ID C8CHF4_HUMAN Unreviewed; 181 AA. AC C8CHF4; DT 13-OCT-2009, integrated into UniProtKB/TrEMBL. DT 13-OCT-2009, sequence version 1. DT 24-JUL-2024, entry version 48. DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:ACU87544.1}; DE Flags: Fragment; GN Name=HLA-Cw {ECO:0000313|EMBL:ACU87544.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ACU87544.1}; RN [1] {ECO:0000313|EMBL:ACU87544.1} RP NUCLEOTIDE SEQUENCE. RA Yu M., Caparelli E., Czech J., Hartman K., Silva M., James H.E., RA Jennings L.; RT "A novel HLA-C*01 allele identified by PCR-SBT in an donor for a stem cell RT transplantation recipient."; RL Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GQ402147; ACU87544.1; -; Genomic_DNA. DR AlphaFoldDB; C8CHF4; -. DR SMR; C8CHF4; -. DR ChiTaRS; HLA-B; human. DR GO; GO:0009897; C:external side of plasma membrane; IEA:TreeGrafter. DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter. DR GO; GO:0042605; F:peptide antigen binding; IEA:TreeGrafter. DR GO; GO:0005102; F:signaling receptor binding; IEA:TreeGrafter. DR GO; GO:0002486; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; IEA:TreeGrafter. DR GO; GO:0002476; P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib; IEA:TreeGrafter. DR GO; GO:0006955; P:immune response; IEA:TreeGrafter. DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IEA:TreeGrafter. DR Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1. DR InterPro; IPR050208; MHC_class-I_related. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR PANTHER; PTHR16675:SF252; HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, C ALPHA CHAIN; 1. DR PANTHER; PTHR16675; MHC CLASS I-RELATED; 1. DR Pfam; PF00129; MHC_I; 1. DR PRINTS; PR01638; MHCCLASSI. DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1. PE 3: Inferred from homology; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Signal {ECO:0000256|ARBA:ARBA00022729}. FT DOMAIN 1..178 FT /note="MHC class I-like antigen recognition-like" FT /evidence="ECO:0000259|Pfam:PF00129" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:ACU87544.1" FT NON_TER 181 FT /evidence="ECO:0000313|EMBL:ACU87544.1" SQ SEQUENCE 181 AA; 21175 MW; F81B205A3CBC0564 CRC64; SHSMKYFFTS VSRPGRGEPR FISVGYVDDT QFVRFDSDAA SPRGEPRAPW VEQEGPEYWD RETQKYKRQA QTDRVSLRNL RGYYNQSEAG SHTLQWMCGC DLGPDGRLLR GYDQYAYYGK DYIALNEDLR SWTAADTAAQ ITQRKWEAAR EAEQRRAYLE GTCVEWLRRY LENGKETLQR A //