ID   BTBDJ_HUMAN             Reviewed;         291 AA.
AC   C9JJ37; B4E384; B7ZC36; B7ZC37;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   29-SEP-2021, entry version 82.
DE   RecName: Full=BTB/POZ domain-containing protein 19;
GN   Name=BTBD19;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Uterus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=C9JJ37-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=C9JJ37-2; Sequence=VSP_039226;
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DR   EMBL; AK304611; BAG65396.1; -; mRNA.
DR   EMBL; AL592166; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001130009.1; NM_001136537.1. [C9JJ37-1]
DR   SMR; C9JJ37; -.
DR   STRING; 9606.ENSP00000395461; -.
DR   BioMuta; BTBD19; -.
DR   MassIVE; C9JJ37; -.
DR   PaxDb; C9JJ37; -.
DR   PeptideAtlas; C9JJ37; -.
DR   PRIDE; C9JJ37; -.
DR   ProteomicsDB; 10430; -. [C9JJ37-1]
DR   ProteomicsDB; 10431; -. [C9JJ37-2]
DR   Antibodypedia; 58461; 24 antibodies.
DR   DNASU; 149478; -.
DR   Ensembl; ENST00000439563; ENSP00000410162; ENSG00000222009. [C9JJ37-2]
DR   Ensembl; ENST00000450269; ENSP00000395461; ENSG00000222009. [C9JJ37-1]
DR   GeneID; 149478; -.
DR   KEGG; hsa:149478; -.
DR   UCSC; uc010ole.1; human. [C9JJ37-1]
DR   CTD; 149478; -.
DR   GeneCards; BTBD19; -.
DR   HGNC; HGNC:27145; BTBD19.
DR   HPA; ENSG00000222009; Low tissue specificity.
DR   neXtProt; NX_C9JJ37; -.
DR   OpenTargets; ENSG00000222009; -.
DR   PharmGKB; PA165750488; -.
DR   VEuPathDB; HostDB:ENSG00000222009; -.
DR   eggNOG; KOG4350; Eukaryota.
DR   GeneTree; ENSGT00940000162133; -.
DR   HOGENOM; CLU_077764_0_0_1; -.
DR   InParanoid; C9JJ37; -.
DR   OMA; LCLEFVE; -.
DR   OrthoDB; 940487at2759; -.
DR   PhylomeDB; C9JJ37; -.
DR   TreeFam; TF330633; -.
DR   PathwayCommons; C9JJ37; -.
DR   BioGRID-ORCS; 149478; 6 hits in 221 CRISPR screens.
DR   GenomeRNAi; 149478; -.
DR   Pharos; C9JJ37; Tdark.
DR   PRO; PR:C9JJ37; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; C9JJ37; protein.
DR   Bgee; ENSG00000222009; Expressed in adenohypophysis and 146 other tissues.
DR   ExpressionAtlas; C9JJ37; baseline and differential.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR042846; BTBD19.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR46965; PTHR46965; 1.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..291
FT                   /note="BTB/POZ domain-containing protein 19"
FT                   /id="PRO_0000394239"
FT   DOMAIN          29..98
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          134..234
FT                   /note="BACK"
FT   VAR_SEQ         139..291
FT                   /note="VAVTFGLGQLQERCVAFIEAHSQEALRTRGFLELSAAALLPLLRSDKLCVDE
FT                   AELVRAARSWARVGAAVLERPVAEVAAPVVKELRLALLAPAELSALEEQNRQEPLIPVE
FT                   QIVEAWKCHALRRGDEARGAPCRRRRGTLPREHHRFLDLSFK -> HFWRPRRADQEVR
FT                   RSRPSWLTRWP (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_039226"
SQ   SEQUENCE   291 AA;  32365 MW;  7105A23F9C2FCF62 CRC64;
     MEPLGLVVHG KAEPFSAALR SLVNNPRYSD VCFVVGQERQ EVFAHRCLLA CRCNFFQRLL
     GTEPGPGVPS PVVLSTVPTE AFLAVLEFLY TNSVKLYRHS VLEVLTAAVE YGLEELRELC
     LQFVVKVLDV DLVCEALQVA VTFGLGQLQE RCVAFIEAHS QEALRTRGFL ELSAAALLPL
     LRSDKLCVDE AELVRAARSW ARVGAAVLER PVAEVAAPVV KELRLALLAP AELSALEEQN
     RQEPLIPVEQ IVEAWKCHAL RRGDEARGAP CRRRRGTLPR EHHRFLDLSF K
//