ID D0EW11_MOUSE Unreviewed; 145 AA. AC D0EW11; DT 24-NOV-2009, integrated into UniProtKB/TrEMBL. DT 24-NOV-2009, sequence version 1. DT 09-DEC-2015, entry version 49. DE SubName: Full=Multiple coagulation factor deficiency 2 isoform 1 {ECO:0000313|EMBL:ACX48448.1}; DE SubName: Full=Multiple coagulation factor deficiency 2, isoform CRA_a {ECO:0000313|EMBL:EDL38625.1}; DE SubName: Full=Multiple coagulation factor deficiency protein 2 homolog {ECO:0000313|Ensembl:ENSMUSP00000024963}; GN Name=Mcfd2 {ECO:0000313|EMBL:ACX48448.1, GN ECO:0000313|Ensembl:ENSMUSP00000024963, ECO:0000313|MGI:MGI:2183439}; GN ORFNames=mCG_15895 {ECO:0000313|EMBL:EDL38625.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] {ECO:0000313|EMBL:EDL38625.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL38625.1}; RX PubMed=12040188; DOI=10.1126/science.1069193; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., RA Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., RA Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W., RA Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., RA Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., RA Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., RA Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., RA Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., RA Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., RA Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., RA Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., RA Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., RA Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., RA Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., RA Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., RA Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., RA Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., RA Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., RA Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., RA Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., RA Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., RA Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., RA Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., RA Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., RA Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., RA Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., RA Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., RA Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., RA Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., RA Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., RA Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., RA Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.; RT "A comparison of whole-genome shotgun-derived mouse chromosome 16 and RT the human genome."; RL Science 296:1661-1671(2002). RN [2] {ECO:0000313|EMBL:EDL38625.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed {ECO:0000313|EMBL:EDL38625.1}; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSMUSP00000024963, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000024963, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [4] {ECO:0000313|EMBL:ACX48448.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/J {ECO:0000313|EMBL:ACX48449.1}, and C57BL/6J RC {ECO:0000313|EMBL:ACX48448.1}; RA Sa Q., Hoover-Plow J.; RT "Nucleotide polymorphisms in Mcfd2 gene in A/J and C57BL/6J mice."; RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|Ensembl:ENSMUSP00000024963} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000024963}; RG Ensembl; RL Submitted (AUG-2015) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC084383; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; GQ896355; ACX48448.1; -; mRNA. DR EMBL; GQ896356; ACX48449.1; -; mRNA. DR EMBL; CH466537; EDL38625.1; -; Genomic_DNA. DR EMBL; CH466537; EDL38627.1; -; Genomic_DNA. DR RefSeq; NP_647456.1; NM_139295.3. DR RefSeq; NP_789778.1; NM_176808.5. DR RefSeq; XP_006523964.1; XM_006523901.2. DR UniGene; Mm.30251; -. DR STRING; 10090.ENSMUSP00000024963; -. DR Ensembl; ENSMUST00000024963; ENSMUSP00000024963; ENSMUSG00000024150. DR Ensembl; ENSMUST00000129616; ENSMUSP00000123352; ENSMUSG00000024150. DR Ensembl; ENSMUST00000144236; ENSMUSP00000121820; ENSMUSG00000024150. DR GeneID; 193813; -. DR KEGG; mmu:193813; -. DR CTD; 90411; -. DR MGI; MGI:2183439; Mcfd2. DR eggNOG; ENOG41124J6; LUCA. DR eggNOG; KOG4065; Eukaryota. DR HOGENOM; HOG000113497; -. DR OMA; ISHVHKE; -. DR ChiTaRS; Mcfd2; mouse. DR NextBio; 371520; -. DR Proteomes; UP000000589; Chromosome 17. DR GO; GO:0005576; C:extracellular region; ISA:MGI. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0019752; P:carboxylic acid metabolic process; ISA:MGI. DR Gene3D; 1.10.238.10; -; 1. DR InterPro; IPR011992; EF-hand-dom_pair. DR InterPro; IPR018247; EF_Hand_1_Ca_BS. DR InterPro; IPR002048; EF_hand_dom. DR Pfam; PF13499; EF-hand_7; 1. DR SUPFAM; SSF47473; SSF47473; 1. DR PROSITE; PS00018; EF_HAND_1; 1. DR PROSITE; PS50222; EF_HAND_2; 2. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Proteomics identification {ECO:0000213|MaxQB:D0EW11, KW ECO:0000213|PeptideAtlas:D0EW11}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 26 {ECO:0000256|SAM:SignalP}. FT CHAIN 27 145 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5005669650. FT DOMAIN 67 102 EF-hand. {ECO:0000259|PROSITE:PS50222}. FT DOMAIN 115 145 EF-hand. {ECO:0000259|PROSITE:PS50222}. SQ SEQUENCE 145 AA; 16168 MW; EB654BA9B76E0269 CRC64; MATLQLLRAP LLCVLLWVFC APGARAHDHG ADVHHGSVGL DKSTVHDQEH IMEHLEGVID QPEAEMSPQE LQLHYFKMHD YDGNSLLDGL ELSIAITHVH KEEGSEQAPV MSEDELVSII DGVLRDDDKN NDGYIDYAEF AKSLQ //