ID D3JZW5_HUMAN Unreviewed; 143 AA. AC D3JZW5; DT 23-MAR-2010, integrated into UniProtKB/TrEMBL. DT 23-MAR-2010, sequence version 1. DT 02-DEC-2020, entry version 48. DE SubName: Full=E3 ubiquitin-protein ligase parkin {ECO:0000313|Ensembl:ENSP00000343589}; DE SubName: Full=Truncated parkin variant SV4,8DEL {ECO:0000313|EMBL:ADB91978.1}; DE SubName: Full=Truncated parkin variant SV4DEL {ECO:0000313|EMBL:ADB90269.1}; DE EC=6.3.2.19 {ECO:0000313|EMBL:ADB90269.1, ECO:0000313|EMBL:ADB91978.1}; GN Name=PRKN {ECO:0000313|Ensembl:ENSP00000343589}; GN Synonyms=PARK2 {ECO:0000313|EMBL:ADB90269.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ADB90269.1}; RN [1] {ECO:0000313|Ensembl:ENSP00000343589, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., RA Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I., RA Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|EMBL:ADB90269.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Retina {ECO:0000313|EMBL:ADB90269.1}; RA Campello L., Esteve-Rudd J., Cuenca N., Martin-Nieto J.; RT "Homo sapiens PARK2 SV4DEL transcript variant."; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:ADB91978.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Brain {ECO:0000313|EMBL:ADB91978.1}; RA Campello L., Esteve-Rudd J., Cuenca N., Martin-Nieto J.; RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Ensembl:ENSP00000343589} RP IDENTIFICATION. RG Ensembl; RL Submitted (AUG-2020) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL035697; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL078583; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL132982; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL138716; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL445215; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF458345; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF458347; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF495747; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; GU345838; ADB90269.1; -; mRNA. DR EMBL; GU361466; ADB91978.1; -; mRNA. DR Ensembl; ENST00000338468; ENSP00000343589; ENSG00000185345. DR HGNC; HGNC:8607; PRKN. DR ChiTaRS; PARK2; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW. DR InterPro; IPR015496; Ubiquilin. DR InterPro; IPR000626; Ubiquitin-like_dom. DR InterPro; IPR029071; Ubiquitin-like_domsf. DR InterPro; IPR019956; Ubiquitin_dom. DR PANTHER; PTHR10677; PTHR10677; 1. DR Pfam; PF00240; ubiquitin; 1. DR PRINTS; PR00348; UBIQUITIN. DR SMART; SM00213; UBQ; 1. DR SUPFAM; SSF54236; SSF54236; 1. DR PROSITE; PS50053; UBIQUITIN_2; 1. PE 2: Evidence at transcript level; KW Ligase {ECO:0000313|EMBL:ADB90269.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 1..72 FT /note="Ubiquitin-like" FT /evidence="ECO:0000259|PROSITE:PS50053" FT REGION 77..112 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 124..143 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 143 AA; 15521 MW; B97B8299DB799341 CRC64; MIVFVRFNSS HGFPVEVDSD TSIFQLKEVV AKRQGVPADQ LRVIFAGKEL RNDWTVQNCD LDQQSIVHIV QRPWRKGQEM NATGGDDPRN AAGGCEREPQ SLTRVDLSSS VLPGDSVGLA VILHTDSRKD SPPAGSPGSI LLG //