ID   D3UAS6_OVIVI            Unreviewed;        56 AA.
AC   D3UAS6;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   07-APR-2021, entry version 33.
DE   RecName: Full=B-cell stimulatory factor 1 {ECO:0000256|ARBA:ARBA00021910};
DE   AltName: Full=Interleukin-4 {ECO:0000256|ARBA:ARBA00019467};
DE   AltName: Full=Lymphocyte stimulatory factor 1 {ECO:0000256|ARBA:ARBA00019947};
DE   Flags: Fragment;
GN   Name=IL4 {ECO:0000313|EMBL:ADD51451.1};
OS   Ovis vignei (Urial sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=59896 {ECO:0000313|EMBL:ADD51451.1};
RN   [1] {ECO:0000313|EMBL:ADD51451.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=OVNo2 {ECO:0000313|EMBL:ADD51451.1}, and OVNo6
RC   {ECO:0000313|EMBL:ADD51452.1};
RX   PubMed=19897045; DOI=10.1016/j.ympev.2009.10.037;
RA   Rezaei H.R., Naderi S., Chintauan-Marquier I.C., Taberlet P., Virk A.T.,
RA   Naghash H.R., Rioux D., Kaboli M., Pompanon F.;
RT   "Evolution and taxonomy of the wild species of the genus Ovis (Mammalia,
RT   Artiodactyla, Bovidae).";
RL   Mol. Phylogenet. Evol. 0:0-0(2009).
CC   -!- FUNCTION: Participates in at least several B-cell activation processes
CC       as well as of other cell types. It is a costimulator of DNA-synthesis.
CC       It induces the expression of class II MHC molecules on resting B-cells.
CC       It enhances both secretion and cell surface expression of IgE and IgG1.
CC       It also regulates the expression of the low affinity Fc receptor for
CC       IgE (CD23) on both lymphocytes and monocytes. Positively regulates
CC       IL31RA expression in macrophages. Stimulates autophagy in dendritic
CC       cells by interfering with mTORC1 signaling and through the induction of
CC       RUFY4. {ECO:0000256|ARBA:ARBA00003994}.
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DR   EMBL; FJ936373; ADD51451.1; -; Genomic_DNA.
DR   EMBL; FJ936374; ADD51452.1; -; Genomic_DNA.
DR   SMR; D3UAS6; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR   GO; GO:0005136; F:interleukin-4 receptor binding; IEA:InterPro.
DR   GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR002354; IL-4.
DR   InterPro; IPR001325; IL-4/IL-13.
DR   PANTHER; PTHR47401; PTHR47401; 1.
DR   Pfam; PF00727; IL4; 1.
DR   SMART; SM00190; IL4_13; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   4: Predicted;
KW   B-cell activation {ECO:0000256|ARBA:ARBA00022936};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           28..56
FT                   /note="B-cell stimulatory factor 1"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5007651149"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ADD51451.1"
FT   NON_TER         56
FT                   /evidence="ECO:0000313|EMBL:ADD51451.1"
SQ   SEQUENCE   56 AA;  6255 MW;  BF1E9DCCDECBB4CC CRC64;
     YILMGLTSQL IPALVCLLVC TSHFVHGHKC DITLEEIIKT LNILTSRKNS CMELPV
//