ID C5QSL7_STAEP Unreviewed; 332 AA. AC C5QSL7; DT 01-SEP-2009, integrated into UniProtKB/TrEMBL. DT 01-SEP-2009, sequence version 1. DT 30-NOV-2010, entry version 10. DE RecName: Full=Glycerol-3-phosphate dehydrogenase [NAD(P)+]; DE EC=1.1.1.94; DE AltName: Full=NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; GN Name=gpsA; ORFNames=HMPREF0793_2223; OS Staphylococcus epidermidis M23864:W1. OC Bacteria; Firmicutes; Bacillales; Staphylococcus. OX NCBI_TaxID=525378; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=M23864:W1; RA Qin X., Bachman B., Battles P., Bell A., Bess C., Bickham C., RA Chaboub L., Chen D., Coyle M., Deiros D.R., Dinh H., Forbes L., RA Fowler G., Francisco L., Fu Q., Gubbala S., Hale W., Han Y., RA Hemphill L., Highlander S.K., Hirani K., Hogues M., Jackson L., RA Jakkamsetti A., Javaid M., Jiang H., Korchina V., Kovar C., Lara F., RA Lee S., Mata R., Mathew T., Moen C., Morales K., Munidasa M., RA Nazareth L., Ngo R., Nguyen L., Okwuonu G., Ongeri F., Patil S., RA Petrosino J., Pham C., Pham P., Pu L.-L., Puazo M., Raj R., Reid J., RA Rouhana J., Saada N., Shang Y., Simmons D., Thornton R., Warren J., RA Weissenberger G., Zhang J., Zhang L., Zhou C., Zhu D., Muzny D., RA Worley K., Gibbs R.; RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: sn-glycerol 3-phosphate + NAD(P)(+) = CC glycerone phosphate + NAD(P)H. CC -!- PATHWAY: Membrane lipid metabolism; glycerophospholipid CC metabolism. CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC -!- SIMILARITY: Belongs to the NAD-dependent glycerol-3-phosphate CC dehydrogenase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; ACJB01000063; EES40120.1; -; Genomic_DNA. DR ProteinModelPortal; C5QSL7; -. DR GO; GO:0009331; C:glycerol-3-phosphate dehydrogenase complex; IEA:InterPro. DR GO; GO:0047952; F:glycerol-3-phosphate dehydrogenase [NAD(P)+...; IEA:HAMAP. DR GO; GO:0004367; F:glycerol-3-phosphate dehydrogenase [NAD+] a...; IEA:InterPro. DR GO; GO:0051287; F:NAD or NADH binding; IEA:InterPro. DR GO; GO:0046167; P:glycerol-3-phosphate biosynthetic process; IEA:HAMAP. DR GO; GO:0046168; P:glycerol-3-phosphate catabolic process; IEA:InterPro. DR GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW. DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:HAMAP. DR HAMAP; MF_00394; NAD_Glyc3P_dehydrog; 1; -. DR InterPro; IPR008927; 6-PGluconate_DH_C-like. DR InterPro; IPR013328; DH_multihelical. DR InterPro; IPR006168; G3P_DH_NAD-dep. DR InterPro; IPR006109; G3P_DH_NAD-dep_C. DR InterPro; IPR011128; G3P_DH_NAD-dep_N. DR InterPro; IPR016040; NAD(P)-bd_dom. DR Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1. DR Gene3D; G3DSA:1.10.1040.10; Opine_DH; 1. DR PANTHER; PTHR11728; NAD_Gly3P_DH; 1. DR Pfam; PF07479; NAD_Gly3P_dh_C; 1. DR Pfam; PF01210; NAD_Gly3P_dh_N; 1. DR PIRSF; PIRSF000114; Glycerol-3-P_dh; 1. DR PRINTS; PR00077; GPDHDRGNASE. DR SUPFAM; SSF48179; 6DGDH_C_like; 1. DR PROSITE; PS00957; NAD_G3PDH; 1. PE 3: Inferred from homology; KW Cytoplasm; NAD; Oxidoreductase; Phospholipid biosynthesis. FT NP_BIND 8 13 NAD (By similarity). FT REGION 256 257 Substrate binding (By similarity). FT ACT_SITE 192 192 Proton acceptor (By similarity). FT BINDING 106 106 NAD; via amide nitrogen (By similarity). FT BINDING 106 106 Substrate (By similarity). FT BINDING 141 141 NAD; via amide nitrogen (By similarity). FT BINDING 256 256 NAD (By similarity). FT BINDING 282 282 NAD (By similarity). SQ SEQUENCE 332 AA; 36070 MW; 7A7022EB471E869F CRC64; MTKITVFGMG SFGTALANVL AQNGHDVLMW GKNNDSVEEL NTHHMNKNYL KEAKLEESIQ ATTDLKQATQ FSDIFLMALP TKAMREVASN IDEMLESKKT FIHVAKGIEN GTFKRVSEML EDSISPEHNA GIGVLSGPSH AEEVVIKQPT TVAASSKDKK ISALIQDLFM NDYLRVYTNN DLVGVELGGA LKNIIAVASG IVAGMGFGDN AKAALMTRGL AEISRLGEKL GADPMTFLGL GGIGDLIVTC TSTHSRNFTL GYKLGQGKTM DDALKEMNMV VEGVYTTKSV YHLAKEENVD MPITSALYRV LFEDIPVKDS VKELMGRDKK AE //