ID C9J7D9_HUMAN Unreviewed; 192 AA. AC C9J7D9; DT 03-NOV-2009, integrated into UniProtKB/TrEMBL. DT 05-OCT-2016, sequence version 8. DT 28-MAR-2018, entry version 60. DE SubName: Full=Dedicator of cytokinesis protein 4 {ECO:0000313|Ensembl:ENSP00000406298}; DE Flags: Fragment; GN Name=DOCK4 {ECO:0000313|Ensembl:ENSP00000406298}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000406298, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12853948; DOI=10.1038/nature01782; RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., RA Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., RA Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., RA Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., RA Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., RA Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., RA Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., RA Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., RA Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., RA Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., RA Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., RA Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., RA Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., RA Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., RA Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., RA Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., RA Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., RA Waterston R.H., Wilson R.K.; RT "The DNA sequence of human chromosome 7."; RL Nature 424:157-164(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000406298} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [3] {ECO:0000313|Ensembl:ENSP00000406298} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE- CC ProRule:PRU00984}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC003077; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC003080; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC005047; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF458551; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF458553; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF458554; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF510967; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; C9J7D9; -. DR PeptideAtlas; C9J7D9; -. DR PRIDE; C9J7D9; -. DR Ensembl; ENST00000437129; ENSP00000406298; ENSG00000128512. DR UCSC; uc064hcw.1; human. DR EuPathDB; HostDB:ENSG00000128512.19; -. DR HGNC; HGNC:19192; DOCK4. DR OpenTargets; ENSG00000128512; -. DR eggNOG; KOG1998; Eukaryota. DR eggNOG; ENOG410XQH7; LUCA. DR GeneTree; ENSGT00610000085806; -. DR ChiTaRS; DOCK4; human. DR Proteomes; UP000005640; Chromosome 7. DR Bgee; ENSG00000128512; -. DR ExpressionAtlas; C9J7D9; baseline and differential. DR GO; GO:0005622; C:intracellular; IEA:GOC. DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro. DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro. DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. DR InterPro; IPR027357; DHR-2. DR InterPro; IPR026791; DOCK. DR InterPro; IPR037014; DOCK4. DR InterPro; IPR010703; DOCK_C. DR PANTHER; PTHR23317; PTHR23317; 1. DR PANTHER; PTHR23317:SF75; PTHR23317:SF75; 1. DR Pfam; PF06920; DHR-2; 1. DR PROSITE; PS51651; DHR_2; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|MaxQB:C9J7D9, KW ECO:0000213|PeptideAtlas:C9J7D9}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 64 192 DHR-2. {ECO:0000259|PROSITE:PS51651}. FT NON_TER 192 192 {ECO:0000313|Ensembl:ENSP00000406298}. SQ SEQUENCE 192 AA; 23444 MW; 2729B02DA28F6FFD CRC64; MKMHSTESLL KKIERETWRE SGVSLIATVT RLMERLLDYR DCMKMGEVDG KKIGCTVSLL NFYKTELNKE EMYIRYIHKL YDLHLKAQNF TEAAYTLLLY DELLEWSDRP LREFLTYPMQ TEWQRKEHLH LTIIQNFDRG KCWENGIILC RKIAEQYESY YDYRNLSKMR MMEASLYDKI MDQQRLEPEF FR //