ID C6G8E7_EBORE Unreviewed; 251 AA. AC C6G8E7; DT 01-SEP-2009, integrated into UniProtKB/TrEMBL. DT 01-SEP-2009, sequence version 1. DT 27-MAR-2024, entry version 25. DE RecName: Full=Membrane-associated protein VP24 {ECO:0000256|ARBA:ARBA00013875, ECO:0000256|PIRNR:PIRNR011355}; GN Name=VP24 {ECO:0000313|EMBL:ACT22797.1}; OS Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus). OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; OC Monjiviricetes; Mononegavirales; Filoviridae; Orthoebolavirus; OC Orthoebolavirus restonense; Reston ebolavirus. OX NCBI_TaxID=129003 {ECO:0000313|EMBL:ACT22797.1, ECO:0000313|Proteomes:UP000172901}; OH NCBI_TaxID=9606; Homo sapiens (Human). OH NCBI_TaxID=9541; Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). OH NCBI_TaxID=77225; Pteropodinae. OH NCBI_TaxID=9823; Sus scrofa (Pig). RN [1] {ECO:0000313|EMBL:ACT22797.1, ECO:0000313|Proteomes:UP000172901} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Reston08-C {ECO:0000313|EMBL:ACT22797.1}; RX PubMed=19590002; DOI=10.1126/science.1172705; RA Barrette R.W., Metwally S.A., Rowland J.M., Xu L., Zaki S.R., Nichol S.T., RA Rollin P.E., Towner J.S., Shieh W.J., Batten B., Sealy T.K., Carrillo C., RA Moran K.E., Bracht A.J., Mayr G.A., Sirios-Cruz M., Catbagan D.P., RA Lautner E.A., Ksiazek T.G., White W.R., McIntosh M.T.; RT "Discovery of swine as a host for the Reston ebolavirus."; RL Science 325:204-206(2009). CC -!- FUNCTION: May act as a minor matrix protein that plays a role in CC assembly of viral nucleocapsid and virion budding. CC {ECO:0000256|PIRNR:PIRNR011355}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413}; CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Endomembrane system CC {ECO:0000256|ARBA:ARBA00004184}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004184}. Host cell membrane CC {ECO:0000256|ARBA:ARBA00004501, ECO:0000256|PIRNR:PIRNR011355}; CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004501, CC ECO:0000256|PIRNR:PIRNR011355}; Cytoplasmic side CC {ECO:0000256|ARBA:ARBA00004501, ECO:0000256|PIRNR:PIRNR011355}. Host CC endomembrane system {ECO:0000256|ARBA:ARBA00004531, CC ECO:0000256|PIRNR:PIRNR011355}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004531, ECO:0000256|PIRNR:PIRNR011355}. CC Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004170}. Virion membrane CC {ECO:0000256|PIRNR:PIRNR011355}; Peripheral membrane protein CC {ECO:0000256|PIRNR:PIRNR011355}. Note=In virion, localizes on the CC intravirional side of the membrane. In the host cell, it is found CC associated with virus-induced membrane proliferation foci and to the CC plasma membrane where budding takes place. CC {ECO:0000256|PIRNR:PIRNR011355}. CC -!- SIMILARITY: Belongs to the filoviridae membrane-associated protein VP24 CC family. {ECO:0000256|ARBA:ARBA00006713, ECO:0000256|PIRNR:PIRNR011355}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FJ621584; ACT22797.1; -; Viral_cRNA. DR Proteomes; UP000172901; Genome. DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell. DR GO; GO:0033645; C:host cell endomembrane system; IEA:UniProtKB-SubCell. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR GO; GO:0019049; P:virus-mediated perturbation of host defense response; IEA:UniProtKB-KW. DR InterPro; IPR009433; Filo_VP24. DR Pfam; PF06389; Filo_VP24; 1. DR PIRSF; PIRSF011355; VP24; 1. PE 3: Inferred from homology; KW Host cell membrane {ECO:0000256|PIRNR:PIRNR011355}; KW Host membrane {ECO:0000256|PIRNR:PIRNR011355}; KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581}; KW Inhibition of host innate immune response by virus KW {ECO:0000256|ARBA:ARBA00023258}; KW Interferon antiviral system evasion {ECO:0000256|ARBA:ARBA00023258}; KW Membrane {ECO:0000256|PIRNR:PIRNR011355}; KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023258}; KW Virion {ECO:0000256|PIRNR:PIRNR011355}. SQ SEQUENCE 251 AA; 28106 MW; 02B6BAF709C72277 CRC64; MAKATGRYNL VSPKKDMEKG VILSDLCNFL ITQTLQGWKV YWAGIEFDVS QKGMALLTRL KTNDFAPAWA MTRNLFPHLF QNPNSVIQSP IWALRVILAA GLQDQLLDHS LVEPLTGALG LISDWLLTTT STHFNLRTRS VKDQLSLRML SLIRSNILQF INKLDALHVV NYNGLLSSIE IGTSTHTIII TRTNMGFLVE VQEPDKSAMN SKHPGPVKFS LLHESAFKPF TRVPQSGMQS LIMEFNSLLA I //