ID C9D7C6_BOMMO Unreviewed; 2038 AA. AC C9D7C6; DT 03-NOV-2009, integrated into UniProtKB/TrEMBL. DT 03-NOV-2009, sequence version 1. DT 20-DEC-2017, entry version 42. DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132}; GN Name=PARA {ECO:0000313|EMBL:ACV87001.1}; OS Bombyx mori (Silk moth). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Lepidoptera; Glossata; Ditrysia; OC Bombycoidea; Bombycidae; Bombycinae; Bombyx. OX NCBI_TaxID=7091 {ECO:0000313|EMBL:ACV87001.1}; RN [1] {ECO:0000313|EMBL:ACV87001.1} RP NUCLEOTIDE SEQUENCE. RA Wu X., Qiao M., Jin Y.; RT "Coding region for PARA."; RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability CC of excitable membranes. {ECO:0000256|RuleBase:RU361132}. CC -!- SUBCELLULAR LOCATION: Cell membrane CC {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU361132}. CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family. CC {ECO:0000256|RuleBase:RU361132}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448, CC ECO:0000256|RuleBase:RU361132}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GQ202023; ACV87001.1; -; mRNA. DR UniGene; Bmo.10043; -. DR eggNOG; KOG2301; Eukaryota. DR eggNOG; COG1226; LUCA. DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro. DR InterPro; IPR002048; EF_hand_dom. DR InterPro; IPR005821; Ion_trans_dom. DR InterPro; IPR001696; Na_channel_asu. DR InterPro; IPR010526; Na_trans_assoc. DR InterPro; IPR024583; Na_trans_cytopl. DR Pfam; PF00520; Ion_trans; 4. DR Pfam; PF06512; Na_trans_assoc; 1. DR Pfam; PF11933; Na_trans_cytopl; 1. DR PRINTS; PR00170; NACHANNEL. DR PROSITE; PS50222; EF_HAND_2; 1. PE 2: Evidence at transcript level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Ion channel {ECO:0000256|RuleBase:RU361132}; KW Ion transport {ECO:0000256|RuleBase:RU361132}; KW Membrane {ECO:0000256|RuleBase:RU361132}; KW Sodium {ECO:0000256|RuleBase:RU361132}; KW Sodium channel {ECO:0000256|RuleBase:RU361132}; KW Sodium transport {ECO:0000256|RuleBase:RU361132}; KW Transmembrane {ECO:0000256|RuleBase:RU361132}; KW Transmembrane helix {ECO:0000256|RuleBase:RU361132}; KW Transport {ECO:0000256|RuleBase:RU361132}; KW Voltage-gated channel {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 133 159 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 171 192 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 204 226 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 232 253 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 262 282 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 392 414 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 799 822 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 843 860 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 872 896 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 927 949 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 969 986 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 1007 1028 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 1287 1306 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 1327 1346 