ID C5MLF0_9INFA Unreviewed; 90 AA. AC C5MLF0; DT 28-JUL-2009, integrated into UniProtKB/TrEMBL. DT 28-JUL-2009, sequence version 1. DT 15-JUN-2010, entry version 8. DE SubName: Full=PB1-F2 protein; GN Name=PB1-F2; OS Influenza A virus (A/duck/East Java/UT1107/2004(H5N1)). OC Viruses; ssRNA negative-strand viruses; Orthomyxoviridae; OC Influenzavirus A. OX NCBI_TaxID=644262; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/duck/East Java/UT1107/2004; RX PubMed=19464724; DOI=10.1016/j.virol.2009.04.024; RA Takano R., Nidom C.A., Kiso M., Muramoto Y., Yamada S., RA Sakai-Tagawa Y., Macken C., Kawaoka Y.; RT "Phylogenetic characterization of H5N1 avian influenza viruses RT isolated in Indonesia from 2003-2007."; RL Virology 390:13-21(2009). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/duck/East Java/UT1107/2004; RA Tankano R.; RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Plays an important role in promoting lung pathology in CC both primary viral infection and secondary bacterial infection. CC Promotes alteration of mitochondrial morphology, dissipation of CC mitochondrial membrane potential, and cell death. Its level of CC expression differ greatly depending on which cell type is CC infected, in a manner that is independent of the levels of CC expression of other viral proteins. Monocytic cells are more CC affected than epithelial cells. Seems to disable virus-infected CC monocytes or other host innate immune cells. May also act in CC trans: extracellular PB1-F2 released by infected cells could CC potentially inactivate hosts cell recruitment to the site of CC infection. During early stage of infection, may predispose the CC mitochondria to permeability transition through interaction with CC human SLC25A6/ANT3 and VDAC1. These proteins participate in the CC formation of the permeability transition pore complex (PTPC) CC responsible of the release of mitochondrial products that triggers CC apoptosis (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GQ122461; ACR49099.1; -; Viral_cRNA. DR SMR; C5MLF0; 51-87. DR GO; GO:0044192; C:host cell mitochondrial inner membrane; IEA:UniProtKB-KW. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-KW. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0006915; P:apoptosis; IEA:UniProtKB-KW. DR GO; GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW. DR InterPro; IPR021045; Flu_proapoptotic_PB1-F2. DR Pfam; PF11986; PB1-F2; 1. PE 3: Inferred from homology; KW Apoptosis; Host cytoplasm; Host membrane; Host mitochondrion; KW Host mitochondrion inner membrane; Host nucleus; KW Host-virus interaction; Membrane. SQ SEQUENCE 90 AA; 10845 MW; 0F4E97AED6F01678 CRC64; MEQGQDTPWT QSTEHTNIQK RGSGQQTQRL EHPNSTRLMD HYLRIMSPVG MHKQIVYWKQ WLSLKNPTQG SLKTRVLKRW KLFNKQEWIN //