ID C9J7D9_HUMAN Unreviewed; 192 AA. AC C9J7D9; DT 03-NOV-2009, integrated into UniProtKB/TrEMBL. DT 05-OCT-2016, sequence version 8. DT 02-OCT-2024, entry version 90. DE SubName: Full=Dedicator of cytokinesis 4 {ECO:0000313|Ensembl:ENSP00000406298.1}; DE Flags: Fragment; GN Name=DOCK4 {ECO:0000313|Ensembl:ENSP00000406298.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000406298.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000406298.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=11237011; DOI=10.1038/35057062; RG International Human Genome Sequencing Consortium; RA Lander E.S., Linton L.M., Birren B., Nusbaum C., Zody M.C., Baldwin J., RA Devon K., Dewar K., Doyle M., FitzHugh W., Funke R., Gage D., Harris K., RA Heaford A., Howland J., Kann L., Lehoczky J., LeVine R., McEwan P., RA McKernan K., Meldrim J., Mesirov J.P., Miranda C., Morris W., Naylor J., RA Raymond C., Rosetti M., Santos R., Sheridan A., Sougnez C., RA Stange-Thomann N., Stojanovic N., Subramanian A., Wyman D., Rogers J., RA Sulston J., Ainscough R., Beck S., Bentley D., Burton J., Clee C., RA Carter N., Coulson A., Deadman R., Deloukas P., Dunham A., Dunham I., RA Durbin R., French L., Grafham D., Gregory S., Hubbard T., Humphray S., RA Hunt A., Jones M., Lloyd C., McMurray A., Matthews L., Mercer S., Milne S., RA Mullikin J.C., Mungall A., Plumb R., Ross M., Shownkeen R., Sims S., RA Waterston R.H., Wilson R.K., Hillier L.W., McPherson J.D., Marra M.A., RA Mardis E.R., Fulton L.A., Chinwalla A.T., Pepin K.H., Gish W.R., RA Chissoe S.L., Wendl M.C., Delehaunty K.D., Miner T.L., Delehaunty A., RA Kramer J.B., Cook L.L., Fulton R.S., Johnson D.L., Minx P.J., Clifton S.W., RA Hawkins T., Branscomb E., Predki P., Richardson P., Wenning S., Slezak T., RA Doggett N., Cheng J.F., Olsen A., Lucas S., Elkin C., Uberbacher E., RA Frazier M., Gibbs R.A., Muzny D.M., Scherer S.E., Bouck J.B., RA Sodergren E.J., Worley K.C., Rives C.M., Gorrell J.H., Metzker M.L., RA Naylor S.L., Kucherlapati R.S., Nelson D.L., Weinstock G.M., Sakaki Y., RA Fujiyama A., Hattori M., Yada T., Toyoda A., Itoh T., Kawagoe C., RA Watanabe H., Totoki Y., Taylor T., Weissenbach J., Heilig R., Saurin W., RA Artiguenave F., Brottier P., Bruls T., Pelletier E., Robert C., Wincker P., RA Smith D.R., Doucette-Stamm L., Rubenfield M., Weinstock K., Lee H.M., RA Dubois J., Rosenthal A., Platzer M., Nyakatura G., Taudien S., Rump A., RA Yang H., Yu J., Wang J., Huang G., Gu J., Hood L., Rowen L., Madan A., RA Qin S., Davis R.W., Federspiel N.A., Abola A.P., Proctor M.J., Myers R.M., RA Schmutz J., Dickson M., Grimwood J., Cox D.R., Olson M.V., Kaul R., RA Raymond C., Shimizu N., Kawasaki K., Minoshima S., Evans G.A., RA Athanasiou M., Schultz R., Roe B.A., Chen F., Pan H., Ramser J., RA Lehrach H., Reinhardt R., McCombie W.R., de la Bastide M., Dedhia N., RA Blocker H., Hornischer K., Nordsiek G., Agarwala R., Aravind L., RA Bailey J.A., Bateman A., Batzoglou S., Birney E., Bork P., Brown D.G., RA Burge C.B., Cerutti L., Chen H.C., Church D., Clamp M., Copley R.R., RA Doerks T., Eddy S.R., Eichler E.E., Furey T.S., Galagan J., Gilbert J.G., RA Harmon C., Hayashizaki Y., Haussler D., Hermjakob H., Hokamp K., Jang W., RA Johnson L.S., Jones T.A., Kasif S., Kaspryzk A., Kennedy S., Kent W.J., RA Kitts P., Koonin E.V., Korf I., Kulp D., Lancet D., Lowe T.M., RA McLysaght A., Mikkelsen T., Moran J.V., Mulder N., Pollara V.J., RA Ponting C.P., Schuler G., Schultz J., Slater G., Smit A.F., Stupka E., RA Szustakowski J., Thierry-Mieg D., Thierry-Mieg J., Wagner L., Wallis J., RA Wheeler R., Williams A., Wolf Y.I., Wolfe K.H., Yang S.P., Yeh R.F., RA Collins F., Guyer M.S., Peterson J., Felsenfeld A., Wetterstrand K.A., RA Patrinos A., Morgan M.J., de Jong P., Catanese J.J., Osoegawa K., RA Shizuya H., Choi S., Chen Y.J.; RT "Initial sequencing and analysis of the human genome."; RL Nature 409:860-921(2001). RN [2] {ECO:0000313|Ensembl:ENSP00000406298.