ID C5IYE4_HUMAN Unreviewed; 366 AA. AC C5IYE4; DT 28-JUL-2009, integrated into UniProtKB/TrEMBL. DT 28-JUL-2009, sequence version 1. DT 05-OCT-2010, entry version 14. DE SubName: Full=MHC class I antigen; GN Name=HLA-Cw; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RA Cheng L., Zou H., Zhu W., Du J., Li Z., Jin S., Wang D., Gao S., RA Cheng X., Tian Z.; RT "Homo sapiens major histocompatibility complex class I, Cw, genomic RT sequence."; RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE. RA Xu Y., Deng Z., Wang D.; RT "Characterization and polymorphism analyses of HLA-C genomic full RT length in Chinese Han population."; RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in the presentation of foreign antigens to the CC immune system (By similarity). CC -!- SIMILARITY: Belongs to the MHC class I family. CC -!- SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like) CC domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FJ973627; ACR78564.1; -; Genomic_DNA. DR EMBL; GQ472837; ACV91117.1; -; Genomic_DNA. DR IPI; IPI00745649; -. DR UniGene; Hs.654404; -. DR UniGene; Hs.656020; -. DR UniGene; Hs.77961; -. DR ProteinModelPortal; C5IYE4; -. DR Ensembl; ENST00000457903; ENSP00000390851; ENSG00000225691. DR HGNC; HGNC:4933; HLA-C. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW. DR GO; GO:0002474; P:antigen processing and presentation of pept...; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR InterPro; IPR007110; Ig-like. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1. DR Gene3D; G3DSA:3.30.500.10; MHC_I-like_Ag-recog; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF54452; MHC_I/II-like_Ag-recog; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Immunity; Membrane; MHC I; Transmembrane; Transmembrane helix. SQ SEQUENCE 366 AA; 40946 MW; DE2A28A5C13BDBCE CRC64; MRVMAPRTLI LLLSGALALT ETWAGSHSMR YFYTAVSRPS RGEPHFIAVG YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV NLRKLRGYYN QSEDGSHTLQ RMFGCDLGPD GRLLRGYNQF AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQR RAYLEGTCVE WLRRYLENGK ETLQRAEHPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQWDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWKP SSQPTIPIVG IVAGLAVLAV LAVLGAVVAV VMCRRKSSGG KGGSCSQAAS SNSAQGSDES LIACKA //