ID C9JG63_HUMAN Unreviewed; 432 AA. AC C9JG63; DT 03-NOV-2009, integrated into UniProtKB/TrEMBL. DT 05-OCT-2016, sequence version 8. DT 10-FEB-2021, entry version 80. DE SubName: Full=Sprouty-related, EVH1 domain-containing protein 2 {ECO:0000313|Ensembl:ENSP00000390595}; DE Flags: Fragment; GN Name=SPRED2 {ECO:0000313|Ensembl:ENSP00000390595}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000390595, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000390595, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., RA Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 and RT 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0000313|Ensembl:ENSP00000390595} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [3] {ECO:0000213|PubMed:23186163} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=23186163; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC012370; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC097503; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; C9JG63; -. DR PRIDE; C9JG63; -. DR ProteomicsDB; 10068; -. DR Antibodypedia; 30873; 141 antibodies. DR Ensembl; ENST00000452315; ENSP00000390595; ENSG00000198369. DR UCSC; uc061juv.1; human. DR HGNC; HGNC:17722; SPRED2. DR OpenTargets; ENSG00000198369; -. DR VEuPathDB; HostDB:ENSG00000198369.9; -. DR GeneTree; ENSGT00940000156841; -. DR OMA; LRACHWM; -. DR ChiTaRS; SPRED2; human. DR Proteomes; UP000005640; Chromosome 2. DR Bgee; ENSG00000198369; Expressed in forebrain and 220 other tissues. DR ExpressionAtlas; C9JG63; baseline and differential. DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl. DR GO; GO:0030291; F:protein serine/threonine kinase inhibitor activity; IEA:Ensembl. DR GO; GO:0005173; F:stem cell factor receptor binding; IEA:Ensembl. DR GO; GO:0000188; P:inactivation of MAPK activity; IEA:Ensembl. DR GO; GO:0007275; P:multicellular organism development; IEA:InterPro. DR GO; GO:0010719; P:negative regulation of epithelial to mesenchymal transition; IEA:Ensembl. DR GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IEA:Ensembl. DR GO; GO:1902747; P:negative regulation of lens fiber cell differentiation; IEA:Ensembl. DR GO; GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; IEA:Ensembl. DR GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl. DR GO; GO:0043517; P:positive regulation of DNA damage response, signal transduction by p53 class mediator; IEA:Ensembl. DR GO; GO:0090311; P:regulation of protein deacetylation; IEA:Ensembl. DR CDD; cd10574; EVH1_SPRED-like; 1. DR Gene3D; 2.30.29.30; -; 1. DR InterPro; IPR023337; KBD. DR InterPro; IPR011993; PH-like_dom_sf. DR InterPro; IPR041937; SPRE_EVH1. DR InterPro; IPR007875; Sprouty. DR InterPro; IPR000697; WH1/EVH1_dom. DR Pfam; PF05210; Sprouty; 1. DR Pfam; PF00568; WH1; 1. DR SMART; SM00461; WH1; 1. DR PROSITE; PS51488; KBD; 1. DR PROSITE; PS51227; SPR; 1. DR PROSITE; PS50229; WH1; 1. PE 1: Evidence at protein level; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Proteomics identification {ECO:0000213|PeptideAtlas:C9JG63, KW ECO:0000213|ProteomicsDB:C9JG63}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 20..137 FT /note="WH1" FT /evidence="ECO:0000259|PROSITE:PS50229" FT DOMAIN 216..272 FT /note="KBD" FT /evidence="ECO:0000259|PROSITE:PS51488" FT REGION 142..186 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 290..317 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 160..186 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 432 FT /evidence="ECO:0000313|Ensembl:ENSP00000390595" SQ SEQUENCE 432 AA; 49101 MW; A025BE8D8BB5CCBB CRC64; MALCSLISSW ASGFRSDDDQ ERRGDSYIVR VKAVVMTRDD SSGGWFPQEG GGISRVGVCK VMHPEGNGRS GFLIHGERQK DKLVVLECYV RKDLVYTKAN PTFHHWKVDN RKFGLTFQSP ADARAFDRGV RKAIEDLIEG STTSSSTIHN EAELGDDDVF TTATDSSSNS SQKREQPTRT ISSPTSCEHR RIYTLGHLHD SYPTDHYHLD QPMPRPYRQV SFPDDDEEIV RINPREKIWM TGYEDYRHAP VRGKYPDPSE DADSSYVRFA KGEVPKHDYN YPYVDSSDFG LGEDPKGRGG SVIKTQPSRG KSRRRKEDGE RSRCVYCRDM FNHEENRRGH CQDAPDSVRT CIRRVSCMWC ADSMLYHCMS DPEGDYTDPC SCDTSDEKFC LRWMALIALS FLAPCMCCYL PLRACYHCGV MCRCCGGKHK AA //