ID D0FHX1_9INFA Unreviewed; 62 AA. AC D0FHX1; DT 24-NOV-2009, integrated into UniProtKB/TrEMBL. DT 24-NOV-2009, sequence version 1. DT 15-JUN-2010, entry version 5. DE SubName: Full=Matrix protein 2; DE Flags: Fragment; GN Name=M2; OS Influenza A virus (A/Chengdu/03/2009(H1N1)). OC Viruses; ssRNA negative-strand viruses; Orthomyxoviridae; OC Influenzavirus A. OX NCBI_TaxID=681159; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/Chengdu/03/2009; RA Jiang T., Qin C., Li X., Zhao H., Yu M., Deng Y., Yu X., Han J., RA Qin E., Zhu Q.; RT "A community transmission of influenza A (H1N1) virus in a boarding RT school in China, 22-27 July 2009."; RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Forms a proton-selective ion channel that is necessary CC for the efficient release of the viral genome during virus entry. CC After attaching to the cell surface, the virion enters the cell by CC endocytosis. Acidification of the endosome triggers M2 ion channel CC activity. The influx of protons into virion interior is believed CC to disrupt interactions between the viral ribonucleoprotein (RNP), CC matrix protein 1 (M1), and lipid bilayers, thereby freeing the CC viral genome from interaction with viral proteins and enabling RNA CC segments to migrate to the host cell nucleus, where influenza CC virus RNA transcription and replication occur. Also plays a role CC in viral proteins secretory pathway. Elevates the intravesicular CC pH of normally acidic compartments, such as trans-Golgi network, CC preventing newly formed hemagglutinin from premature switching to CC the fusion-active conformation (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GU056984; ACX47411.1; -; Viral_cRNA. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:InterPro. DR GO; GO:0015078; F:hydrogen ion transmembrane transporter acti...; IEA:InterPro. DR GO; GO:0005216; F:ion channel activity; IEA:UniProtKB-KW. DR GO; GO:0015992; P:proton transport; IEA:UniProtKB-KW. DR InterPro; IPR002089; Flu_M2. DR Pfam; PF00599; Flu_M2; 1. PE 3: Inferred from homology; KW Host cell membrane; Host membrane; Hydrogen ion transport; KW Ion transport; Ionic channel; Membrane; Transmembrane; Transport; KW Virion. FT NON_TER 1 1 FT NON_TER 62 62 SQ SEQUENCE 62 AA; 7156 MW; 28048D6BEEF42A1A CRC64; PTRSEWECRC SDSSDPLVIA ANIIGILHLI LWITDRLFFK CIYRRFKYGL KRGPSTEGVP ES //