ID D2H0S2_AILME Unreviewed; 697 AA. AC D2H0S2; DT 09-FEB-2010, integrated into UniProtKB/TrEMBL. DT 09-FEB-2010, sequence version 1. DT 24-JUL-2024, entry version 61. DE RecName: Full=Transmembrane protein 168 {ECO:0000256|ARBA:ARBA00014572}; DE Flags: Fragment; GN Name=TMEM168 {ECO:0000313|Ensembl:ENSAMEP00000005937.1}; GN ORFNames=PANDA_003045 {ECO:0000313|EMBL:EFB18131.1}; OS Ailuropoda melanoleuca (Giant panda). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda. OX NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB18131.1}; RN [1] {ECO:0000313|EMBL:EFB18131.1, ECO:0000313|Proteomes:UP000008912} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=20010809; DOI=10.1038/nature08696; RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B., RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J., RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A., RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B., RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W., RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M., RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G., RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C., RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D., RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W., RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L., RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J., RA Wang J.; RT "The sequence and de novo assembly of the giant panda genome."; RL Nature 463:311-317(2010). RN [2] {ECO:0000313|Ensembl:ENSAMEP00000005937.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2024) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Nucleus membrane CC {ECO:0000256|ARBA:ARBA00004232}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004232}. CC -!- SIMILARITY: Belongs to the TMEM168 family. CC {ECO:0000256|ARBA:ARBA00007329}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GL192413; EFB18131.1; -; Genomic_DNA. DR RefSeq; XP_002915089.1; XM_002915043.3. DR RefSeq; XP_019650591.1; XM_019795032.1. DR STRING; 9646.ENSAMEP00000005937; -. DR Ensembl; ENSAMET00000006184.2; ENSAMEP00000005937.1; ENSAMEG00000005625.2. DR GeneID; 100483414; -. DR KEGG; aml:100483414; -. DR CTD; 64418; -. DR eggNOG; ENOG502QRB6; Eukaryota. DR GeneTree; ENSGT00390000005941; -. DR HOGENOM; CLU_032315_0_0_1; -. DR OMA; HWMMYFP; -. DR OrthoDB; 2912019at2759; -. DR TreeFam; TF328518; -. DR Proteomes; UP000008912; Unassembled WGS sequence. DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell. DR GO; GO:0030133; C:transport vesicle; IEA:Ensembl. DR GO; GO:0017080; F:sodium channel regulator activity; IEA:Ensembl. DR CDD; cd21494; TMEM168; 1. DR InterPro; IPR029713; TMEM168. DR PANTHER; PTHR14437; TRANSMEMBRANE PROTEIN 168; 1. DR PANTHER; PTHR14437:SF2; TRANSMEMBRANE PROTEIN 168; 1. PE 3: Inferred from homology; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Reference proteome {ECO:0000313|Proteomes:UP000008912}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 35..56 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 63..85 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 97..114 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 126..145 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 165..192 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 199..217 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 223..243 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 264..283 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 289..319 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 352..375 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT NON_TER 697 FT /evidence="ECO:0000313|EMBL:EFB18131.1" SQ SEQUENCE 697 AA; 79720 MW; BDDE67F1787AF5E4 CRC64; MCKSLRYCFS HCLYLAMTRL EEVNREVNMH SSVRYLGYLA RINLLVAICL GLYVRWEKTA NSLILVIFIL GLFILGIASI LYYYFSMETA SLSLSNLWFG FLLGLLCFLD NSSFKNDVKE ESTKYLLLTS IVLRILCALV ERISGYVHHR PTLLTTVEFL ELVGFAIAST TMLVEKSLSV ILLVVALAML IIDLRMKSFL AIPNLVIFAV LLFFSSLETP KNPVAFACFF ICLITDPFLD IYFSGLSVTE RWKPFLYRGR ICRRLSVVFT GMIELTFFIL SAFKLRDTHL WYFVIPGFSI FGIFWMICHI IFLLTLWGFQ TKLNDCHKVY FTHRVDNNSL DRIMASKGMR HFCLISEQLV FFSLLATAIL GAVSWQPTNG IFLSMFLIVL PLESMAHGLF HELGNCLGGT SVGYAIVIPT NFCSPDGQPT LLPPEHVQEL NLRSTGMLNA IQRFFAYHMI ETYGCDYSTS GLSFDTLHSK LKAFLELRTV DGPRHDTYVL YYSGHTHGTG EWALAGGDVL RLDTLLEWWR EKNASFCSRL IIVLDSENST PWVKEVRKIN DQYIAVQGAE MTKTIDIEEA DPPQLGDFTK DWVEYNCNPS NNICWTEKGR SVKAVYGVSK RWSDYTLHLP TGSDVAKHWM LHFPRITYPL VHLANWLCGL NLFWICKSCF RCLKRLKMSW FLPTVLDTGQ GFKLVKS //