ID C9D7C6_BOMMO Unreviewed; 2038 AA. AC C9D7C6; DT 03-NOV-2009, integrated into UniProtKB/TrEMBL. DT 03-NOV-2009, sequence version 1. DT 19-JAN-2022, entry version 60. DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132}; GN Name=PARA {ECO:0000313|EMBL:ACV87001.1}; OS Bombyx mori (Silk moth). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea; OC Bombycidae; Bombycinae; Bombyx. OX NCBI_TaxID=7091 {ECO:0000313|EMBL:ACV87001.1}; RN [1] {ECO:0000313|EMBL:ACV87001.1} RP NUCLEOTIDE SEQUENCE. RA Wu X., Qiao M., Jin Y.; RT "Coding region for PARA."; RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of CC excitable membranes. Assuming opened or closed conformations in CC response to the voltage difference across the membrane, the protein CC forms a sodium-selective channel through which Na(+) ions may pass in CC accordance with their electrochemical gradient. CC {ECO:0000256|RuleBase:RU361132}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651, CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}. CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family. CC {ECO:0000256|RuleBase:RU361132}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448, CC ECO:0000256|RuleBase:RU361132}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GQ202023; ACV87001.1; -; mRNA. DR OMA; EDWARKE; -. DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW. DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro. DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW. DR CDD; cd13433; Na_channel_gate; 1. DR Gene3D; 1.20.120.350; -; 4. DR InterPro; IPR002048; EF_hand_dom. DR InterPro; IPR005821; Ion_trans_dom. DR InterPro; IPR001696; Na_channel_asu. DR InterPro; IPR044564; Na_chnl_inactivation_gate. DR InterPro; IPR010526; Na_trans_assoc. DR InterPro; IPR024583; Na_trans_cytopl. DR InterPro; IPR043203; VGCC_Ca_Na. DR InterPro; IPR027359; Volt_channel_dom_sf. DR PANTHER; PTHR10037; PTHR10037; 1. DR Pfam; PF00520; Ion_trans; 4. DR Pfam; PF06512; Na_trans_assoc; 1. DR Pfam; PF11933; Na_trans_cytopl; 1. DR PRINTS; PR00170; NACHANNEL. DR PROSITE; PS50222; EF_HAND_2; 1. PE 2: Evidence at transcript level; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU361132}; KW Ion transport {ECO:0000256|ARBA:ARBA00023065, KW ECO:0000256|RuleBase:RU361132}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132}; KW Sodium channel {ECO:0000256|ARBA:ARBA00022461, KW ECO:0000256|RuleBase:RU361132}; KW Sodium transport {ECO:0000256|ARBA:ARBA00023201, KW ECO:0000256|RuleBase:RU361132}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU361132}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU361132}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132}; KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882, KW ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 133..159 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361132" FT TRANSMEM 171..192 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361132" FT TRANSMEM 204..226 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361132" FT TRANSMEM 232..253 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361132" FT TRANSMEM 262..282 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361132" FT TRANSMEM 392..414 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361132" FT TRANSMEM 799..822 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361132" FT TRANSMEM 843..860 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361132" FT TRANSMEM 872..896 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361132" FT TRANSMEM 927..949 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361132" FT TRANSMEM 969..986 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361132" FT TRANSMEM 1007..1028 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361132" FT TRANSMEM 1287..1306 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361132" FT