ID CRE6_PHYIT Reviewed; 127 AA. AC D0N8F5; DT 08-MAY-2019, integrated into UniProtKB/Swiss-Prot. DT 15-DEC-2009, sequence version 1. DT 03-AUG-2022, entry version 35. DE RecName: Full=RxLR effector protein CRE6 {ECO:0000303|PubMed:29312401}; DE AltName: Full=Core RXLR effector 6 {ECO:0000303|PubMed:29312401}; DE Flags: Precursor; GN Name=CRE6 {ECO:0000303|PubMed:29312401}; ORFNames=PITG_07451; OS Phytophthora infestans (strain T30-4) (Potato late blight agent). OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae; OC Phytophthora. OX NCBI_TaxID=403677; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=T30-4; RX PubMed=19741609; DOI=10.1038/nature08358; RG The Broad Institute Genome Sequencing Platform; RA Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M., RA Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O., RA Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A., RA Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V., RA Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S., RA Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S., RA Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K., RA Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D., RA Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L., RA Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J., RA Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M., RA Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S., RA Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D., RA Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J., RA Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S., RA Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P., RA Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S., RA Nusbaum C.; RT "Genome sequence and analysis of the Irish potato famine pathogen RT Phytophthora infestans."; RL Nature 461:393-398(2009). RN [2] RP INDUCTION, DOMAIN, AND FUNCTION. RX PubMed=29312401; DOI=10.3389/fpls.2017.02155; RA Yin J., Gu B., Huang G., Tian Y., Quan J., Lindqvist-Kreuze H., Shan W.; RT "Conserved RXLR effector genes of Phytophthora infestans expressed at the RT early stage of potato infection are suppressive to host defense."; RL Front. Plant Sci. 8:2155-2155(2017). CC -!- FUNCTION: Effector that is involved in host plant infection. CC Contributes to virulence during the early infection stage, by CC inhibiting plant defense responses induced by both PAMP-triggered CC immunity (PTI) and effector-triggered immunity (ETI). CC {ECO:0000269|PubMed:29312401}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:29312401}. Host cell CC {ECO:0000305|PubMed:29312401}. CC -!- INDUCTION: Expression is induced during host plant infection. CC {ECO:0000269|PubMed:29312401}. CC -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host CC cell cytoplasm through binding to cell surface phosphatidylinositol-3- CC phosphate. {ECO:0000305|PubMed:29312401}. CC -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DS028128; EEY53840.1; -; Genomic_DNA. DR RefSeq; XP_002904471.1; XM_002904425.1. DR AlphaFoldDB; D0N8F5; -. DR EnsemblProtists; PITG_07451T0; PITG_07451T0; PITG_07451. DR GeneID; 9465678; -. DR KEGG; pif:PITG_07451; -. DR VEuPathDB; FungiDB:PITG_07451; -. DR eggNOG; ENOG502RGN3; Eukaryota. DR HOGENOM; CLU_161018_0_0_1; -. DR InParanoid; D0N8F5; -. DR OMA; IRTGMAN; -. DR OrthoDB; 1639238at2759; -. DR Proteomes; UP000006643; Partially assembled WGS sequence. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0043657; C:host cell; IEA:UniProtKB-SubCell. PE 2: Evidence at transcript level; KW Reference proteome; Secreted; Signal; Virulence. FT SIGNAL 1..19 FT /evidence="ECO:0000255" FT CHAIN 20..127 FT /note="RxLR effector protein CRE6" FT /id="PRO_5003011777" FT MOTIF 48..67 FT /note="RxLR-dEER" FT /evidence="ECO:0000305|PubMed:29312401" SQ SEQUENCE 127 AA; 14115 MW; 4AE291E0A5D82DB6 CRC64; MIRNALLVLV FVLIGTISAA TDADMTTDSG KQPSNINQLT LVSPEGKRLL RQGSVKEGGV HDATEERAFI VTPLKNSLYR ILAAFGLKPQ TLYVQLGIRT GMANALYNRL YHSYHRWYAT YGPRVYG //