ID C9JG63_HUMAN Unreviewed; 432 AA. AC C9JG63; DT 03-NOV-2009, integrated into UniProtKB/TrEMBL. DT 05-OCT-2016, sequence version 8. DT 05-DEC-2018, entry version 69. DE SubName: Full=Sprouty-related, EVH1 domain-containing protein 2 {ECO:0000313|Ensembl:ENSP00000390595}; DE Flags: Fragment; GN Name=SPRED2 {ECO:0000313|Ensembl:ENSP00000390595}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000390595, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000390595, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0000313|Ensembl:ENSP00000390595} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. RN [3] {ECO:0000213|PubMed:23186163} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=23186163; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC012370; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC097503; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; C9JG63; -. DR PeptideAtlas; C9JG63; -. DR PRIDE; C9JG63; -. DR Ensembl; ENST00000452315; ENSP00000390595; ENSG00000198369. DR UCSC; uc061juv.1; human. DR EuPathDB; HostDB:ENSG00000198369.9; -. DR HGNC; HGNC:17722; SPRED2. DR OpenTargets; ENSG00000198369; -. DR eggNOG; ENOG410IQ21; Eukaryota. DR eggNOG; ENOG410Y62R; LUCA. DR GeneTree; ENSGT00940000156841; -. DR HOGENOM; HOG000220886; -. DR OMA; DHYHLEQ; -. DR OrthoDB; EOG091G0OE8; -. DR ChiTaRS; SPRED2; human. DR Proteomes; UP000005640; Chromosome 2. DR Bgee; ENSG00000198369; Expressed in 208 organ(s), highest expression level in forebrain. DR ExpressionAtlas; C9JG63; baseline and differential. DR GO; GO:0016020; C:membrane; IEA:InterPro. DR GO; GO:0007275; P:multicellular organism development; IEA:InterPro. DR GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro. DR Gene3D; 2.30.29.30; -; 1. DR InterPro; IPR023337; KBD. DR InterPro; IPR011993; PH-like_dom_sf. DR InterPro; IPR007875; Sprouty. DR InterPro; IPR000697; WH1/EVH1_dom. DR Pfam; PF05210; Sprouty; 1. DR Pfam; PF00568; WH1; 1. DR SMART; SM00461; WH1; 1. DR PROSITE; PS51488; KBD; 1. DR PROSITE; PS51227; SPR; 1. DR PROSITE; PS50229; WH1; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|PeptideAtlas:C9JG63}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 20 137 WH1. {ECO:0000259|PROSITE:PS50229}. FT DOMAIN 216 272 KBD. {ECO:0000259|PROSITE:PS51488}. FT NON_TER 432 432 {ECO:0000313|Ensembl:ENSP00000390595}. SQ SEQUENCE 432 AA; 49101 MW; A025BE8D8BB5CCBB CRC64; MALCSLISSW ASGFRSDDDQ ERRGDSYIVR VKAVVMTRDD SSGGWFPQEG GGISRVGVCK VMHPEGNGRS GFLIHGERQK DKLVVLECYV RKDLVYTKAN PTFHHWKVDN RKFGLTFQSP ADARAFDRGV RKAIEDLIEG STTSSSTIHN EAELGDDDVF TTATDSSSNS SQKREQPTRT ISSPTSCEHR RIYTLGHLHD SYPTDHYHLD QPMPRPYRQV SFPDDDEEIV RINPREKIWM TGYEDYRHAP VRGKYPDPSE DADSSYVRFA KGEVPKHDYN YPYVDSSDFG LGEDPKGRGG SVIKTQPSRG KSRRRKEDGE RSRCVYCRDM FNHEENRRGH CQDAPDSVRT CIRRVSCMWC ADSMLYHCMS DPEGDYTDPC SCDTSDEKFC LRWMALIALS FLAPCMCCYL PLRACYHCGV MCRCCGGKHK AA //