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 1358 1381 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 1402 1433 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 1520 1546 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 1609 1627 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 1639 1658 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 1670 1689 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 1733 1756 Helical. {ECO:0000256|RuleBase:RU361132}. FT TRANSMEM 1826 1846 Helical. {ECO:0000256|RuleBase:RU361132}. FT DOMAIN 1863 1898 EF-hand. {ECO:0000259|PROSITE:PS50222}. FT COILED 24 49 {ECO:0000256|SAM:Coils}. FT COILED 411 467 {ECO:0000256|SAM:Coils}. FT COILED 1201 1221 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 2038 AA; 230985 MW; C08FC69A66AE88AE CRC64; MSEDLDSISE EERSLFRPFT RESLAAIEAR IAEEHAKQKE LEKKRAEGEV RYDDEDEDEG PQPDATLEQG LPLPVRMQGS FPLELASTPL EDIDPFYHNQ TTFVVISKGK DIFRFSATNA LWILDPFNPI RRVAIYILVH PLFSLFIITT ILVNCILMIM PTTPTVESTE VIFTGIYTFE SAVKVMARGF ILQPFTYLRD AWNWLDFVVI ALAYVTMGID LGNLAALRTF RVLRALNTVA IVPGLKTIVG AVIESVKNLR DVIILTMFSL SVFALMGLQI YMGVLTQKCV KVFPEDGSWG NLTDENWERF CQNETNWYGE GGDYPLCGNS SGAGQCEPGY VCLQGFGPNP NYGYTSFDTF GWAFLSAFRL MTQDYWENLY QLVLRSAGSW HVLFFVVIIF LGSFYLVNLI LAIVAMSYDE LQKKAEEEEQ AEEEALREAE QKAAARADKQ EAREAHAREQ AAAAEAAAYA EAHPAKSPSD FSCQSYELFV NQERGNQDDN TRERMSLRSD PFQDSVSTQP AHKPTATDTH DSARRPRKVS MASLSLPGSP FNLRRGSRGS HQMALRPNGR PRYPPGGDRK PLVLSTYLDA QEHLPYADDS NAVTPMSEEN GAIIIPVYYA NLGSRHSSYT SHQSRLSYTS HGDLLGGGKA QTKEARLRGR SASRNHSVTS QPHAYPLPRQ DSSLASRPLR EYEVSTTECT DEAGKVLKPS SDNPFIESSQ QPNVVDMRDV MVLNEIIEQA GRQSRASEQN VSVYYFPTAE DDEDGPTFKE KLLDCLMKGI DFFCVWDCCW LWLEFQKYVA LLVFDPFVEL FITLCIVVNT LFMALDHHNM DKDMDKALKS GNYFFTATFG IEATLKLIAM SPKYYFQEGW NIFDFIIVAL SLLELGLEGV QGLSVLRSFR LLRVFKLAKS WPTLNLLISI MGRTMGALGN LTFVLCIIIF IFAVMGMQLF GKNYVDYVDR FPDGDLPRWN FTDFMHSFMI VFRVLCGEWI ESMWDCMLVG DVSCIPFFLA TVVIGNLVVL NLFLALLLSN FGSSSLSTPT ADQDTNKIAE AFNRISRFID WIKRNVADFL KLLKNKLTNQ IAIHAPERVD NELELGTDLD DAVLYKDKKL KDQVEVAIGD GMEFTIPGDN KYKKGKILMN NINAITDNHR DNRLDCELNH HGYPIQDDDT ISQKSYGSHK IRSFKDESHK GSADTIDGEE KKDASKEELG LEEELIEEDE EGKLDGTLGK TDIKVGADED VVDDTPADCC PEQCYQKFPF LAGDDDSPFW QGWGTLRLKT FKLIENTYFE TAVITMILLS SLALALEDVH LPHRPILQDI LYYMDRIFTV IFFIEMLIKW LALGFQKYFT NAWCWLDFII VMVSLINFVA ALCGAGGIQA FKTMRTLRAL RPLRAMSRMQ GMRVVVNALV QAIPSIFNVL LVCLIFWLIF AIMGVQLFAG KYFKCVDMNH TTLSHEIIPD KNACTLENYT WENSPMNFDH VGKAYLCLFQ VATFKGWIQI MNDAIDSREV GRQPIRETNI YMYLYFVFFI IFGSFFTLNL FIGVIIDNFN EQKKKAGGSL EMFMTEDQKK YYNAMKKMGS KKPLKAIPRP RWRPQAIVFE IVTDKKFDMI IMLFIGLNML TMTLDHYQQS ETFSAVLDYL NMIFIVIFSS ECLLKIFALR YHYFVEPWNL FDFVVVMFSI LSLVLSDIIE KYFVSPTLLR VVRVAKVGRV LRLVKGAKGI RTLLFALAMS LPALFNICLL LFLVMFIFAI FGMSFFMHVK DKGGLDDVYN FKTFVQSMIL LFQMSTSAGW DGVLDGIINE EECDLPDNER GSPGNCGSAT IGITYLLSYL VISFLIVINM YIAVILENYS QATEDVQEGL TDDDYDMYYE IWQRFDPDGS QYIRYDQLSD SLDVLEPPLQ IHKPNKYKII SMDIPICRGD MMFCVDILDA LTKDFFARKG NPIEETGDLE VGRPEEAGYE PVSSTLWRQR EEYCARLIQH AWRRHRRAHE EPEVGGGAEG AATAVLLDAV TPNGHRVVLQ GGGAAPRPPE PAPPPASV //