ID   D2H0S2_AILME            Unreviewed;       697 AA.
AC   D2H0S2;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   28-JUN-2023, entry version 56.
DE   RecName: Full=Transmembrane protein 168 {ECO:0000256|ARBA:ARBA00014572};
DE   Flags: Fragment;
GN   Name=TMEM168 {ECO:0000313|Ensembl:ENSAMEP00000005937.1};
GN   ORFNames=PANDA_003045 {ECO:0000313|EMBL:EFB18131.1};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|EMBL:EFB18131.1};
RN   [1] {ECO:0000313|EMBL:EFB18131.1, ECO:0000313|Proteomes:UP000008912}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA   Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA   Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA   Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA   Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA   Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA   Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA   Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA   Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA   Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA   Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA   Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA   Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA   Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA   Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|Ensembl:ENSAMEP00000005937.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Nucleus membrane
CC       {ECO:0000256|ARBA:ARBA00004232}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004232}.
CC   -!- SIMILARITY: Belongs to the TMEM168 family.
CC       {ECO:0000256|ARBA:ARBA00007329}.
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DR   EMBL; GL192413; EFB18131.1; -; Genomic_DNA.
DR   RefSeq; XP_002915089.1; XM_002915043.3.
DR   RefSeq; XP_019650591.1; XM_019795032.1.
DR   STRING; 9646.ENSAMEP00000005937; -.
DR   Ensembl; ENSAMET00000006184.2; ENSAMEP00000005937.1; ENSAMEG00000005625.2.
DR   GeneID; 100483414; -.
DR   KEGG; aml:100483414; -.
DR   CTD; 64418; -.
DR   eggNOG; ENOG502QRB6; Eukaryota.
DR   GeneTree; ENSGT00390000005941; -.
DR   HOGENOM; CLU_032315_0_0_1; -.
DR   OMA; ERICGCI; -.
DR   OrthoDB; 2912019at2759; -.
DR   TreeFam; TF328518; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030133; C:transport vesicle; IEA:Ensembl.
DR   GO; GO:0017080; F:sodium channel regulator activity; IEA:Ensembl.
DR   CDD; cd21494; TMEM168; 1.
DR   InterPro; IPR029713; TMEM168.
DR   PANTHER; PTHR14437; TRANSMEMBRANE PROTEIN 168; 1.
DR   PANTHER; PTHR14437:SF2; TRANSMEMBRANE PROTEIN 168; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        35..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        63..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        97..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        126..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        165..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        199..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        264..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        289..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        352..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   NON_TER         697
FT                   /evidence="ECO:0000313|EMBL:EFB18131.1"
SQ   SEQUENCE   697 AA;  79720 MW;  BDDE67F1787AF5E4 CRC64;
     MCKSLRYCFS HCLYLAMTRL EEVNREVNMH SSVRYLGYLA RINLLVAICL GLYVRWEKTA
     NSLILVIFIL GLFILGIASI LYYYFSMETA SLSLSNLWFG FLLGLLCFLD NSSFKNDVKE
     ESTKYLLLTS IVLRILCALV ERISGYVHHR PTLLTTVEFL ELVGFAIAST TMLVEKSLSV
     ILLVVALAML IIDLRMKSFL AIPNLVIFAV LLFFSSLETP KNPVAFACFF ICLITDPFLD
     IYFSGLSVTE RWKPFLYRGR ICRRLSVVFT GMIELTFFIL SAFKLRDTHL WYFVIPGFSI
     FGIFWMICHI IFLLTLWGFQ TKLNDCHKVY FTHRVDNNSL DRIMASKGMR HFCLISEQLV
     FFSLLATAIL GAVSWQPTNG IFLSMFLIVL PLESMAHGLF HELGNCLGGT SVGYAIVIPT
     NFCSPDGQPT LLPPEHVQEL NLRSTGMLNA IQRFFAYHMI ETYGCDYSTS GLSFDTLHSK
     LKAFLELRTV DGPRHDTYVL YYSGHTHGTG EWALAGGDVL RLDTLLEWWR EKNASFCSRL
     IIVLDSENST PWVKEVRKIN DQYIAVQGAE MTKTIDIEEA DPPQLGDFTK DWVEYNCNPS
     NNICWTEKGR SVKAVYGVSK RWSDYTLHLP TGSDVAKHWM LHFPRITYPL VHLANWLCGL
     NLFWICKSCF RCLKRLKMSW FLPTVLDTGQ GFKLVKS
//