ID C7DR73_9ARAC Unreviewed; 319 AA. AC C7DR73; DT 22-SEP-2009, integrated into UniProtKB/TrEMBL. DT 22-SEP-2009, sequence version 1. DT 02-MAR-2010, entry version 6. DE RecName: Full=Cytochrome c oxidase subunit 1; DE EC=1.9.3.1; DE Flags: Fragment; GN Name=COI; OS Sitalcina californica. OG Mitochondrion. OC Eukaryota; Metazoa; Arthropoda; Chelicerata; Arachnida; Opiliones; OC Laniatores; Gonyleptoidea; Phalangodidae; Sitalcina. OX NCBI_TaxID=656469; RN [1] RP NUCLEOTIDE SEQUENCE. RX PubMed=19699807; DOI=10.1016/j.ympev.2009.08.020; RA Hedin M., Thomas S.M.; RT "Molecular systematics of eastern North American Phalangodidae RT (Arachnida: Opiliones: Laniatores), demonstrating convergent RT morphological evolution in caves."; RL Mol. Phylogenet. Evol. 54:107-121(2010). CC -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory CC chain that catalyzes the reduction of oxygen to water. Subunits 1- CC 3 form the functional core of the enzyme complex. CO I is the CC catalytic subunit of the enzyme. Electrons originating in CC cytochrome c are transferred via the copper A center of subunit 2 CC and heme A of subunit 1 to the bimetallic center formed by heme A3 CC and copper B (By similarity). CC -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4 CC ferricytochrome c + 2 H(2)O. CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass CC membrane protein (By similarity). CC -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GQ200406; ACT98040.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW. DR GO; GO:0005507; F:copper ion binding; IEA:UniProtKB-KW. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:EC. DR GO; GO:0009055; F:electron carrier activity; IEA:InterPro. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0009060; P:aerobic respiration; IEA:InterPro. DR GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. DR GO; GO:0006810; P:transport; IEA:UniProtKB-KW. DR InterPro; IPR000883; Cyt_c_oxidase_su1. DR Gene3D; G3DSA:1.20.210.10; COX1; 1. DR PANTHER; PTHR10422; COX1; 1. DR Pfam; PF00115; COX1; 1. DR PRINTS; PR01165; CYCOXIDASEI. DR SUPFAM; SSF81442; COX1; 1. DR PROSITE; PS50855; COX1; 1. DR PROSITE; PS00077; COX1_CUB; 1. PE 3: Inferred from homology; KW Copper; Electron transport; Heme; Iron; Membrane; Metal-binding; KW Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; KW Respiratory chain; Transmembrane; Transport. FT NON_TER 1 1 FT NON_TER 319 319 SQ SEQUENCE 319 AA; 35440 MW; BDE853E42C342F5F CRC64; FWLLPPSLMF LMSASLINQG VGTGWTIYPP LVLYITYPDM SVDMVIFSLH LAGVSSILGA INFISTILNM QQKMMSMEQM PLFPWSILIT AILLLLSLPV LAGAITMLLT DRNFNTSFFD PAGGGDPILF QHLFWFFGHP EVYILILPGF GMISHIISFY ANKKTPFGTL GMIYAMSTIG ILGFVVWAHH SFTIGMDVDT RAYFTSATMI IAVPTGIKIF SWIATLYGSK LTNSPALWWA MGFVFLFTIG GITGVILANS SLDIILHDTY YVVAHFHYVL SMGAVFAIMG GFIHWSPLFI GVEMNKTMLN IQFMIMFIG //