ID   C5IYE4_HUMAN            Unreviewed;       366 AA.
AC   C5IYE4;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   28-NOV-2012, entry version 31.
DE   SubName: Full=MHC class I antigen;
GN   Name=HLA-Cw;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Cheng L., Zou H., Zhu W., Du J., Li Z., Jin S., Wang D., Gao S.,
RA   Cheng X., Tian Z.;
RT   "Homo sapiens major histocompatibility complex class I, Cw, genomic
RT   sequence.";
RL   Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=21707542; DOI=10.1111/j.1399-0039.2011.01724.x;
RA   Xu Y., Sun Y., He L., Deng Z.;
RT   "Characterization of the genomic full-length sequence of C*04:03 and
RT   C*04:06 in Chinese Han individuals.";
RL   Tissue Antigens 78:402-403(2011).
CC   -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC       immune system (By similarity).
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC   -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like)
CC       domain.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FJ973627; ACR78564.1; -; Genomic_DNA.
DR   EMBL; GQ472837; ACV91117.1; -; Genomic_DNA.
DR   IPI; IPI00472605; -.
DR   UniGene; Hs.654404; -.
DR   UniGene; Hs.656020; -.
DR   STRING; C5IYE4; -.
DR   PRIDE; C5IYE4; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   Gene3D; 2.60.40.10; Ig-like_fold; 1.
DR   Gene3D; 3.30.500.10; MHC_I-like_Ag-recog; 1.
DR   InterPro; IPR007110; Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011161; MHC_I-like_Ag-recog.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR001039; MHC_I_a_a1/a2.
DR   InterPro; IPR010579; MHC_I_a_C.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF54452; MHC_I/II-like_Ag-recog; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Immunity; Membrane; MHC I; Transmembrane;
KW   Transmembrane helix.
SQ   SEQUENCE   366 AA;  40946 MW;  DE2A28A5C13BDBCE CRC64;
     MRVMAPRTLI LLLSGALALT ETWAGSHSMR YFYTAVSRPS RGEPHFIAVG YVDDTQFVRF
     DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV NLRKLRGYYN QSEDGSHTLQ
     RMFGCDLGPD GRLLRGYNQF AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQR
     RAYLEGTCVE WLRRYLENGK ETLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT
     WQWDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWKP
     SSQPTIPIVG IVAGLAVLAV LAVLGAVVAV VMCRRKSSGG KGGSCSQAAS SNSAQGSDES
     LIACKA
//