ID C9JG63_HUMAN Unreviewed; 432 AA. AC C9JG63; DT 03-NOV-2009, integrated into UniProtKB/TrEMBL. DT 04-FEB-2015, sequence version 4. DT 04-MAR-2015, entry version 40. DE SubName: Full=Sprouty-related, EVH1 domain-containing protein 2 {ECO:0000313|Ensembl:ENSP00000390595}; DE Flags: Fragment; GN Name=SPRED2 {ECO:0000313|Ensembl:ENSP00000390595}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000390595, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000390595, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0000313|Ensembl:ENSP00000390595} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSP00000390595}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC012370; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC097503; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; C9JG63; -. DR Ensembl; ENST00000452315; ENSP00000390595; ENSG00000198369. DR HGNC; HGNC:17722; SPRED2. DR GeneTree; ENSGT00730000110272; -. DR HOGENOM; HOG000220886; -. DR OMA; DHYHLEQ; -. DR PhylomeDB; C9JG63; -. DR ChiTaRS; SPRED2; human. DR NextBio; 35486390; -. DR Proteomes; UP000005640; Chromosome 2. DR Bgee; C9JG63; -. DR ExpressionAtlas; C9JG63; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IDA:HPA. DR GO; GO:0016020; C:membrane; IEA:InterPro. DR GO; GO:0005654; C:nucleoplasm; IDA:HPA. DR GO; GO:0007275; P:multicellular organismal development; IEA:InterPro. DR GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro. DR Gene3D; 2.30.29.30; -; 1. DR InterPro; IPR023337; KBD. DR InterPro; IPR011993; PH_like_dom. DR InterPro; IPR007875; Sprouty. DR InterPro; IPR000697; WH1/EVH1. DR Pfam; PF05210; Sprouty; 1. DR Pfam; PF00568; WH1; 1. DR SMART; SM00461; WH1; 1. DR PROSITE; PS51488; KBD; 1. DR PROSITE; PS51227; SPR; 1. DR PROSITE; PS50229; WH1; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000256|MaxQB:C9JG63, KW ECO:0000256|PeptideAtlas:C9JG63}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT NON_TER 432 432 {ECO:0000313|Ensembl:ENSP00000390595}. SQ SEQUENCE 432 AA; 49101 MW; A025BE8D8BB5CCBB CRC64; MALCSLISSW ASGFRSDDDQ ERRGDSYIVR VKAVVMTRDD SSGGWFPQEG GGISRVGVCK VMHPEGNGRS GFLIHGERQK DKLVVLECYV RKDLVYTKAN PTFHHWKVDN RKFGLTFQSP ADARAFDRGV RKAIEDLIEG STTSSSTIHN EAELGDDDVF TTATDSSSNS SQKREQPTRT ISSPTSCEHR RIYTLGHLHD SYPTDHYHLD QPMPRPYRQV SFPDDDEEIV RINPREKIWM TGYEDYRHAP VRGKYPDPSE DADSSYVRFA KGEVPKHDYN YPYVDSSDFG LGEDPKGRGG SVIKTQPSRG KSRRRKEDGE RSRCVYCRDM FNHEENRRGH CQDAPDSVRT CIRRVSCMWC ADSMLYHCMS DPEGDYTDPC SCDTSDEKFC LRWMALIALS FLAPCMCCYL PLRACYHCGV MCRCCGGKHK AA //