ID D3DYW9_9EURY Unreviewed; 349 AA. AC D3DYW9; DT 23-MAR-2010, integrated into UniProtKB/TrEMBL. DT 23-MAR-2010, sequence version 1. DT 20-APR-2010, entry version 2. DE RecName: Full=Aspartate-semialdehyde dehydrogenase; DE EC=1.2.1.11; GN Name=asd; ORFNames=mru_1669; OS Methanobrevibacter ruminantium M1. OC Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales; OC Methanobacteriaceae; Methanobrevibacter. OX NCBI_TaxID=634498; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=M1; RA Leahy S.C., Kelly W.J., Altermann E., Ronimus R.S., Yeoman C.J., RA Pacheco D.M., Li D., Kong Z., McTavish S., Sang C., Lambie S.C., RA Janssen P.H., Attwood G.T.; RT "The genome sequence of the rumen methanogen Methanobrevibacter RT ruminantium M1."; RL PLoS ONE 5:e8926-e8926(2010). CC -!- CATALYTIC ACTIVITY: L-aspartate 4-semialdehyde + phosphate + CC NADP(+) = L-4-aspartyl phosphate + NADPH. CC -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP CC pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4. CC -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de CC novo pathway; L-homoserine from L-aspartate: step 2/3. CC -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L- CC threonine from L-aspartate: step 2/5. CC -!- SIMILARITY: Belongs to the aspartate-semialdehyde dehydrogenase CC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP001719; ADC47519.1; -; Genomic_DNA. DR RefSeq; YP_003424411.1; -. DR InterPro; IPR000319; Asp-semialdehyde_DH_CS. DR InterPro; IPR005676; Asp_semi-ald_DH_pep-lack. DR InterPro; IPR012080; Asp_semialdehyde_DH. DR InterPro; IPR016040; NAD(P)-bd_dom. DR InterPro; IPR000534; Semialdehyde_DH_NAD-bd. DR InterPro; IPR012280; Semialdhyde_DH_dimer_dom. DR Pfam; PF01118; Semialdhyde_dh; 1. DR Pfam; PF02774; Semialdhyde_dhC; 1. DR PIRSF; PIRSF000148; ASA_dh; 1. DR SMART; SM00859; Semialdhyde_dh; 1. DR SUPFAM; SSF51735; NAD(P)-bd; 1. DR TIGRFAMs; TIGR00978; asd_EA; 1. DR PROSITE; PS01103; ASD; 1. PE 3: Inferred from homology; KW Amino-acid biosynthesis; NADP; Oxidoreductase. SQ SEQUENCE 349 AA; 38336 MW; 30B76E17D60ABB69 CRC64; MVKVGVLGAT GMVGQRFIQL LADHPDFEIA ALAASSRSAG KKYEDATTWY MNDEMPESVR DIKVIETDPA HMDKDVEIVF SSLPADFAAK VEPEYAKDFV VASNASAMRM KKDIPLVIPE VNPQFLDMIE AQQKNNNWDG FIVTNPNCST IALTLTLKPI YDNFNINRIY VSTMQAVSGA GYNGVPSMAI LDNLVPYIGG EEEKMESETL HLLGSLDGDE VVPANFSLSA SCHRVPVIDG HTEAVFVELD EEADIDKIKK TMADFRGLPQ ELGLHSAPEQ PVIVKEEDDR PQPRMDRMAY GGMAATVGRL RKDQAFDNSF KYVLVGHNTI RGAAGASILN AELINKQIL //