ID C5QSC8_STAEP Unreviewed; 329 AA. AC C5QSC8; DT 01-SEP-2009, integrated into UniProtKB/TrEMBL. DT 01-SEP-2009, sequence version 1. DT 14-DEC-2011, entry version 15. DE SubName: Full=Aspartate-semialdehyde dehydrogenase; DE EC=1.2.1.11; GN Name=asd; ORFNames=HMPREF0793_2134; OS Staphylococcus epidermidis M23864:W1. OC Bacteria; Firmicutes; Bacillales; Staphylococcus. OX NCBI_TaxID=525378; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=M23864:W1; RA Qin X., Bachman B., Battles P., Bell A., Bess C., Bickham C., RA Chaboub L., Chen D., Coyle M., Deiros D.R., Dinh H., Forbes L., RA Fowler G., Francisco L., Fu Q., Gubbala S., Hale W., Han Y., RA Hemphill L., Highlander S.K., Hirani K., Hogues M., Jackson L., RA Jakkamsetti A., Javaid M., Jiang H., Korchina V., Kovar C., Lara F., RA Lee S., Mata R., Mathew T., Moen C., Morales K., Munidasa M., RA Nazareth L., Ngo R., Nguyen L., Okwuonu G., Ongeri F., Patil S., RA Petrosino J., Pham C., Pham P., Pu L.-L., Puazo M., Raj R., Reid J., RA Rouhana J., Saada N., Shang Y., Simmons D., Thornton R., Warren J., RA Weissenberger G., Zhang J., Zhang L., Zhou C., Zhu D., Muzny D., RA Worley K., Gibbs R.; RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the aspartate-semialdehyde dehydrogenase CC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; ACJB01000061; EES40262.1; -; Genomic_DNA. DR ProteinModelPortal; C5QSC8; -. DR PATRIC; 31396054; VBIStaEpi14170_0592. DR GO; GO:0005737; C:cytoplasm; IEA:InterPro. DR GO; GO:0004073; F:aspartate-semialdehyde dehydrogenase activity; IEA:EC. DR GO; GO:0003942; F:N-acetyl-gamma-glutamyl-phosphate reductase activity; IEA:InterPro. DR GO; GO:0051287; F:NAD binding; IEA:InterPro. DR GO; GO:0050661; F:NADP binding; IEA:InterPro. DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro. DR GO; GO:0009097; P:isoleucine biosynthetic process; IEA:InterPro. DR GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:InterPro. DR GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro. DR GO; GO:0009088; P:threonine biosynthetic process; IEA:InterPro. DR HAMAP; MF_02121; ASADH; 1; -. DR InterPro; IPR012080; Asp_semialdehyde_DH. DR InterPro; IPR005986; Asp_semialdehyde_DH_beta. DR InterPro; IPR016040; NAD(P)-bd_dom. DR InterPro; IPR000534; Semialdehyde_DH_NAD-bd. DR InterPro; IPR012280; Semialdhyde_DH_dimer_dom. DR Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1. DR Pfam; PF01118; Semialdhyde_dh; 1. DR Pfam; PF02774; Semialdhyde_dhC; 1. DR PIRSF; PIRSF000148; ASA_dh; 1. DR SMART; SM00859; Semialdhyde_dh; 1. DR TIGRFAMs; TIGR01296; Asd_B; 1. PE 3: Inferred from homology; KW Oxidoreductase. FT ACT_SITE 126 126 Acyl-thioester intermediate (By FT similarity). SQ SEQUENCE 329 AA; 36471 MW; 613003F4A58917F4 CRC64; MTRLAVAGAT GLVGTKMLET LDRKNIPFDE LVLFSSARSA GKKVEFQGQT YTVQELTDEA ASEHFDYVLM SAGGGTSEHF APLFEQAGAI VIDNSSQWRM TEDVDLVVPE VNEPKFTRGI IANPNCSTIQ SVVPLKILKD AYGLKRVAYT TYQAVSGSGI KGKRDLSEGA NGKEPEAYPH PIYNNVLPHI DVFLENGYTK EEQKMIDETR KILNDKDLKV TATCVRVPVQ DSHSIEIDVT LDKDATVKDI QRLFEQDDRV VLVDNPEKNE YPLAIHSTGK DEVFVGRIRR DDSLDNTFHV WCTSDNLLKG AALNAVQVLE QVLTLKGAR //