ID D0EW11_MOUSE Unreviewed; 145 AA. AC D0EW11; DT 24-NOV-2009, integrated into UniProtKB/TrEMBL. DT 24-NOV-2009, sequence version 1. DT 02-DEC-2020, entry version 82. DE SubName: Full=Multiple coagulation factor deficiency 2 isoform 1 {ECO:0000313|EMBL:ACX48448.1}; GN Name=Mcfd2 {ECO:0000313|EMBL:ACX48448.1, ECO:0000313|MGI:MGI:2183439}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:ACX48448.1}; RN [1] {ECO:0000313|EMBL:ACX48448.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/J {ECO:0000313|EMBL:ACX48449.1}, and C57BL/6J RC {ECO:0000313|EMBL:ACX48448.1}; RA Sa Q., Hoover-Plow J.; RT "Nucleotide polymorphisms in Mcfd2 gene in A/J and C57BL/6J mice."; RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000213|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GQ896355; ACX48448.1; -; mRNA. DR EMBL; GQ896356; ACX48449.1; -; mRNA. DR RefSeq; NP_647456.1; NM_139295.3. DR RefSeq; NP_789778.1; NM_176808.5. DR RefSeq; XP_006523964.1; XM_006523901.3. DR SMR; D0EW11; -. DR PeptideAtlas; D0EW11; -. DR Antibodypedia; 29996; 178 antibodies. DR GeneID; 193813; -. DR KEGG; mmu:193813; -. DR CTD; 90411; -. DR MGI; MGI:2183439; Mcfd2. DR HOGENOM; CLU_100744_1_0_1; -. DR OMA; LDRNMVQ; -. DR OrthoDB; 1601131at2759; -. DR BioGRID-ORCS; 193813; 0 hits in 17 CRISPR screens. DR ChiTaRS; Mcfd2; mouse. DR Bgee; ENSMUSG00000024150; Expressed in pancreas and 309 other tissues. DR ExpressionAtlas; D0EW11; baseline and differential. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR InterPro; IPR011992; EF-hand-dom_pair. DR InterPro; IPR018247; EF_Hand_1_Ca_BS. DR InterPro; IPR002048; EF_hand_dom. DR Pfam; PF13499; EF-hand_7; 1. DR SUPFAM; SSF47473; SSF47473; 1. DR PROSITE; PS00018; EF_HAND_1; 1. DR PROSITE; PS50222; EF_HAND_2; 2. PE 1: Evidence at protein level; KW Calcium {ECO:0000256|PROSITE-ProRule:PRU00448}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..26 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 27..145 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5010111017" FT DOMAIN 67..102 FT /note="EF-hand" FT /evidence="ECO:0000259|PROSITE:PS50222" FT DOMAIN 115..145 FT /note="EF-hand" FT /evidence="ECO:0000259|PROSITE:PS50222" FT CA_BIND 128..139 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00448" SQ SEQUENCE 145 AA; 16168 MW; EB654BA9B76E0269 CRC64; MATLQLLRAP LLCVLLWVFC APGARAHDHG ADVHHGSVGL DKSTVHDQEH IMEHLEGVID QPEAEMSPQE LQLHYFKMHD YDGNSLLDGL ELSIAITHVH KEEGSEQAPV MSEDELVSII DGVLRDDDKN NDGYIDYAEF AKSLQ //