ID C7DY60_BARHN Unreviewed; 318 AA. AC C7DY60; A0A0H3M017; DT 25-JAN-2012, integrated into UniProtKB/TrEMBL. DT 25-JAN-2012, sequence version 1. DT 29-SEP-2021, entry version 66. DE RecName: Full=Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha {ECO:0000256|HAMAP-Rule:MF_00823}; DE Short=ACCase subunit alpha {ECO:0000256|HAMAP-Rule:MF_00823}; DE Short=Acetyl-CoA carboxylase carboxyltransferase subunit alpha {ECO:0000256|HAMAP-Rule:MF_00823}; DE EC=2.1.3.15 {ECO:0000256|HAMAP-Rule:MF_00823}; GN Name=accA {ECO:0000256|HAMAP-Rule:MF_00823, GN ECO:0000313|EMBL:ACT33034.1}; GN ORFNames=BH623125_06830 {ECO:0000313|EMBL:GFF02249.1}, BH80429_14760 GN {ECO:0000313|EMBL:GFF04655.1}, BM1374165_01689 GN {ECO:0000313|EMBL:CDO47661.1}; OS Bartonella henselae (Rochalimaea henselae). OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales; OC Bartonellaceae; Bartonella. OX NCBI_TaxID=38323 {ECO:0000313|EMBL:ACT33034.1}; RN [1] {ECO:0000313|EMBL:ACT33036.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=JK40 {ECO:0000313|EMBL:ACT33036.1}; RA Hsu Y.-M., Chan Y.-J., Chang C.-C.; RT "Acetyl-CoA carboxylase carboxyltransferase subunit alpha gene of RT Bartonella henselae JK40 strain."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ACT33035.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=JK47 {ECO:0000313|EMBL:ACT33035.1}; RA Hsu Y.-M., Chan Y.-J., Chang C.-C.; RT "Acetyl-CoA carboxylase carboxyltransferase subunit alpha gene of RT Bartonella henselae JK47 strain."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:ACT33034.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=U4 {ECO:0000313|EMBL:ACT33034.1}; RA Hsu Y.-M., Chan Y.-J., Chang C.-C.; RT "Acetyl-CoA carboxylase carboxyltransferase subunit alpha gene of RT Bartonella henselae U4 strain."; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Proteomes:UP000019801} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BM1374165 {ECO:0000313|Proteomes:UP000019801}; RA Raoult D.; RT "Genome sequencing of Bartonella spp. isolated from human blood."; RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:CDO47661.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BM1374165 {ECO:0000313|EMBL:CDO47661.1}; RA GENOMES U.; RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:CDO47661.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BM1374165 {ECO:0000313|EMBL:CDO47661.1}; RA Raoult D.; RT "Genome sequencing of Bartonella spp. isolated from human blood."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:GFF02249.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=623-125 {ECO:0000313|EMBL:GFF02249.1}, and 804-29 RC {ECO:0000313|EMBL:GFF04655.1}; RA Tsukamoto K., Shinzawa N., Kawai A., Suzuki M., Kidoya H., Takakura N., RA Yamaguchi H., Kameyama T., Inagaki H., Kurahashi H., Horiguchi Y., Doi Y.; RT "The Bartonella autotransporter BafA activates the host VEGF pathway to RT drive angiogenesis."; RL Nat. Commun. 11:0-3571(2020). RN [8] {ECO:0000313|Proteomes:UP000503821, ECO:0000313|Proteomes:UP000503841} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=623-125 {ECO:0000313|Proteomes:UP000503841}, and 804-29 RC {ECO:0000313|Proteomes:UP000503821}; RA Tsukamoto K., Shinzawa N., Kawai A., Suzuki M., Horiguchi Y., Kidoya H., RA Takakura N., Kameyama T., Inagaki H., Kurahashi H., Doi Y.; RT "Bartonella autotransporter BafA induces angiogenesis via VEGFR2-ERK RT signaling."; RL Submitted (JAN-2020) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Component of the acetyl coenzyme A carboxylase (ACC) complex. CC First, biotin carboxylase catalyzes the carboxylation of biotin on its CC carrier protein (BCCP) and then the CO(2) group is transferred by the CC carboxyltransferase to acetyl-CoA to form malonyl-CoA. CC {ECO:0000256|HAMAP-Rule:MF_00823}. CC -!