ID D1LN57_9INFA Unreviewed; 568 AA. AC D1LN57; DT 19-JAN-2010, integrated into UniProtKB/TrEMBL. DT 19-JAN-2010, sequence version 1. DT 02-MAR-2010, entry version 3. DE SubName: Full=Hemagglutinin; GN Name=HA; OS Influenza A virus (A/Hong Kong/485/1997(H5N1)). OC Viruses; ssRNA negative-strand viruses; Orthomyxoviridae; OC Influenzavirus A. OX NCBI_TaxID=680692; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/Hong Kong/485/1997; RA Kim L.M., Scott M.A., Suarez D.L., Spackman E., Swayne D.E., RA Afonso C.L.; RT "USDA Agriculture Research Service Avian Influenza Virus Sequencing RT Project."; RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Binds to sialic acid-containing receptors on the cell CC surface, bringing about the attachment of the virus particle to CC the cell. Plays a major role in the determination of host range CC restriction and virulence. Class I viral fusion protein. CC Responsible for penetration of the virus into the cell cytoplasm CC by mediating the fusion of the membrane of the endocytosed virus CC particle with the endosomal membrane. Low pH in endosomes induce CC an irreversible conformational change in HA2, releasing the fusion CC hydrophobic peptide. Several trimers are required to form a CC competent fusion pore (By similarity). CC -!- SUBUNIT: Homotrimer of disulfide-linked HA1-HA2 (By similarity). CC -!- SIMILARITY: Belongs to the influenza viruses hemagglutinin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GU052142; ACZ48514.1; -; Viral_cRNA. DR GO; GO:0019031; C:viral envelope; IEA:InterPro. DR GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro. DR GO; GO:0019064; P:viral envelope fusion with host membrane; IEA:InterPro. DR InterPro; IPR008980; Capsid_hemagglutn. DR InterPro; IPR013827; Hemagglutn_HA1_b-rbn_dom. DR InterPro; IPR000149; Hemagglutn_influenz_HA1. DR InterPro; IPR001364; Hemagglutn_influenz_HA1/HA2. DR InterPro; IPR013829; Hemagglutn_stalk. DR Gene3D; G3DSA:2.10.77.10; Haemagglutn_HA1_b-ribbon; 1. DR Gene3D; G3DSA:3.90.20.10; Haemagglutn_stalk; 1. DR Pfam; PF00509; Hemagglutinin; 1. DR PRINTS; PR00330; HEMAGGLUTN1. DR PRINTS; PR00329; HEMAGGLUTN12. DR SUPFAM; SSF49818; Capsid_hemag; 1. PE 3: Inferred from homology; KW Envelope protein; Fusion protein; Hemagglutinin; Host cell membrane; KW Host membrane; Membrane; Transmembrane; Virion. SQ SEQUENCE 568 AA; 64333 MW; 18DA3277E61EA162 CRC64; MEKIVLLLAT VSLVKSDQIC IGYHANNSTE QVDTIMEKNV TVTHAQDILE RTHNGKLCDL NGVKPLILRD CSVAGWLLGN PMCDEFINVP EWSYIVEKAS PANDLCYPGN FNDYEELKHL LSRINHFEKI QIIPKSSWSN HDASSGVSSA CPYLGRSSFF RNVVWLIKKN SSYPTIKRSY NNTNQEDLLV LWGIHHPNDA AEQTRLYQNP TTYISVGTST LNQRLVPEIA TRPKVNGQSG RMEFFWTILK PNDAINFESN GNFIAPEYAY KIVKKGDSTI MKSELEYGNC NTKCQTPMGA INSSMPFHNI HPLTIGECPK YVKSNRLVLA TGLRNTPQRE RRRKKRGLFG AIAGFIEGGW QGMVDGWYGY HHSNEQGSGY AADQESTQKA IDGVTNKVNS IINKMNTQFE AVGREFNNLE RRIENLNKKM EDGFLDVWTY NAELLVLMEN ERTLDFHDSN VKNLYDKVRL QLRDNAKELG NGCFEFYHKC DNECMESVKN GTYDYPQYSE EARLNREEIS GVKLESMGTY QILSIYSTVA SSLALAIMVA GLSLWMCSNG SLQCRICI //