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12853948; DOI=10.1038/nature01782; RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H., RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., RA Rohlfing T., Rock S.M., Tin-Wollam A.M., Abbott A., Minx P., Maupin R., RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., RA Woessner J.P., Wendl M.C., Yang S.P., Schultz B.R., Wallis J.W., Spieth J., RA Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., RA Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., RA Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., RA Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., RA Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., RA Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., RA Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., RA Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.; RT "The DNA sequence of human chromosome 7."; RL Nature 424:157-164(2003). RN [3] {ECO:0000313|Ensembl:ENSP00000406298.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15496913; DOI=10.1038/nature03001; RG International Human Genome Sequencing Consortium; RT "Finishing the euchromatic sequence of the human genome."; RL Nature 431:931-945(2004). RN [4] {ECO:0000313|Ensembl:ENSP00000406298.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2024) to UniProtKB. CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE- CC ProRule:PRU00984}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC003077; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC003080; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC005047; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF458551; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF458553; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF458554; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF510967; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR AlphaFoldDB; C9J7D9; -. DR SMR; C9J7D9; -. DR MassIVE; C9J7D9; -. DR PeptideAtlas; C9J7D9; -. DR ProteomicsDB; 8898; -. DR Antibodypedia; 31488; 160 antibodies from 23 providers. DR Ensembl; ENST00000437129.5; ENSP00000406298.1; ENSG00000128512.24. DR UCSC; uc064hcw.1; human. DR HGNC; HGNC:19192; DOCK4. DR VEuPathDB; HostDB:ENSG00000128512; -. DR GeneTree; ENSGT00940000155659; -. DR HOGENOM; CLU_101221_0_0_1; -. DR ChiTaRS; DOCK4; human. DR Proteomes; UP000005640; Chromosome 7. DR Bgee; ENSG00000128512; Expressed in endothelial cell and 199 other cell types or tissues. DR ExpressionAtlas; C9J7D9; baseline and differential. DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. DR GO; GO:0007264; P:small GTPase-mediated signal transduction; IEA:InterPro. DR Gene3D; 1.25.40.410; -; 1. DR InterPro; IPR026791; DOCK. DR InterPro; IPR043161; DOCK_C_lobe_A. DR InterPro; IPR027357; DOCKER_dom. DR InterPro; IPR046769; DOCKER_Lobe_A. DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1. DR PANTHER; PTHR45653:SF7; DEDICATOR OF CYTOKINESIS PROTEIN 4; 1. DR Pfam; PF06920; DHR-2_Lobe_A; 1. DR PROSITE; PS51651; DOCKER; 1. PE 1: Evidence at protein level; KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658}; KW Proteomics identification {ECO:0007829|PeptideAtlas:C9J7D9, KW ECO:0007829|ProteomicsDB:C9J7D9}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 64..192 FT /note="DOCKER" FT /evidence="ECO:0000259|PROSITE:PS51651" FT NON_TER 192 FT /evidence="ECO:0000313|Ensembl:ENSP00000406298.1" SQ SEQUENCE 192 AA; 23444 MW; 2729B02DA28F6FFD CRC64; MKMHSTESLL KKIERETWRE SGVSLIATVT RLMERLLDYR DCMKMGEVDG KKIGCTVSLL NFYKTELNKE EMYIRYIHKL YDLHLKAQNF TEAAYTLLLY DELLEWSDRP LREFLTYPMQ TEWQRKEHLH LTIIQNFDRG KCWENGIILC RKIAEQYESY YDYRNLSKMR MMEASLYDKI MDQQRLEPEF FR //