ID D2NQR5_ROTMD Unreviewed; 206 AA. AC D2NQR5; DT 02-MAR-2010, integrated into UniProtKB/TrEMBL. DT 02-MAR-2010, sequence version 1. DT 22-FEB-2023, entry version 56. DE RecName: Full=2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase {ECO:0000256|ARBA:ARBA00013253}; DE EC=2.7.6.3 {ECO:0000256|ARBA:ARBA00013253}; GN OrderedLocusNames=RMDY18_01590 {ECO:0000313|EMBL:BAI63991.1}; OS Rothia mucilaginosa (strain DY-18) (Stomatococcus mucilaginosus). OC Bacteria; Actinobacteria; Micrococcales; Micrococcaceae; Rothia. OX NCBI_TaxID=680646 {ECO:0000313|EMBL:BAI63991.1, ECO:0000313|Proteomes:UP000001883}; RN [1] {ECO:0000313|Proteomes:UP000001883} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=DY-18 {ECO:0000313|Proteomes:UP000001883}; RA Yamane K., Nambu T., Mashimo C., Sugimori C., Yamanaka T., Leung K., RA Fukushima H.; RT "Complete genome sequence of Rothia mucilaginosa DJ."; RL Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:BAI63991.1, ECO:0000313|Proteomes:UP000001883} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=DY-18 {ECO:0000313|EMBL:BAI63991.1, RC ECO:0000313|Proteomes:UP000001883}; RA Yamane K., Yoshida M., Fujihira T., Baba T., Tsuji N., Hayashi H., RA Sugimori C., Yamanaka T., Mashimo C., Nambu T., Kawai H., Fukushima H.; RT "Isolation and identification of Rothia mucilaginosa from persistent apical RT periodontitis lesions."; RL J Osaka Dent Univ 44:93-98(2010). RN [3] {ECO:0000313|EMBL:BAI63991.1, ECO:0000313|Proteomes:UP000001883} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=DY-18 {ECO:0000313|EMBL:BAI63991.1, RC ECO:0000313|Proteomes:UP000001883}; RA Yamane K., Nambu T., Yamanaka T., Mashimo C., Sugimori C., Leung K.-P., RA Fukushima H.; RT "Complete Genome Sequence of Rothia mucilaginosa DY-18: A Clinical Isolate RT with Dense Meshwork-Like Structures from a Persistent Apical Periodontitis RT Lesion."; RL Sequencing 2010:457236-457236(2010). CC -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino- CC 4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8- CC dihydroneopterin triphosphate: step 4/4. CC {ECO:0000256|ARBA:ARBA00005051}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP011540; BAI63991.1; -; Genomic_DNA. DR RefSeq; WP_012902772.1; NC_013715.1. DR AlphaFoldDB; D2NQR5; -. DR STRING; 680646.RMDY18_01590; -. DR EnsemblBacteria; BAI63991; BAI63991; RMDY18_01590. DR KEGG; rmu:RMDY18_01590; -. DR eggNOG; COG0801; Bacteria. DR HOGENOM; CLU_097916_0_0_11; -. DR OMA; QVILRQN; -. DR UniPathway; UPA00077; UER00155. DR Proteomes; UP000001883; Chromosome. DR GO; GO:0003848; F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity; IEA:UniProtKB-EC. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW. DR GO; GO:0046656; P:folic acid biosynthetic process; IEA:UniProtKB-KW. DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW. DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway. DR CDD; cd00483; HPPK; 1. DR Gene3D; 3.30.70.560; 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; 1. DR InterPro; IPR000550; Hppk. DR InterPro; IPR035907; Hppk_sf. DR PANTHER; PTHR43071; 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE; 1. DR PANTHER; PTHR43071:SF1; 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE; 1. DR Pfam; PF01288; HPPK; 1. DR SUPFAM; SSF55083; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK; 1. DR TIGRFAMs; TIGR01498; folK; 1. DR PROSITE; PS00794; HPPK; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW Folate biosynthesis {ECO:0000256|ARBA:ARBA00022909}; KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:BAI63991.1}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Reference proteome {ECO:0000313|Proteomes:UP000001883}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}. FT DOMAIN 103..114 FT /note="7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase" FT /evidence="ECO:0000259|PROSITE:PS00794" SQ SEQUENCE 206 AA; 22471 MW; DC2769A4CE417E19 CRC64; MAGTQTTDTQ KPNTLKHRAV LALGSNLGES EDTLERAVAD LVAGGVQLVR ASGLYRTAPV GGPAGQPDFV NAVIEVTTDL GAYELLRLCN AVEAAHHRER LVRWGPRTLD IDVIDYDGVI SEDPVLTLPH PRAQERAFVL VPWAQMDPQA RLTVTHRAKP SGERPDEVPE PLSREVVNVA ELSRTLLGAD EDAISYMREM QVPDQP //