ID C9JG63_HUMAN Unreviewed; 432 AA. AC C9JG63; DT 03-NOV-2009, integrated into UniProtKB/TrEMBL. DT 05-OCT-2016, sequence version 8. DT 24-JUL-2024, entry version 96. DE RecName: Full=Sprouty-related, EVH1 domain-containing protein 2 {ECO:0000256|ARBA:ARBA00039299}; DE Flags: Fragment; GN Name=SPRED2 {ECO:0000313|Ensembl:ENSP00000390595.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000390595.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., RA Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 and RT 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0007829|PubMed:23186163} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=23186163; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [3] {ECO:0000313|Ensembl:ENSP00000390595.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2024) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413}; CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cytoplasmic vesicle, CC secretory vesicle membrane {ECO:0000256|ARBA:ARBA00004360}; Peripheral CC membrane protein {ECO:0000256|ARBA:ARBA00004360}; Cytoplasmic side CC {ECO:0000256|ARBA:ARBA00004360}. Membrane CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side CC {ECO:0000256|ARBA:ARBA00004287}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC012370; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC097503; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR AlphaFoldDB; C9JG63; -. DR SMR; C9JG63; -. DR MassIVE; C9JG63; -. DR PeptideAtlas; C9JG63; -. DR ProteomicsDB; 10068; -. DR Antibodypedia; 30873; 146 antibodies from 30 providers. DR Ensembl; ENST00000452315.5; ENSP00000390595.1; ENSG00000198369.10. DR UCSC; uc061juv.1; human. DR HGNC; HGNC:17722; SPRED2. DR VEuPathDB; HostDB:ENSG00000198369; -. DR GeneTree; ENSGT00940000156841; -. DR ChiTaRS; SPRED2; human. DR Proteomes; UP000005640; Chromosome 2. DR Bgee; ENSG00000198369; Expressed in sural nerve and 181 other cell types or tissues. DR ExpressionAtlas; C9JG63; baseline and differential. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell. DR GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro. DR CDD; cd10574; EVH1_SPRED-like; 1. DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1. DR InterPro; IPR023337; KBD. DR InterPro; IPR011993; PH-like_dom_sf. DR InterPro; IPR041937; SPRE_EVH1. DR InterPro; IPR007875; Sprouty. DR InterPro; IPR000697; WH1/EVH1_dom. DR PANTHER; PTHR11202:SF11; SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN 2; 1. DR PANTHER; PTHR11202; SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER; 1. DR Pfam; PF05210; Sprouty; 1. DR Pfam; PF00568; WH1; 1. DR SMART; SM00461; WH1; 1. DR SUPFAM; SSF50729; PH domain-like; 1. DR PROSITE; PS51488; KBD; 1. DR PROSITE; PS51227; SPR; 1. DR PROSITE; PS50229; WH1; 1. PE 1: Evidence at protein level; KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Proteomics identification {ECO:0007829|PeptideAtlas:C9JG63, KW ECO:0007829|ProteomicsDB:C9JG63}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 20..137 FT /note="WH1" FT /evidence="ECO:0000259|PROSITE:PS50229" FT DOMAIN 216..272 FT /note="KBD" FT /evidence="ECO:0000259|PROSITE:PS51488" FT REGION 142..186 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 290..317 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 160..186 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 432 FT /evidence="ECO:0000313|Ensembl:ENSP00000390595.1" SQ SEQUENCE 432 AA; 49101 MW; A025BE8D8BB5CCBB CRC64; MALCSLISSW ASGFRSDDDQ ERRGDSYIVR VKAVVMTRDD SSGGWFPQEG GGISRVGVCK VMHPEGNGRS GFLIHGERQK DKLVVLECYV RKDLVYTKAN PTFHHWKVDN RKFGLTFQSP ADARAFDRGV RKAIEDLIEG STTSSSTIHN EAELGDDDVF TTATDSSSNS SQKREQPTRT ISSPTSCEHR RIYTLGHLHD SYPTDHYHLD QPMPRPYRQV SFPDDDEEIV RINPREKIWM TGYEDYRHAP VRGKYPDPSE DADSSYVRFA KGEVPKHDYN YPYVDSSDFG LGEDPKGRGG SVIKTQPSRG KSRRRKEDGE RSRCVYCRDM FNHEENRRGH CQDAPDSVRT CIRRVSCMWC ADSMLYHCMS DPEGDYTDPC SCDTSDEKFC LRWMALIALS FLAPCMCCYL PLRACYHCGV MCRCCGGKHK AA //