ID C9ZTL6_TRYB9 Unreviewed; 659 AA. AC C9ZTL6; DT 24-NOV-2009, integrated into UniProtKB/TrEMBL. DT 24-NOV-2009, sequence version 1. DT 02-DEC-2020, entry version 40. DE RecName: Full=Glutamine--fructose-6-phosphate transaminase (isomerizing) {ECO:0000256|ARBA:ARBA00012916}; DE EC=2.6.1.16 {ECO:0000256|ARBA:ARBA00012916}; GN ORFNames=TbgDal_VII6450 {ECO:0000313|EMBL:CBH12751.1}; OS Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972). OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina; OC Trypanosomatida; Trypanosomatidae; Trypanosoma. OX NCBI_TaxID=679716 {ECO:0000313|EMBL:CBH12751.1, ECO:0000313|Proteomes:UP000002316}; RN [1] {ECO:0000313|Proteomes:UP000002316} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MHOM/CI/86/DAL972 {ECO:0000313|Proteomes:UP000002316}; RX PubMed=20404998; DOI=10.1371/journal.pntd.0000658; RA Jackson A.P., Sanders M., Berry A., McQuillan J., Aslett M.A., Quail M.A., RA Chukualim B., Capewell P., MacLeod A., Melville S.E., Gibson W., RA Barry J.D., Berriman M., Hertz-Fowler C.; RT "The genome sequence of Trypanosoma brucei gambiense, causative agent of RT chronic human african trypanosomiasis."; RL PLoS Negl. Trop. Dis. 4:E658-E658(2010). CC -!- CATALYTIC ACTIVITY: CC Reaction=D-fructose 6-phosphate + L-glutamine = D-glucosamine 6- CC phosphate + L-glutamate; Xref=Rhea:RHEA:13237, ChEBI:CHEBI:29985, CC ChEBI:CHEBI:58359, ChEBI:CHEBI:58725, ChEBI:CHEBI:61527; EC=2.6.1.16; CC Evidence={ECO:0000256|ARBA:ARBA00001031}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FN554970; CBH12751.1; -; Genomic_DNA. DR RefSeq; XP_011775031.1; XM_011776729.1. DR GeneID; 23862917; -. DR KEGG; tbg:TbgDal_VII6450; -. DR OrthoDB; 262871at2759; -. DR Proteomes; UP000002316; Chromosome 7. DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro. DR GO; GO:0004360; F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity; IEA:UniProtKB-EC. DR GO; GO:1901137; P:carbohydrate derivative biosynthetic process; IEA:InterPro. DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW. DR CDD; cd05008; SIS_GlmS_GlmD_1; 1. DR CDD; cd05009; SIS_GlmS_GlmD_2; 1. DR Gene3D; 3.60.20.10; -; 1. DR InterPro; IPR017932; GATase_2_dom. DR InterPro; IPR035466; GlmS/AgaS_SIS. DR InterPro; IPR035490; GlmS/FrlB_SIS. DR InterPro; IPR005855; GlmS_trans. DR InterPro; IPR029055; Ntn_hydrolases_N. DR InterPro; IPR001347; SIS. DR PANTHER; PTHR10937:SF0; PTHR10937:SF0; 1. DR Pfam; PF01380; SIS; 2. DR SUPFAM; SSF56235; SSF56235; 1. DR TIGRFAMs; TIGR01135; glmS; 1. DR PROSITE; PS51278; GATASE_TYPE_2; 1. DR PROSITE; PS51464; SIS; 2. PE 4: Predicted; KW Aminotransferase {ECO:0000313|EMBL:CBH12751.1}; KW Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CBH12751.1}. FT DOMAIN 2..253 FT /note="Glutamine amidotransferase type-2" FT /evidence="ECO:0000259|PROSITE:PS51278" FT DOMAIN 322..464 FT /note="SIS" FT /evidence="ECO:0000259|PROSITE:PS51464" FT DOMAIN 508..649 FT /note="SIS" FT /evidence="ECO:0000259|PROSITE:PS51464" SQ SEQUENCE 659 AA; 71507 MW; 78DB48C1194D6EC3 CRC64; MCGIFGYILH RIPCTTRDVL NVLLDSLQRM EYRGYDSAGL CVDDVKSKKH IVVRSVGNIS KLRERVFSGC ADLDFNAQLE NHEGIAHTRW ATHGPPSEAN CHPQASNNME FVVVHNGIIT NFMTIKQMLL EEGYHFSSDT DTEVIVVLAE HIFSKDHSIS FADLAGKVMA ELDGAYALLI KSVHFPGELI ACKEASPLVI GLQNGKSNGT ASGIANGSVM NKLFFSSDVA SFLPYTQEVI FLEDGDVAHY SKGALTLYND ATPVSRTSQT VDVSPEGLCK GAYPSFMLKE IYEQPESVSR SMRDRIDFNT REVTIKEMSD GVRTTLLSAR RLMLVACGTS FHSCVAARPI FEELLPNISI TLENAPDLLD REPRIGSDDV CVFVSQSGET ADTLMALQYC KKYEAMIVGL TNVPGSSVLR LSDFALLLNA GVEVGVASTK AYTSQVVVLT LLALFLSKEN CSGNSSHSHG GSQSPIQKRR LEIIDGLAAL PGALSHCLKC TNDVATKLAE ELCDAKAILI LGRGYDYATA LEAALKVKEL TYIHTEGIHC GELKHGPLAL VDEHSTIVAF CPHDKFLGRS KSAIQQVKAR GGRVVAITTE PDAELVSATS RCVEVPAIVD CLQGIVNVVP LQLLAHHLAV RRGLNVDCPR NLAKSVTVQ //