ID   C5NMX7_9COLE            Unreviewed;       335 AA.
AC   C5NMX7;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   19-JAN-2022, entry version 42.
DE   RecName: Full=NADH dehydrogenase subunit 5 {ECO:0000256|ARBA:ARBA00019470};
DE            EC=7.1.1.2 {ECO:0000256|ARBA:ARBA00012944};
DE   AltName: Full=NADH-ubiquinone oxidoreductase chain 5 {ECO:0000256|ARBA:ARBA00021096};
DE   Flags: Fragment;
GN   Name=ND5 {ECO:0000313|EMBL:BAH82756.1};
OS   Luciola kuroiwae.
OG   Mitochondrion {ECO:0000313|EMBL:BAH82756.1}.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia; Elateroidea;
OC   Lampyridae; Luciolinae; Luciola.
OX   NCBI_TaxID=71211 {ECO:0000313|EMBL:BAH82756.1};
RN   [1] {ECO:0000313|EMBL:BAH82756.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=07507C_a {ECO:0000313|EMBL:BAH82756.1};
RC   TISSUE=Metathorax {ECO:0000313|EMBL:BAH82756.1};
RA   Hiyori Y., Inoue D., Mizuno T., Kusaoke H.;
RT   "Molecular phylogeny and genetic differentiation of Japanese firefly
RT   Luciola parvula, (Coleoptera: Lampyridae) estimated from mitochondrial ND5
RT   gene sequences.";
RL   Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) that is believed to belong to the
CC       minimal assembly required for catalysis. Complex I functions in the
CC       transfer of electrons from NADH to the respiratory chain. The immediate
CC       electron acceptor for the enzyme is believed to be ubiquinone.
CC       {ECO:0000256|ARBA:ARBA00003257}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00000766};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC       inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane
CC       protein {ECO:0000256|ARBA:ARBA00004448}.
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DR   EMBL; AB436478; BAH82756.1; -; Genomic_DNA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR010934; NADH_DH_su5_C.
DR   InterPro; IPR003945; NADHpl_OxRdtase_5.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   PANTHER; PTHR42829; PTHR42829; 1.
DR   Pfam; PF06455; NADH5_C; 1.
DR   Pfam; PF00361; Proton_antipo_M; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128, ECO:0000313|EMBL:BAH82756.1};
KW   Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        38..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        63..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        99..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        143..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        186..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        222..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        253..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        311..334
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          7..150
FT                   /note="Proton_antipo_M"
FT                   /evidence="ECO:0000259|Pfam:PF00361"
FT   DOMAIN          159..335
FT                   /note="NADH5_C"
FT                   /evidence="ECO:0000259|Pfam:PF06455"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAH82756.1"
FT   NON_TER         335
FT                   /evidence="ECO:0000313|EMBL:BAH82756.1"
SQ   SEQUENCE   335 AA;  39568 MW;  1F7B8DF6B0A1449E CRC64;
     RFNFCLTENL MNFMLFFSMM TMFMSGLGAN FEYDLKKIIA LSTLSQLGLM MSILFLGDYN
     LAFFHLLSHA LFKALLFMCA GCIIHNLMNC QDIRYMGSLI NLMPLTCTFF NISNFSLCGL
     PFLSGFYSKD LILEIFSMNY FNLFVYFIFY ISIGLTVSYS FRLSYYMLFN SYNFYSLNSL
     NDQGFIMLKG MGGLITFVIF GGCMLSWLMF PTPYFICLSF NLKMMVIFFI MIGLFLGYEF
     SKFNFNYKLK SNNLLSLFLS SMWNMPMLST YLVNFYFLKF SDFYYKNVDM GWFEYFGSQN
     LYQNIKYNSK IFQLLFNNNL KIYFVFLIIF ILLLI
//