ID C9JJQ8_HUMAN Unreviewed; 198 AA. AC C9JJQ8; DT 03-NOV-2009, integrated into UniProtKB/TrEMBL. DT 03-NOV-2009, sequence version 1. DT 28-NOV-2012, entry version 23. DE SubName: Full=Tubulin alpha-4A chain; DE Flags: Fragment; GN Name=TUBA4A; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [2] RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- FUNCTION: Tubulin is the major constituent of microtubules. It CC binds two moles of GTP, one at an exchangeable site on the beta CC chain and one at a non-exchangeable site on the alpha-chain (By CC similarity). CC -!- SUBUNIT: Dimer of alpha and beta chains (By similarity). CC -!- SIMILARITY: Belongs to the tubulin family. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC068946; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC114803; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR IPI; IPI00794009; -. DR ProteinModelPortal; C9JJQ8; -. DR SMR; C9JJQ8; 25-198. DR STRING; C9JJQ8; -. DR PRIDE; C9JJQ8; -. DR Ensembl; ENST00000456818; ENSP00000416992; ENSG00000127824. DR HGNC; HGNC:12407; TUBA4A. DR HOGENOM; HOG000165712; -. DR Bgee; C9JJQ8; -. DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW. DR GO; GO:0015630; C:microtubule cytoskeleton; IDA:HPA. DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro. DR GO; GO:0051258; P:protein polymerization; IEA:InterPro. DR Gene3D; 3.40.50.1440; Tubulin_FtsZ; 1. DR InterPro; IPR002452; Alpha_tubulin. DR InterPro; IPR000217; Tubulin. DR InterPro; IPR017975; Tubulin_CS. DR InterPro; IPR003008; Tubulin_FtsZ_GTPase. DR PANTHER; PTHR11588; PTHR11588; 1. DR Pfam; PF00091; Tubulin; 1. DR PRINTS; PR01162; ALPHATUBULIN. DR PRINTS; PR01161; TUBULIN. DR SMART; SM00864; Tubulin; 1. DR SUPFAM; SSF52490; Tubulin_FtsZ; 1. DR PROSITE; PS00227; TUBULIN; 1. PE 3: Inferred from homology; KW Complete proteome; GTP-binding; Microtubule; Nucleotide-binding; KW Reference proteome. FT NON_TER 198 198 SQ SEQUENCE 198 AA; 21678 MW; E311C05987F08A25 CRC64; MAPILPGTRR VTSGASPQVP LPFWRECISV HVGQAGVQMG NACWELYCLE HGIQPDGQMP SDKTIGGGDD SFTTFFCETG AGKHVPRAVF VDLEPTVIDE IRNGPYRQLF HPEQLITGKE DAANNYARGH YTIGKEIIDP VLDRIRKLSD QCTGLQGFLV FHSFGGGTGS GFTSLLMERL SVDYGKKSKL EFSIYPAP //