TRANSMEM 1327..1346 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361132" FT TRANSMEM 1358..1381 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361132" FT TRANSMEM 1402..1433 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361132" FT TRANSMEM 1520..1546 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361132" FT TRANSMEM 1609..1627 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361132" FT TRANSMEM 1639..1658 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361132" FT TRANSMEM 1670..1689 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361132" FT TRANSMEM 1733..1756 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361132" FT TRANSMEM 1826..1846 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU361132" FT DOMAIN 1863..1898 FT /note="EF-hand" FT /evidence="ECO:0000259|PROSITE:PS50222" FT REGION 36..69 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 429..578 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 640..686 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1162..1209 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2019..2038 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 36..51 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 429..460 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 478..495 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 510..526 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 662..677 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1173..1209 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 2038 AA; 230985 MW; C08FC69A66AE88AE CRC64; MSEDLDSISE EERSLFRPFT RESLAAIEAR IAEEHAKQKE LEKKRAEGEV RYDDEDEDEG PQPDATLEQG LPLPVRMQGS FPLELASTPL EDIDPFYHNQ TTFVVISKGK DIFRFSATNA LWILDPFNPI RRVAIYILVH PLFSLFIITT ILVNCILMIM PTTPTVESTE VIFTGIYTFE SAVKVMARGF ILQPFTYLRD AWNWLDFVVI ALAYVTMGID LGNLAALRTF RVLRALNTVA IVPGLKTIVG AVIESVKNLR DVIILTMFSL SVFALMGLQI YMGVLTQKCV KVFPEDGSWG NLTDENWERF CQNETNWYGE GGDYPLCGNS SGAGQCEPGY VCLQGFGPNP NYGYTSFDTF GWAFLSAFRL MTQDYWENLY QLVLRSAGSW HVLFFVVIIF LGSFYLVNLI LAIVAMSYDE LQKKAEEEEQ AEEEALREAE QKAAARADKQ EAREAHAREQ AAAAEAAAYA EAHPAKSPSD FSCQSYELFV NQERGNQDDN TRERMSLRSD PFQDSVSTQP AHKPTATDTH DSARRPRKVS MASLSLPGSP FNLRRGSRGS HQMALRPNGR PRYPPGGDRK PLVLSTYLDA QEHLPYADDS NAVTPMSEEN GAIIIPVYYA NLGSRHSSYT SHQSRLSYTS HGDLLGGGKA QTKEARLRGR SASRNHSVTS QPHAYPLPRQ DSSLASRPLR EYEVSTTECT DEAGKVLKPS SDNPFIESSQ QPNVVDMRDV MVLNEIIEQA GRQSRASEQN VSVYYFPTAE DDEDGPTFKE KLLDCLMKGI DFFCVWDCCW LWLEFQKYVA LLVFDPFVEL FITLCIVVNT LFMALDHHNM DKDMDKALKS GNYFFTATFG IEATLKLIAM SPKYYFQEGW NIFDFIIVAL SLLELGLEGV QGLSVLRSFR LLRVFKLAKS WPTLNLLISI MGRTMGALGN LTFVLCIIIF IFAVMGMQLF GKNYVDYVDR FPDGDLPRWN FTDFMHSFMI VFRVLCGEWI ESMWDCMLVG DVSCIPFFLA TVVIGNLVVL NLFLALLLSN FGSSSLSTPT ADQDTNKIAE AFNRISRFID WIKRNVADFL KLLKNKLTNQ IAIHAPERVD NELELGTDLD DAVLYKDKKL KDQVEVAIGD GMEFTIPGDN KYKKGKILMN NINAITDNHR DNRLDCELNH HGYPIQDDDT ISQKSYGSHK IRSFKDESHK GSADTIDGEE KKDASKEELG LEEELIEEDE EGKLDGTLGK TDIKVGADED VVDDTPADCC PEQCYQKFPF LAGDDDSPFW QGWGTLRLKT FKLIENTYFE TAVITMILLS SLALALEDVH LPHRPILQDI LYYMDRIFTV IFFIEMLIKW LALGFQKYFT NAWCWLDFII VMVSLINFVA ALCGAGGIQA FKTMRTLRAL RPLRAMSRMQ GMRVVVNALV QAIPSIFNVL LVCLIFWLIF AIMGVQLFAG KYFKCVDMNH TTLSHEIIPD KNACTLENYT WENSPMNFDH VGKAYLCLFQ VATFKGWIQI MNDAIDSREV GRQPIRETNI YMYLYFVFFI IFGSFFTLNL FIGVIIDNFN EQKKKAGGSL EMFMTEDQKK YYNAMKKMGS KKPLKAIPRP RWRPQAIVFE IVTDKKFDMI IMLFIGLNML TMTLDHYQQS ETFSAVLDYL NMIFIVIFSS ECLLKIFALR YHYFVEPWNL FDFVVVMFSI LSLVLSDIIE KYFVSPTLLR VVRVAKVGRV LRLVKGAKGI RTLLFALAMS LPALFNICLL LFLVMFIFAI FGMSFFMHVK DKGGLDDVYN FKTFVQSMIL LFQMSTSAGW DGVLDGIINE EECDLPDNER GSPGNCGSAT IGITYLLSYL VISFLIVINM YIAVILENYS QATEDVQEGL TDDDYDMYYE IWQRFDPDGS QYIRYDQLSD SLDVLEPPLQ IHKPNKYKII SMDIPICRGD MMFCVDILDA LTKDFFARKG NPIEETGDLE VGRPEEAGYE PVSSTLWRQR EEYCARLIQH AWRRHRRAHE EPEVGGGAEG AATAVLLDAV TPNGHRVVLQ GGGAAPRPPE PAPPPASV //