ID D1LUZ4_HUMAN Unreviewed; 110 AA. AC D1LUZ4; DT 19-JAN-2010, integrated into UniProtKB/TrEMBL. DT 19-JAN-2010, sequence version 1. DT 24-JUL-2024, entry version 47. DE SubName: Full=RUNX1/CBFA2T2 fusion protein type 2 {ECO:0000313|EMBL:ACY95287.1}; DE Flags: Fragment; GN Name=RUNX1/CBFA2T2 fusion {ECO:0000313|EMBL:ACY95287.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ACY95287.1}; RN [1] {ECO:0000313|EMBL:ACY95287.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Bone marrow/blood {ECO:0000313|EMBL:ACY95287.1}; RA Guastadisegni M.C., Lonoce A., Impera L., Fugazza G., Aliano S., Grasso R., RA Raynaud S., Rocchi M., Storlazzi C.T.; RT "Two novel fusions involving RUNX1 in acute myeloid leukemia with a RT t(20;21) translocation: CBFA2T2 and C20orf112."; RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GU070939; ACY95287.1; -; mRNA. DR AlphaFoldDB; D1LUZ4; -. DR PeptideAtlas; D1LUZ4; -. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:TreeGrafter. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter. DR GO; GO:0002062; P:chondrocyte differentiation; IEA:TreeGrafter. DR GO; GO:0030097; P:hemopoiesis; IEA:TreeGrafter. DR GO; GO:0030182; P:neuron differentiation; IEA:TreeGrafter. DR GO; GO:0001503; P:ossification; IEA:TreeGrafter. DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:UniProt. DR GO; GO:0045595; P:regulation of cell differentiation; IEA:TreeGrafter. DR Gene3D; 2.60.40.720; -; 1. DR InterPro; IPR000040; AML1_Runt. DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf. DR InterPro; IPR012346; p53/RUNT-type_TF_DNA-bd_sf. DR InterPro; IPR013524; Runt_dom. DR PANTHER; PTHR11950; RUNT RELATED; 1. DR PANTHER; PTHR11950:SF40; RUNT-RELATED TRANSCRIPTION FACTOR 1; 1. DR Pfam; PF00853; Runt; 1. DR SUPFAM; SSF49417; p53-like transcription factors; 1. DR PROSITE; PS51062; RUNT; 1. PE 2: Evidence at transcript level; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}. FT DOMAIN 1..33 FT /note="Runt" FT /evidence="ECO:0000259|PROSITE:PS51062" FT REGION 25..50 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 62..110 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 25..41 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 77..97 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:ACY95287.1" FT NON_TER 110 FT /evidence="ECO:0000313|EMBL:ACY95287.1" SQ SEQUENCE 110 AA; 12353 MW; 77E5773123372D7C CRC64; FTLTITVFTN PPQVATYHRA IKITVDGPRE PRRHRQKLDD QTKPGSLSFS ERLSELEQLR RTAMRVSPHH PAPTPNPRAS LNHSTAFNPQ PQSQMQVGPE KRVPAMPGSP //