTORC1 signaling and through the induction of CC RUFY4. {ECO:0000256|ARBA:ARBA00003994}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FJ936373; ADD51451.1; -; Genomic_DNA. DR EMBL; FJ936374; ADD51452.1; -; Genomic_DNA. DR SMR; D3UAS6; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0008083; F:growth factor activity; IEA:InterPro. DR GO; GO:0005136; F:interleukin-4 receptor binding; IEA:InterPro. DR GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 1.20.1250.10; -; 1. DR InterPro; IPR009079; 4_helix_cytokine-like_core. DR InterPro; IPR002354; IL-4. DR InterPro; IPR001325; IL-4/IL-13. DR PANTHER; PTHR47401; PTHR47401; 1. DR Pfam; PF00727; IL4; 1. DR SMART; SM00190; IL4_13; 1. DR SUPFAM; SSF47266; SSF47266; 1. PE 4: Predicted; KW B-cell activation {ECO:0000256|ARBA:ARBA00022936}; KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..27 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 28..56 FT /note="Interleukin-4" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5007651149" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:ADD51451.1" FT NON_TER 56 FT /evidence="ECO:0000313|EMBL:ADD51451.1" SQ SEQUENCE 56 AA; 6255 MW; BF1E9DCCDECBB4CC CRC64; YILMGLTSQL IPALVCLLVC TSHFVHGHKC DITLEEIIKT LNILTSRKNS CMELPV //