ID   C5MLF8_9INFA            Unreviewed;       757 AA.
AC   C5MLF8;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   09-JAN-2013, entry version 22.
DE   RecName: Full=RNA-directed RNA polymerase catalytic subunit;
DE            EC=2.7.7.48;
GN   Name=PB1;
OS   Influenza A virus (A/chicken/Bali/UT2091/2005(H5N1)).
OC   Viruses; ssRNA negative-strand viruses; Orthomyxoviridae;
OC   Influenzavirus A.
OX   NCBI_TaxID=644241;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=A/chicken/Bali/UT2091/2005;
RX   PubMed=19464724; DOI=10.1016/j.virol.2009.04.024;
RA   Takano R., Nidom C.A., Kiso M., Muramoto Y., Yamada S.,
RA   Sakai-Tagawa Y., Macken C., Kawaoka Y.;
RT   "Phylogenetic characterization of H5N1 avian influenza viruses
RT   isolated in Indonesia from 2003-2007.";
RL   Virology 390:13-21(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=A/chicken/Bali/UT2091/2005;
RA   Tankano R.;
RL   Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate
CC       + RNA(n+1).
CC   -!- SIMILARITY: Contains 1 RdRp catalytic domain.
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DR   EMBL; GQ122467; ACR49100.1; -; Viral_cRNA.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0003968; F:RNA-directed RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0039523; P:suppression by virus of host RNA polymerase II activity; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0019079; P:viral genome replication; IEA:InterPro.
DR   InterPro; IPR007099; RNA-dir_pol_NSvirus.
DR   InterPro; IPR001407; RNA_pol_PB1_influenza.
DR   Pfam; PF00602; Flu_PB1; 1.
DR   PIRSF; PIRSF000827; RdRPol_OMV; 1.
DR   PROSITE; PS50525; RDRP_SSRNA_NEG_SEG; 1.
PE   4: Predicted;
KW   Host gene expression shutoff by virus;
KW   Host transcription shutoff by virus; Host-virus interaction;
KW   Inhibition of host RNA polymerase II by virus; Nucleotide-binding;
KW   Nucleotidyltransferase; RNA-directed RNA polymerase; Transferase;
KW   Viral RNA replication.
SQ   SEQUENCE   757 AA;  86477 MW;  DE779D877312DF54 CRC64;
     MDVNPTLLFL KVPVQNAIST TFPYTGDPPY SHGTGTGYTM DTVNRTHQYS EKGKWTTNTE
     TGAPQLNPID GPLPEDNEPS GYAQTDCVLE AMAFLEESHP GIFENSCLET MEIVQQTRVD
     KLTQGRQTYD WTLNRNQPAA TALANTIEIF RSNGLTANES GRLIDFLKDV MESMDKEEME
     ITTHFQRKRR VRDNMTKKMV TQRTIGKKKQ RLNKRSYLIR ALTLNTMTKD AERGKLKRRA
     IATPGMQIRG FVYFVETLAR SICEKLEQSG LPVGGNEKKA KLANVVRKMM TNSQDTELSF
     TITGDNTKWN ENQNPRMFLA MITYITRNQP EWFRNVLSIA PIMFSNKMAR LGKGYMFESK
     SMKLRTQIPA EMLANIDLKY FNELTKKKIE KIRPLLIDGA ASLSPGMMMG MFNMLSTVLG
     VSILNLGQKR YTKTTYWWDG LQSSDDFALI VNAPNHEGIQ AGVDRFYRTC KLVGINMSKK
     KSYINRTGTF EFTSFFYRYG FVANFSMELP SFGVSGINES ADMSIGVTVI KNNMINNDLG
     PATAQMALQL FIKDYRYTYR CHRGDTQIQT RRSFELKKLW EQTRSKAGLL VSDGGPNLYN
     IRNLHIPEVC LKWELMDEDY QGRLCNPLNP FVSHKEIESV NNAVVMPAHG PAKSMEYDAV
     ATTHSWIPKR NRSILNTSQR GILEDEQMYQ KCCNLFEKFF PSSSYRRPVG ISSMVEAMVS
     RARIDARIDF ESGRIKKEEF AEIMKICSTI EELRRQK
//