- CATALYTIC ACTIVITY: CC Reaction=acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl- CC CoA + N(6)-biotinyl-L-lysyl-[protein]; Xref=Rhea:RHEA:54728, CC Rhea:RHEA-COMP:10505, Rhea:RHEA-COMP:10506, ChEBI:CHEBI:57288, CC ChEBI:CHEBI:57384, ChEBI:CHEBI:83144, ChEBI:CHEBI:83145; EC=2.1.3.15; CC Evidence={ECO:0000256|ARBA:ARBA00001072, ECO:0000256|HAMAP- CC Rule:MF_00823}; CC -!- PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from CC acetyl-CoA: step 1/1. {ECO:0000256|ARBA:ARBA00004956, CC ECO:0000256|HAMAP-Rule:MF_00823}. CC -!- SUBUNIT: Acetyl-CoA carboxylase is a heterohexamer composed of biotin CC carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two CC subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta CC (AccD). {ECO:0000256|HAMAP-Rule:MF_00823}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00823}. CC -!- SIMILARITY: Belongs to the AccA family. {ECO:0000256|HAMAP- CC Rule:MF_00823}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GQ227672; ACT33034.1; -; Genomic_DNA. DR EMBL; GQ227673; ACT33035.1; -; Genomic_DNA. DR EMBL; GQ227674; ACT33036.1; -; Genomic_DNA. DR EMBL; HG969191; CDO47661.1; -; Genomic_DNA. DR EMBL; BLJS01000001; GFF02249.1; -; Genomic_DNA. DR EMBL; BLJT01000001; GFF04655.1; -; Genomic_DNA. DR RefSeq; WP_011181396.1; NZ_LOAI01000011.1. DR EnsemblBacteria; CDO47661; CDO47661; BM1374165_01689. DR GeneID; 64157770; -. DR KEGG; bhn:PRJBM_01621; -. DR KEGG; bhs:BM1374165_01689; -. DR PATRIC; fig|38323.3.peg.1882; -. DR OrthoDB; 886663at2; -. DR UniPathway; UPA00655; UER00711. DR Proteomes; UP000019801; Chromosome. DR Proteomes; UP000503821; Unassembled WGS sequence. DR Proteomes; UP000503841; Unassembled WGS sequence. DR GO; GO:0009317; C:acetyl-CoA carboxylase complex; IEA:InterPro. DR GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:InterPro. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0016743; F:carboxyl- or carbamoyltransferase activity; IEA:UniProtKB-UniRule. DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniRule. DR GO; GO:2001295; P:malonyl-CoA biosynthetic process; IEA:UniProtKB-UniPathway. DR HAMAP; MF_00823; AcetylCoA_CT_alpha; 1. DR InterPro; IPR001095; Acetyl_CoA_COase_a_su. DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf. DR InterPro; IPR011763; COA_CT_C. DR PANTHER; PTHR42853; PTHR42853; 1. DR Pfam; PF03255; ACCA; 1. DR PRINTS; PR01069; ACCCTRFRASEA. DR SUPFAM; SSF52096; SSF52096; 1. DR TIGRFAMs; TIGR00513; accA; 1. DR PROSITE; PS50989; COA_CT_CTER; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP- KW Rule:MF_00823}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00823}; KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160, ECO:0000256|HAMAP- KW Rule:MF_00823}; KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832, ECO:0000256|HAMAP- KW Rule:MF_00823}; KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516, ECO:0000256|HAMAP- KW Rule:MF_00823}; KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098, ECO:0000256|HAMAP- KW Rule:MF_00823}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP- KW Rule:MF_00823}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP- KW Rule:MF_00823}. FT DOMAIN 40..293 FT /note="CoA carboxyltransferase C-terminal" FT /evidence="ECO:0000259|PROSITE:PS50989" SQ SEQUENCE 318 AA; 34949 MW; 6C00D9F41B171DD4 CRC64; MYNYLDFEKP VADLDGKILE LKKISQEEGS LDMSDEIARL EMRSKTALRD IYKKLSPWQK TQVARHPDRP HFMDYSARLL SDVTPLAGDR KFAEDEAIQA GFARFKGEAV AYIGQEKGHD TQTRLRYNFG SARPEGYRKA VRIMEMADRF GLPLLTFVDT AGAYPGVSAE ERGQAEAIAQ STAATLRLKV PVVSVVIGEG GSGGAIAIAA ANKVYMLEHA IYSVISPEGA ASILWRDPTR AKDAAMNMRI TAQDLYQLKI IDGIIPEPLG GAHRGKEAVI DATGDIISFA LEAMAGKEGD VLKQERREKY LQIGRSLA //