ID D0U4N0_9GAMM Unreviewed; 341 AA. AC D0U4N0; DT 15-DEC-2009, integrated into UniProtKB/TrEMBL. DT 15-DEC-2009, sequence version 1. DT 19-OCT-2011, entry version 13. DE SubName: Full=Aspartate-semialdehyde dehydrogenase; GN ORFNames=Sup05_1334, SUP05_FGYC65E210007; OS uncultured SUP05 cluster bacterium. OC Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales; OC unclassified Oceanospirillales; SUP05 cluster; environmental samples. OX NCBI_TaxID=655186; RN [1] RP NUCLEOTIDE SEQUENCE. RA Walsh D.A., Zaikova E., Howes C.L., Song Y.C., Wright J.J., RA Tringe S.G., Tortell P.D., Hallam S.J.; RT "Metagenome of a versatile chemolithoautotroph from expanding oxygen RT minimum zones."; RL Science 326:578-582(2009). RN [2] RP NUCLEOTIDE SEQUENCE. RX PubMed=19900896; DOI=10.1126/science.1175309; RA Walsh D.A., Zaikova E., Howes C.G., Song Y.C., Wright J.J., RA Tringe S.G., Tortell P.D., Hallam S.J.; RT "Metagenome of a versatile chemolithoautotroph from expanding oceanic RT dead zones."; RL Science 326:578-582(2009). CC -!- SIMILARITY: Belongs to the aspartate-semialdehyde dehydrogenase CC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GQ351269; ACX30562.1; -; Genomic_DNA. DR EMBL; GG730003; EEZ80090.1; -; Genomic_DNA. DR ProteinModelPortal; D0U4N0; -. DR GO; GO:0005737; C:cytoplasm; IEA:InterPro. DR GO; GO:0004073; F:aspartate-semialdehyde dehydrogenase activity; IEA:InterPro. DR GO; GO:0003942; F:N-acetyl-gamma-glutamyl-phosphate reductase activity; IEA:InterPro. DR GO; GO:0051287; F:NAD binding; IEA:InterPro. DR GO; GO:0050661; F:NADP binding; IEA:InterPro. DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro. DR GO; GO:0009097; P:isoleucine biosynthetic process; IEA:InterPro. DR GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:InterPro. DR GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro. DR GO; GO:0009088; P:threonine biosynthetic process; IEA:InterPro. DR InterPro; IPR012080; Asp_semialdehyde_DH. DR InterPro; IPR005986; Asp_semialdehyde_DH_bac. DR InterPro; IPR016040; NAD(P)-bd_dom. DR InterPro; IPR000534; Semialdehyde_DH_NAD-bd. DR InterPro; IPR012280; Semialdhyde_DH_dimer_dom. DR Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1. DR Pfam; PF01118; Semialdhyde_dh; 1. DR Pfam; PF02774; Semialdhyde_dhC; 1. DR PIRSF; PIRSF000148; ASA_dh; 1. DR SMART; SM00859; Semialdhyde_dh; 1. DR TIGRFAMs; TIGR01296; Asd_B; 1. PE 3: Inferred from homology; FT ACT_SITE 132 132 Acyl-thioester intermediate (By FT similarity). SQ SEQUENCE 341 AA; 37274 MW; 79A54BF5014C0711 CRC64; MSKKYNVAVV GATGAVGETI LSILEQRNFP IDNLYPLASA NSAGKKVFCQ GKSWTVQDLD TFDFSQAQIG LFSAGGNISE KYAPIAAEAG CVVIDNTAHF RRDEGIPLVV PEVNPHAISG YTKRNIIANP NCSTIQMLVA LKPIYDAVGI ERINVATYQA VSGSGKEAIS ELIEQTTKLL GGNTEVDVEV YPKQIAFNVI PHIDVFQDNG YTKEEMKMVW ETQKIFEDDN ILVNPTAVRV PVIYGHSEAI NIETKTKITA AEAVEVLSKA NGVTVLDKRE DGGYATPFVE ATNHDDTFVS RIREDISHEK GLNLWVVSDN IRKGAALNSI QIAEILIEEY L //