ID C5IYE4_HUMAN Unreviewed; 366 AA. AC C5IYE4; DT 28-JUL-2009, integrated into UniProtKB/TrEMBL. DT 28-JUL-2009, sequence version 1. DT 11-NOV-2015, entry version 49. DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:ACR78564.1}; GN Name=HLA-Cw {ECO:0000313|EMBL:ACR78564.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ACR78564.1}; RN [1] {ECO:0000313|EMBL:ACR78564.1} RP NUCLEOTIDE SEQUENCE. RA Cheng L., Zou H., Zhu W., Du J., Li Z., Jin S., Wang D., Gao S., RA Cheng X., Tian Z.; RT "Homo sapiens major histocompatibility complex class I, Cw, genomic RT sequence."; RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ACV91117.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=21707542; DOI=10.1111/j.1399-0039.2011.01724.x; RA Xu Y., Sun Y., He L., Deng Z.; RT "Characterization of the genomic full-length sequence of C*04:03 and RT C*04:06 in Chinese Han individuals."; RL Tissue Antigens 78:402-403(2011). CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system. {ECO:0000256|SAAS:SAAS00281819}. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC -!- SIMILARITY: Contains Ig-like C1-type (immunoglobulin-like) domain. CC {ECO:0000256|SAAS:SAAS00291809}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FJ973627; ACR78564.1; -; Genomic_DNA. DR EMBL; GQ472837; ACV91117.1; -; Genomic_DNA. DR UniGene; Hs.656020; -. DR UniGene; Hs.743218; -. DR UniGene; Hs.77961; -. DR PRIDE; C5IYE4; -. DR NextBio; 35482770; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0042605; F:peptide antigen binding; IEA:InterPro. DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.30.500.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR027648; MHC_I_a. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Disulfide bond {ECO:0000256|SAAS:SAAS00281758}; KW Immunity {ECO:0000256|SAAS:SAAS00281824}; KW Membrane {ECO:0000256|SAAS:SAAS00281753, ECO:0000256|SAM:Phobius}; KW MHC I {ECO:0000256|SAAS:SAAS00281777}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00281848, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00281807, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 FT CHAIN 25 366 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002953445. FT TRANSMEM 306 331 Helical. {ECO:0000256|SAM:Phobius}. SQ SEQUENCE 366 AA; 40946 MW; DE2A28A5C13BDBCE CRC64; MRVMAPRTLI LLLSGALALT ETWAGSHSMR YFYTAVSRPS RGEPHFIAVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV NLRKLRGYYN QSEDGSHTLQ RMFGCDLGPD GRLLRGYNQF AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQR RAYLEGTCVE WLRRYLENGK ETLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQWDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWKP SSQPTIPIVG IVAGLAVLAV LAVLGAVVAV VMCRRKSSGG KGGSCSQAAS SNSAQGSDES LIACKA //