ID   D0FHX1_9INFA            Unreviewed;        62 AA.
AC   D0FHX1;
DT   24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   24-NOV-2009, sequence version 1.
DT   19-MAR-2014, entry version 15.
DE   SubName: Full=Matrix protein 2;
DE   Flags: Fragment;
GN   Name=M2;
OS   Influenza A virus (A/Chengdu/03/2009(H1N1)).
OC   Viruses; ssRNA negative-strand viruses; Orthomyxoviridae;
OC   Influenzavirus A.
OX   NCBI_TaxID=681159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=A/Chengdu/03/2009;
RA   Jiang T., Qin C., Li X., Zhao H., Yu M., Deng Y., Yu X., Han J.,
RA   Qin E., Zhu Q.;
RT   "A community transmission of influenza A (H1N1) virus in a boarding
RT   school in China, 22-27 July 2009.";
RL   Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Forms a proton-selective ion channel that is necessary
CC       for the efficient release of the viral genome during virus entry.
CC       After attaching to the cell surface, the virion enters the cell by
CC       endocytosis. Acidification of the endosome triggers M2 ion channel
CC       activity. The influx of protons into virion interior is believed
CC       to disrupt interactions between the viral ribonucleoprotein (RNP),
CC       matrix protein 1 (M1), and lipid bilayers, thereby freeing the
CC       viral genome from interaction with viral proteins and enabling RNA
CC       segments to migrate to the host cell nucleus, where influenza
CC       virus RNA transcription and replication occur. Also plays a role
CC       in viral proteins secretory pathway. Elevates the intravesicular
CC       pH of normally acidic compartments, such as trans-Golgi network,
CC       preventing newly formed hemagglutinin from premature switching to
CC       the fusion-active conformation (By similarity).
CC   -!- SUBCELLULAR LOCATION: Virion membrane. Host apical cell membrane;
CC       Single-pass type III membrane protein (By similarity).
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DR   EMBL; GU056984; ACX47411.1; -; Viral_cRNA.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:1902600; P:hydrogen ion transmembrane transport; IEA:GOC.
DR   InterPro; IPR002089; Flu_M2.
DR   Pfam; PF00599; Flu_M2; 1.
DR   ProDom; PD001031; Flu_M2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Host cell membrane; Host membrane;
KW   Hydrogen ion transport; Ion channel; Ion transport; Membrane;
KW   Phosphoprotein; Transmembrane; Transmembrane helix; Transport; Virion.
FT   NON_TER       1      1
FT   NON_TER      62     62
SQ   SEQUENCE   62 AA;  7156 MW;  28048D6BEEF42A1A CRC64;
     PTRSEWECRC SDSSDPLVIA ANIIGILHLI LWITDRLFFK CIYRRFKYGL KRGPSTEGVP
     ES
//