ID C9K0Z0_MOUSE Unreviewed; 883 AA. AC C9K0Z0; DT 24-NOV-2009, integrated into UniProtKB/TrEMBL. DT 24-NOV-2009, sequence version 1. DT 27-SEP-2017, entry version 51. DE SubName: Full=AMPA-selective glutamate receptor 2 flop type {ECO:0000313|EMBL:BAI44626.1}; GN Name=Gria2 {ECO:0000313|MGI:MGI:95809}; GN Synonyms=glur-2 {ECO:0000313|EMBL:BAI44626.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAI44626.1}; RN [1] {ECO:0000313|EMBL:BAI44626.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=DdY {ECO:0000313|EMBL:BAI44626.1}; RC TISSUE=Spinal cord {ECO:0000313|EMBL:BAI44626.1}; RA Nishizawa M., Ito S.; RT "Expression of AMPA receptor subtypes in mouse spinal cord."; RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell CC membrane {ECO:0000256|SAAS:SAAS00582638}. CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel CC (TC 1.A.10.1) family. {ECO:0000256|SAAS:SAAS00586618}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB109210; BAI44626.1; -; mRNA. DR UniGene; Mm.220224; -. DR ProteinModelPortal; C9K0Z0; -. DR PaxDb; C9K0Z0; -. DR PeptideAtlas; C9K0Z0; -. DR PRIDE; C9K0Z0; -. DR MGI; MGI:95809; Gria2. DR eggNOG; KOG1054; Eukaryota. DR eggNOG; ENOG410XPSH; LUCA. DR GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005234; F:extracellular-glutamate-gated ion channel activity; IEA:InterPro. DR GO; GO:0004970; F:ionotropic glutamate receptor activity; IEA:InterPro. DR InterPro; IPR001828; ANF_lig-bd_rcpt. DR InterPro; IPR019594; Glu/Gly-bd. DR InterPro; IPR001508; Iono_rcpt_met. DR InterPro; IPR001320; Iontro_rcpt. DR InterPro; IPR028082; Peripla_BP_I. DR Pfam; PF01094; ANF_receptor; 1. DR Pfam; PF00060; Lig_chan; 1. DR Pfam; PF10613; Lig_chan-Glu_bd; 1. DR PRINTS; PR00177; NMDARECEPTOR. DR SMART; SM00918; Lig_chan-Glu_bd; 1. DR SMART; SM00079; PBPe; 1. DR SUPFAM; SSF53822; SSF53822; 1. PE 2: Evidence at transcript level; KW Cell junction {ECO:0000256|SAAS:SAAS00111850}; KW Cell membrane {ECO:0000256|SAAS:SAAS00618203}; KW Ion channel {ECO:0000256|SAAS:SAAS00586583}; KW Ion transport {ECO:0000256|SAAS:SAAS00586604}; KW Ligand-gated ion channel {ECO:0000256|SAAS:SAAS00586652}; KW Membrane {ECO:0000256|SAAS:SAAS00425055, ECO:0000256|SAM:Phobius}; KW Postsynaptic cell membrane {ECO:0000256|SAAS:SAAS00111890}; KW Receptor {ECO:0000256|SAAS:SAAS00586650, ECO:0000313|EMBL:BAI44626.1}; KW Signal {ECO:0000256|SAM:SignalP}; KW Synapse {ECO:0000256|SAAS:SAAS00111882}; KW Transmembrane {ECO:0000256|SAAS:SAAS00425026, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00425515, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00586666}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 883 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002996617. FT TRANSMEM 542 564 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 625 647 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 815 837 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 415 790 PBPe. {ECO:0000259|SMART:SM00079}. FT DOMAIN 425 490 Lig_chan-Glu_bd. {ECO:0000259|SMART: FT SM00918}. SQ SEQUENCE 883 AA; 98574 MW; 9BBE632C31CB01FF CRC64; MQKIMHISVL LSPVLWGLIF GVSSNSIQIG GLFPRGADQE YSAFRVGMVQ FSTSEFRLTP HIDNLEVANS FAVTNAFCSQ FSRGVYAIFG FYDKKSVNTI TSFCGTLHVS FITPSFPTDG THPFVIQMRP DLKGALLSLI EYYQWDKFAY LYDSDRGLST LQAVLDSAAE KKWQVTAINV GNINNDKKDE TYRSLFQDLE LKKERRVILD CERDKVNDIV DQVITIGKHV KGYHYIIANL GFTDGDLLKI QFGGANVSGF QIVVYDDSLA SKFIERWSTL EGKEYPGAHT ATIKYTSALT YDAVQVMTEA FRNLRKQRIE ISRRGNAGDC LANPAVPWGQ GVEIERALKQ VQVEGLSGNI KFDQNGKRIN YTINIMELKT NGPRKIGYWS EVDKMVVTLT ELPSGNDTSG LENKTVVVTT ILESPYVMMK KNHEMLEGNE RYEGYCVDLA AEIAKHCGFK YKLTIVGDGK YGARDADTKI WNGMVGELVY GKADIAIAPL TITLVREEVI DFSKPFMSLG ISIMIKKPQK SKPGVFSFLD PLAYEIWMCI VFAYIGVSVV LFLVSRFSPY EWHTEEFEDG RETQSSESTN EFGIFNSLWF SLGAFMRQGC DISPRSLSGR IVGGVWWFFT LIIISSYTAN LAAFLTVERM VSPIESAEDL SKQTEIAYGT LDSGSTKEFF RRSKIAVFDK MWTYMRSAEP SVFVRTTAEG VARVRKSKGK YAYLLESTMN EYIEQRKPCD TMKVGGNLDS KGYGIATPKG SSLGNAVNLA VLKLNEQGLL DKLKNKWWYD KGECGSGGGD SKEKTSALSL SNVAGVFYIL VGGLGLAMLV ALIEFCYKSR AEAKRMKVAK NAQNINPSSS QNSQNFATYK EGYNVYGIES VKI //