ID C9J7D9_HUMAN Unreviewed; 192 AA. AC C9J7D9; DT 03-NOV-2009, integrated into UniProtKB/TrEMBL. DT 05-OCT-2016, sequence version 8. DT 07-APR-2021, entry version 73. DE SubName: Full=Dedicator of cytokinesis protein 4 {ECO:0000313|Ensembl:ENSP00000406298}; DE Flags: Fragment; GN Name=DOCK4 {ECO:0000313|Ensembl:ENSP00000406298}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000406298, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000406298, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12853948; DOI=10.1038/nature01782; RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H., RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., RA Wilson R.K.; RT "The DNA sequence of human chromosome 7."; RL Nature 424:157-164(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000406298} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE- CC ProRule:PRU00984}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC003077; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC003080; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC005047; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF458551; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF458553; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF458554; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF510967; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; C9J7D9; -. DR PRIDE; C9J7D9; -. DR ProteomicsDB; 8898; -. DR Antibodypedia; 31488; 130 antibodies. DR Ensembl; ENST00000437129; ENSP00000406298; ENSG00000128512. DR UCSC; uc064hcw.1; human. DR HGNC; HGNC:19192; DOCK4. DR OpenTargets; ENSG00000128512; -. DR VEuPathDB; HostDB:ENSG00000128512.19; -. DR GeneTree; ENSGT00940000155659; -. DR HOGENOM; CLU_101221_0_0_1; -. DR ChiTaRS; DOCK4; human. DR Proteomes; UP000005640; Chromosome 7. DR Bgee; ENSG00000128512; Expressed in endothelial cell and 230 other tissues. DR ExpressionAtlas; C9J7D9; baseline and differential. DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro. DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro. DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. DR Gene3D; 1.25.40.410; -; 1. DR InterPro; IPR027357; DHR-2. DR InterPro; IPR026791; DOCK. DR InterPro; IPR037014; DOCK4. DR InterPro; IPR010703; DOCK_C. DR InterPro; IPR043161; DOCK_C_lobe_A. DR PANTHER; PTHR45653; PTHR45653; 1. DR PANTHER; PTHR45653:SF7; PTHR45653:SF7; 1. DR Pfam; PF06920; DHR-2; 1. DR PROSITE; PS51651; DHR_2; 1. PE 1: Evidence at protein level; KW Proteomics identification {ECO:0007829|MaxQB:C9J7D9, KW ECO:0007829|PeptideAtlas:C9J7D9}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 64..192 FT /note="DOCKER" FT /evidence="ECO:0000259|PROSITE:PS51651" FT NON_TER 192 FT /evidence="ECO:0000313|Ensembl:ENSP00000406298" SQ SEQUENCE 192 AA; 23444 MW; 2729B02DA28F6FFD CRC64; MKMHSTESLL KKIERETWRE SGVSLIATVT RLMERLLDYR DCMKMGEVDG KKIGCTVSLL NFYKTELNKE EMYIRYIHKL YDLHLKAQNF TEAAYTLLLY DELLEWSDRP LREFLTYPMQ TEWQRKEHLH LTIIQNFDRG KCWENGIILC RKIAEQYESY YDYRNLSKMR MMEASLYDKI MDQQRLEPEF FR //