ID D1LUZ4_HUMAN Unreviewed; 110 AA. AC D1LUZ4; DT 19-JAN-2010, integrated into UniProtKB/TrEMBL. DT 19-JAN-2010, sequence version 1. DT 11-NOV-2015, entry version 25. DE SubName: Full=RUNX1/CBFA2T2 fusion protein type 2 {ECO:0000313|EMBL:ACY95287.1}; DE Flags: Fragment; GN Name=RUNX1/CBFA2T2 fusion {ECO:0000313|EMBL:ACY95287.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ACY95287.1}; RN [1] {ECO:0000313|EMBL:ACY95287.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Bone marrow/blood {ECO:0000313|EMBL:ACY95287.1}; RA Guastadisegni M.C., Lonoce A., Impera L., Fugazza G., Aliano S., RA Grasso R., Raynaud S., Rocchi M., Storlazzi C.T.; RT "Two novel fusions involving RUNX1 in acute myeloid leukemia with a RT t(20;21) translocation: CBFA2T2 and C20orf112."; RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GU070939; ACY95287.1; -; mRNA. DR STRING; 9606.ENSP00000300305; -. DR BindingDB; D1LUZ4; -. DR PaxDb; D1LUZ4; -. DR eggNOG; KOG3982; Eukaryota. DR eggNOG; ENOG4111J4Y; LUCA. DR NextBio; 35489131; -. DR GO; GO:0005634; C:nucleus; IEA:InterPro. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0003677; F:DNA binding; IEA:InterPro. DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro. DR Gene3D; 2.60.40.720; -; 1. DR InterPro; IPR000040; AML1_Runt. DR InterPro; IPR008967; p53-like_TF_DNA-bd. DR InterPro; IPR012346; p53/RUNT-type_TF_DNA-bd. DR InterPro; IPR013524; Runt_dom. DR PANTHER; PTHR11950; PTHR11950; 1. DR Pfam; PF00853; Runt; 1. DR SUPFAM; SSF49417; SSF49417; 1. DR PROSITE; PS51062; RUNT; 1. PE 2: Evidence at transcript level; FT NON_TER 1 1 {ECO:0000313|EMBL:ACY95287.1}. FT NON_TER 110 110 {ECO:0000313|EMBL:ACY95287.1}. SQ SEQUENCE 110 AA; 12353 MW; 77E5773123372D7C CRC64; FTLTITVFTN PPQVATYHRA IKITVDGPRE PRRHRQKLDD QTKPGSLSFS ERLSELEQLR RTAMRVSPHH PAPTPNPRAS LNHSTAFNPQ PQSQMQVGPE KRVPAMPGSP //