ID   C5M5W0_CANTT            Unreviewed;       505 AA.
AC   C5M5W0;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   13-SEP-2023, entry version 71.
DE   RecName: Full=General transcription and DNA repair factor IIH {ECO:0000256|PIRNR:PIRNR015919};
GN   ORFNames=CTRG_01241 {ECO:0000313|EMBL:EER34380.1};
OS   Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=294747 {ECO:0000313|EMBL:EER34380.1, ECO:0000313|Proteomes:UP000002037};
RN   [1] {ECO:0000313|EMBL:EER34380.1, ECO:0000313|Proteomes:UP000002037}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-3404 / T1 {ECO:0000313|Proteomes:UP000002037};
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA   Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA   Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA   Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA   Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA   Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA   Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Component of the general transcription and DNA repair factor
CC       IIH (TFIIH) core complex, which is involved in general and
CC       transcription-coupled nucleotide excision repair (NER) of damaged DNA
CC       and, when complexed to TFIIK, in RNA transcription by RNA polymerase
CC       II. {ECO:0000256|PIRNR:PIRNR015919}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PIRNR:PIRNR015919}.
CC   -!- SIMILARITY: Belongs to the GTF2H2 family.
CC       {ECO:0000256|ARBA:ARBA00006092, ECO:0000256|PIRNR:PIRNR015919}.
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DR   EMBL; GG692396; EER34380.1; -; Genomic_DNA.
DR   RefSeq; XP_002546935.1; XM_002546889.1.
DR   AlphaFoldDB; C5M5W0; -.
DR   STRING; 5482.XP_002546935.1; -.
DR   EnsemblFungi; CTRG_01241-t43_1; CTRG_01241-t43_1-p1; CTRG_01241.
DR   GeneID; 8297513; -.
DR   KEGG; ctp:CTRG_01241; -.
DR   VEuPathDB; FungiDB:CTRG_01241; -.
DR   eggNOG; KOG2807; Eukaryota.
DR   HOGENOM; CLU_028556_2_0_1; -.
DR   OrthoDB; 276422at2759; -.
DR   Proteomes; UP000002037; Unassembled WGS sequence.
DR   GO; GO:0000112; C:nucleotide-excision repair factor 3 complex; IEA:EnsemblFungi.
DR   GO; GO:0000439; C:transcription factor TFIIH core complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005675; C:transcription factor TFIIH holo complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:EnsemblFungi.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:UniProtKB-UniRule.
DR   GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:EnsemblFungi.
DR   CDD; cd00065; FYVE_like_SF; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR046349; C1-like_sf.
DR   InterPro; IPR007198; Ssl1-like.
DR   InterPro; IPR004595; TFIIH_C1-like_dom.
DR   InterPro; IPR012170; TFIIH_SSL1/p44.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   NCBIfam; TIGR00622; ssl1; 1.
DR   PANTHER; PTHR12695; GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2; 1.
DR   PANTHER; PTHR12695:SF2; GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED; 1.
DR   Pfam; PF07975; C1_4; 1.
DR   Pfam; PF04056; Ssl1; 1.
DR   PIRSF; PIRSF015919; TFIIH_SSL1; 1.
DR   SMART; SM01047; C1_4; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR015919};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR015919};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002037};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|PIRNR:PIRNR015919};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|PIRNR:PIRNR015919};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRNR:PIRNR015919};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00042}.
FT   DOMAIN          109..304
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   DOMAIN          475..498
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   ZN_FING         393..410
FT                   /note="C4-type"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR015919-1"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..47
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   505 AA;  56250 MW;  866C66D86232A515 CRC64;
     MDDSDEEYVR TNSPSSKLSS EVPEAKASPR DKNGVSTRTR SSRRGEVSDL KGANGYAWED
     EYQRSWDIVK DDESGSNSFE AMVQSIIENR KKKIMKNPST PFQRGIIRTL VIIIDGSSVM
     SEKDLRPNRL SMTLSYLQDF VTEFFDQNPI SRLGIILMRN GIANLVSEVS GSPQYHIDKI
     RQLKARQHNR FEPKGDPSLQ NSLEMARSLL KFNFGSTSNN TKNSKEVLII FGALFTSDPG
     DIHRTIDNLI KDEIKVSVIG LSAQVAICQE LVNRTNKEPR NSQSKHYGVI MNESHFKELL
     MDSVTPLPLT ESEKRLQDAQ SEDGGVPVLR MGFPSKVQPT LTSVVTGTDM IIEFPHLNAS
     FPTQGSEDSK DAVEIQNNRA VAAASSSVIG YQCPQCKSKV CNLPTLCPVC GLMLILSTHL
     ARSYHHLVPL AQFKEVPVAP VYDSEFCFGC QLKFPDGVKA GTQKGSLESM TSSRYRCKRC
     EKSFCINCDV FVHEVLHTCP GCENM
//