ID C5MLE1_9INFA Unreviewed; 90 AA. AC C5MLE1; DT 28-JUL-2009, integrated into UniProtKB/TrEMBL. DT 28-JUL-2009, sequence version 1. DT 11-DEC-2019, entry version 50. DE RecName: Full=Protein PB1-F2 {ECO:0000256|HAMAP-Rule:MF_04064, ECO:0000256|SAAS:SAAS01037961}; GN Name=PB1-F2 {ECO:0000313|EMBL:ACR49097.1}; GN Synonyms=PB1 {ECO:0000256|HAMAP-Rule:MF_04064}; OS Influenza A virus (A/quail/Yogjakarta/UT1075/2004(H5N1)). OC Viruses; Riboviria; Negarnaviricota; Polyploviricotina; Insthoviricetes; OC Articulavirales; Orthomyxoviridae; Alphainfluenzavirus. OX NCBI_TaxID=644264 {ECO:0000313|EMBL:ACR49097.1, ECO:0000313|Proteomes:UP000113142}; RN [1] {ECO:0000313|EMBL:ACR49097.1, ECO:0000313|Proteomes:UP000113142} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=A/quail/Yogjakarta/UT1075/2004 {ECO:0000313|EMBL:ACR49097.1}; RX PubMed=19464724; DOI=10.1016/j.virol.2009.04.024; RA Takano R., Nidom C.A., Kiso M., Muramoto Y., Yamada S., Sakai-Tagawa Y., RA Macken C., Kawaoka Y.; RT "Phylogenetic characterization of H5N1 avian influenza viruses isolated in RT Indonesia from 2003-2007."; RL Virology 390:13-21(2009). CC -!- FUNCTION: May play an important role in promoting lung pathology in CC both primary viral infection and secondary bacterial infection. CC {ECO:0000256|HAMAP-Rule:MF_04064}. CC -!- FUNCTION: Plays an important role in promoting lung pathology in both CC primary viral infection and secondary bacterial infection. Promotes CC alteration of mitochondrial morphology, dissipation of mitochondrial CC membrane potential, and cell death. Alternatively, inhibits the CC production of interferon in the infected cell at the level of host CC mitochondrial antiviral signaling MAVS. Its level of expression differs CC greatly depending on which cell type is infected, in a manner that is CC independent of the levels of expression of other viral proteins. CC Monocytic cells are more affected than epithelial cells. Seems to CC disable virus-infected monocytes or other host innate immune cells. CC During early stage of infection, predisposes the mitochondria to CC permeability transition through interaction with host SLC25A6/ANT3 and CC VDAC1. These proteins participate in the formation of the permeability CC transition pore complex (PTPC) responsible of the release of CC mitochondrial products that triggers apoptosis. CC {ECO:0000256|SAAS:SAAS01037965}. CC -!- SUBUNIT: Oligomer. Interacts with human SLC25A6/ANT3 and VDAC1. CC Interacts with host MAVS. {ECO:0000256|SAAS:SAAS01037954}. CC -!- SUBCELLULAR LOCATION: Host cytoplasm, host cytosol {ECO:0000256|HAMAP- CC Rule:MF_04064, ECO:0000256|SAAS:SAAS01037928}. Host mitochondrion inner CC membrane {ECO:0000256|SAAS:SAAS01037967}. Host nucleus CC {ECO:0000256|HAMAP-Rule:MF_04064}. CC -!- SIMILARITY: Belongs to the influenza viruses PB1-F2 family. CC {ECO:0000256|HAMAP-Rule:MF_04064, ECO:0000256|SAAS:SAAS01037930}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GQ122455; ACR49097.1; -; Viral_cRNA. DR SMR; C5MLE1; -. DR Proteomes; UP000113142; Genome. DR GO; GO:0044164; C:host cell cytosol; IEA:UniProtKB-SubCell. DR GO; GO:0044192; C:host cell mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule. DR GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW. DR GO; GO:0039545; P:suppression by virus of host MAVS activity; IEA:UniProtKB-KW. DR HAMAP; MF_04064; INFV_PB1F2; 1. DR InterPro; IPR021045; Flu_proapoptotic_PB1-F2. DR Pfam; PF11986; PB1-F2; 1. PE 3: Inferred from homology; KW Apoptosis {ECO:0000256|SAAS:SAAS01037942}; KW Host cytoplasm {ECO:0000256|HAMAP-Rule:MF_04064, KW ECO:0000256|SAAS:SAAS01037927}; KW Host membrane {ECO:0000256|SAAS:SAAS01037929}; KW Host mitochondrion {ECO:0000256|SAAS:SAAS01037964}; KW Host mitochondrion inner membrane {ECO:0000256|SAAS:SAAS01037958}; KW Host nucleus {ECO:0000256|HAMAP-Rule:MF_04064, KW ECO:0000256|SAAS:SAAS01037963}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS01037966}; KW Inhibition of host innate immune response by virus KW {ECO:0000256|SAAS:SAAS01037962}; KW Inhibition of host MAVS by virus {ECO:0000256|SAAS:SAAS01037948}; KW Inhibition of host RLR pathway by virus {ECO:0000256|SAAS:SAAS01037933}; KW Membrane {ECO:0000256|SAAS:SAAS01037959}; KW Modulation of host cell apoptosis by virus {ECO:0000256|SAAS:SAAS01037955}; KW Viral immunoevasion {ECO:0000256|SAAS:SAAS01037962}. FT REGION 1..34 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..33 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 90 AA; 10845 MW; 0F4E97AED6F01678 CRC64; MEQGQDTPWT QSTEHTNIQK RGSGQQTQRL EHPNSTRLMD HYLRIMSPVG MHKQIVYWKQ WLSLKNPTQG SLKTRVLKRW KLFNKQEWIN //