ID C6G8E7_EBORE Unreviewed; 251 AA. AC C6G8E7; DT 01-SEP-2009, integrated into UniProtKB/TrEMBL. DT 01-SEP-2009, sequence version 1. DT 24-JUN-2015, entry version 9. DE RecName: Full=Membrane-associated protein VP24 {ECO:0000256|PIRNR:PIRNR011355}; GN Name=VP24 {ECO:0000313|EMBL:ACT22797.1}; OS Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola OS virus). OC Viruses; ssRNA viruses; ssRNA negative-strand viruses; OC Mononegavirales; Filoviridae; Ebolavirus. OX NCBI_TaxID=129003 {ECO:0000313|EMBL:ACT22797.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). OH NCBI_TaxID=9541; Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). OH NCBI_TaxID=77225; Pteropodinae. OH NCBI_TaxID=9823; Sus scrofa (Pig). RN [1] {ECO:0000313|EMBL:ACT22797.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Reston08-C {ECO:0000313|EMBL:ACT22797.1}; RX PubMed=19590002; DOI=10.1126/science.1172705; RA Barrette R.W., Metwally S.A., Rowland J.M., Xu L., Zaki S.R., RA Nichol S.T., Rollin P.E., Towner J.S., Shieh W.J., Batten B., RA Sealy T.K., Carrillo C., Moran K.E., Bracht A.J., Mayr G.A., RA Sirios-Cruz M., Catbagan D.P., Lautner E.A., Ksiazek T.G., White W.R., RA McIntosh M.T.; RT "Discovery of swine as a host for the Reston ebolavirus."; RL Science 325:204-206(2009). CC -!- FUNCTION: May act as a minor matrix protein that plays a role in CC assembly of viral nucleocapsid and virion budding. CC {ECO:0000256|PIRNR:PIRNR011355}. CC -!- SUBCELLULAR LOCATION: Virion membrane CC {ECO:0000256|PIRNR:PIRNR011355}; Peripheral membrane protein CC {ECO:0000256|PIRNR:PIRNR011355}. Host cell membrane CC {ECO:0000256|PIRNR:PIRNR011355}; Peripheral membrane protein CC {ECO:0000256|PIRNR:PIRNR011355}; Cytoplasmic side CC {ECO:0000256|PIRNR:PIRNR011355}. Host endomembrane system CC {ECO:0000256|PIRNR:PIRNR011355}; Peripheral membrane protein CC {ECO:0000256|PIRNR:PIRNR011355}. Note=In virion, localizes on the CC intravirional side of the membrane. In the host cell, it is found CC associated with virus-induced membrane proliferation foci and to CC the plasma membrane where budding takes place. CC {ECO:0000256|PIRNR:PIRNR011355}. CC -!- SIMILARITY: Belongs to the filoviridae membrane-associated protein CC VP24 family. {ECO:0000256|PIRNR:PIRNR011355}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FJ621584; ACT22797.1; -; Viral_cRNA. DR GO; GO:0033645; C:host cell endomembrane system; IEA:UniProtKB-SubCell. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR GO; GO:0016032; P:viral process; IEA:InterPro. DR InterPro; IPR009433; Filo_VP24. DR Pfam; PF06389; Filo_VP24; 1. DR PIRSF; PIRSF011355; VP24; 1. PE 3: Inferred from homology; KW Host cell membrane {ECO:0000256|PIRNR:PIRNR011355}; KW Host membrane {ECO:0000256|PIRNR:PIRNR011355}; KW Membrane {ECO:0000256|PIRNR:PIRNR011355}; KW Virion {ECO:0000256|PIRNR:PIRNR011355}. SQ SEQUENCE 251 AA; 28106 MW; 02B6BAF709C72277 CRC64; MAKATGRYNL VSPKKDMEKG VILSDLCNFL ITQTLQGWKV YWAGIEFDVS QKGMALLTRL KTNDFAPAWA MTRNLFPHLF QNPNSVIQSP IWALRVILAA GLQDQLLDHS LVEPLTGALG LISDWLLTTT STHFNLRTRS VKDQLSLRML SLIRSNILQF INKLDALHVV NYNGLLSSIE IGTSTHTIII TRTNMGFLVE VQEPDKSAMN SKHPGPVKFS LLHESAFKPF TRVPQSGMQS LIMEFNSLLA I //