ID C5MLF0_9INFA Unreviewed; 90 AA. AC C5MLF0; DT 28-JUL-2009, integrated into UniProtKB/TrEMBL. DT 28-JUL-2009, sequence version 1. DT 30-NOV-2016, entry version 37. DE RecName: Full=Protein PB1-F2 {ECO:0000256|SAAS:SAAS00019965}; GN Name=PB1-F2 {ECO:0000313|EMBL:ACR49099.1}; OS Influenza A virus (A/duck/East Java/UT1107/2004(H5N1)). OC Viruses; ssRNA viruses; ssRNA negative-strand viruses; OC Orthomyxoviridae; Influenzavirus A. OX NCBI_TaxID=644262 {ECO:0000313|EMBL:ACR49099.1}; RN [1] {ECO:0000313|EMBL:ACR49099.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/duck/East Java/UT1107/2004 {ECO:0000313|EMBL:ACR49099.1}; RX PubMed=19464724; DOI=10.1016/j.virol.2009.04.024; RA Takano R., Nidom C.A., Kiso M., Muramoto Y., Yamada S., RA Sakai-Tagawa Y., Macken C., Kawaoka Y.; RT "Phylogenetic characterization of H5N1 avian influenza viruses RT isolated in Indonesia from 2003-2007."; RL Virology 390:13-21(2009). RN [2] {ECO:0000313|EMBL:ACR49099.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/duck/East Java/UT1107/2004 {ECO:0000313|EMBL:ACR49099.1}; RA Tankano R.; RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Plays an important role in promoting lung pathology in CC both primary viral infection and secondary bacterial infection. CC Promotes alteration of mitochondrial morphology, dissipation of CC mitochondrial membrane potential, and cell death. Alternatively, CC inhibits the production of interferon in the infected cell at the CC level of host mitochondrial antiviral signaling MAVS. Its level of CC expression differs greatly depending on which cell type is CC infected, in a manner that is independent of the levels of CC expression of other viral proteins. Monocytic cells are more CC affected than epithelial cells. Seems to disable virus-infected CC monocytes or other host innate immune cells. May also act in CC trans: extracellular PB1-F2 released by infected cells could CC potentially inactivate hosts cell recruitment to the site of CC infection. During early stage of infection, may predispose the CC mitochondria to permeability transition through interaction with CC human SLC25A6/ANT3 and VDAC1. These proteins participate in the CC formation of the permeability transition pore complex (PTPC) CC responsible of the release of mitochondrial products that triggers CC apoptosis. {ECO:0000256|SAAS:SAAS00019973}. CC -!- SUBCELLULAR LOCATION: Host cytoplasm, host cytosol CC {ECO:0000256|SAAS:SAAS00542543}. CC -!- SUBCELLULAR LOCATION: Host mitochondrion inner membrane CC {ECO:0000256|SAAS:SAAS00542574}. CC -!- SUBCELLULAR LOCATION: Host nucleus CC {ECO:0000256|SAAS:SAAS00542458}. CC -!- SIMILARITY: Belongs to the influenza viruses PB1-F2 family. CC {ECO:0000256|SAAS:SAAS00542629}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GQ122461; ACR49099.1; -; Viral_cRNA. DR ProteinModelPortal; C5MLF0; -. DR GO; GO:0044164; C:host cell cytosol; IEA:UniProtKB-SubCell. DR GO; GO:0044192; C:host cell mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW. DR GO; GO:0039545; P:suppression by virus of host MAVS activity; IEA:UniProtKB-KW. DR InterPro; IPR021045; Flu_proapoptotic_PB1-F2. DR Pfam; PF11986; PB1-F2; 1. PE 3: Inferred from homology; KW Apoptosis {ECO:0000256|SAAS:SAAS00426053}; KW Host cytoplasm {ECO:0000256|SAAS:SAAS00426077}; KW Host membrane {ECO:0000256|SAAS:SAAS00426056}; KW Host mitochondrion {ECO:0000256|SAAS:SAAS00426061}; KW Host mitochondrion inner membrane {ECO:0000256|SAAS:SAAS00426055}; KW Host nucleus {ECO:0000256|SAAS:SAAS00426101}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS00426033}; KW Inhibition of host innate immune response by virus KW {ECO:0000256|SAAS:SAAS00426036}; KW Inhibition of host MAVS by virus {ECO:0000256|SAAS:SAAS00426083}; KW Inhibition of host RLR pathway by virus KW {ECO:0000256|SAAS:SAAS00426099}; KW Membrane {ECO:0000256|SAAS:SAAS00426100}; KW Modulation of host cell apoptosis by virus KW {ECO:0000256|SAAS:SAAS00426070}; KW Viral immunoevasion {ECO:0000256|SAAS:SAAS00426036}. FT DOMAIN 1 87 PB1-F2. {ECO:0000259|Pfam:PF11986}. SQ SEQUENCE 90 AA; 10845 MW; 0F4E97AED6F01678 CRC64; MEQGQDTPWT QSTEHTNIQK RGSGQQTQRL EHPNSTRLMD HYLRIMSPVG MHKQIVYWKQ WLSLKNPTQG SLKTRVLKRW KLFNKQEWIN //